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B4DWG8

- B4DWG8_HUMAN

UniProt

B4DWG8 - B4DWG8_HUMAN

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Protein
Submitted name:

cDNA FLJ60923, highly similar to Phosphate-regulating neutral endopeptidase (EC3.4.24.-)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. organophosphate metabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ60923, highly similar to Phosphate-regulating neutral endopeptidase (EC3.4.24.-)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiB4DWG8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB4DWG8.
SMRiB4DWG8. Positions 4-652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG005554.
KOiK08636.

Family and domain databases

Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.

Sequencei

Sequence statusi: Complete.

B4DWG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSYGVYPWL RHNVDLKLKE LLEKSISRRR DTEAIQKAKI LYSSCMNEKA
60 70 80 90 100
IEKADAKPLL HILRHSPFRW PVLESNIGPE GVWSERKFSL LQTLATFRGQ
110 120 130 140 150
YSNSVFIRLY VSPDDKASNE HILKLDQATL SLAVREDYLD NSTEAKSYRD
160 170 180 190 200
ALYKFMVDTA VLLGANSSRA EHDMKSVLRL EIKIAEIMIP HENRTSEAMY
210 220 230 240 250
NKMNISELSA MIPQFDWLGY IKKVIDTRLY PHLKDISPSE NVVVRVPQYF
260 270 280 290 300
KDLFRILGSE RKKTIANYLV WRMVYSRIPN LSRRFQYRWL EFSRVIQGTT
310 320 330 340 350
TLLPQWDKCV NFIESALPYV VGKMFVDVYF QEDKKEMMEE LVEGVRWAFI
360 370 380 390 400
DMLEKENEWM DAGTKRKAKE KARAVLAKVG YPEFIMNDTH VNEDLKAIKF
410 420 430 440 450
SEADYFGNVL QTRKYLAQSD FFWLRKAVPK TEWFTNPTTV NAFYSASTNQ
460 470 480 490 500
IRFPAGELQK PFFWGTEYPR SLSYGAIGVI VGHEFTHGFD NNGRKYDKNG
510 520 530 540 550
NLDPWWSTES EEKFKEKTKC MINQYSNYYW KKAGLNVKGK RTLGENIADN
560 570 580 590 600
GGLREAFRAY RKWINDRRQG LEEPLLPGIT FTNNQLFFLS YAHVRCNSYR
610 620 630 640 650
PEAAREQVQI GAHSPPQFRV NGAISNFEEF QKAFNCPPNS TMNRGMDSCR

LW
Length:652
Mass (Da):76,100
Last modified:September 23, 2008 - v1
Checksum:i7369FB60ED0365AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK301528 mRNA. Translation: BAG63030.1.
RefSeqiNP_000435.3. NM_000444.5.
NP_001269683.1. NM_001282754.1.
UniGeneiHs.495834.

Genome annotation databases

GeneIDi5251.
KEGGihsa:5251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK301528 mRNA. Translation: BAG63030.1 .
RefSeqi NP_000435.3. NM_000444.5.
NP_001269683.1. NM_001282754.1.
UniGenei Hs.495834.

3D structure databases

ProteinModelPortali B4DWG8.
SMRi B4DWG8. Positions 4-652.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5251.
KEGGi hsa:5251.

Organism-specific databases

CTDi 5251.

Phylogenomic databases

HOVERGENi HBG005554.
KOi K08636.

Miscellaneous databases

ChiTaRSi PHEX. human.
GenomeRNAii 5251.
NextBioi 35475716.

Gene expression databases

ExpressionAtlasi B4DWG8. baseline and differential.

Family and domain databases

Gene3Di 3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view ]
PANTHERi PTHR11733. PTHR11733. 1 hit.
Pfami PF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view ]
PRINTSi PR00786. NEPRILYSIN.
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Synovial membrane tissueImported.

Entry informationi

Entry nameiB4DWG8_HUMAN
AccessioniPrimary (citable) accession number: B4DWG8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.