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B4DWG8 (B4DWG8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

cDNA FLJ60923, highly similar to Phosphate-regulating neutral endopeptidase (EC3.4.24.-) EMBL BAG63030.1
Gene names
Name:PHEX Ensembl ENSP00000439418
OrganismHomo sapiens (Human) [Reference proteome] EMBL BAG63030.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length652 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Sequences

Sequence LengthMass (Da)Tools
B4DWG8 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 7369FB60ED0365AF

FASTA65276,100
        10         20         30         40         50         60 
MPSYGVYPWL RHNVDLKLKE LLEKSISRRR DTEAIQKAKI LYSSCMNEKA IEKADAKPLL 

        70         80         90        100        110        120 
HILRHSPFRW PVLESNIGPE GVWSERKFSL LQTLATFRGQ YSNSVFIRLY VSPDDKASNE 

       130        140        150        160        170        180 
HILKLDQATL SLAVREDYLD NSTEAKSYRD ALYKFMVDTA VLLGANSSRA EHDMKSVLRL 

       190        200        210        220        230        240 
EIKIAEIMIP HENRTSEAMY NKMNISELSA MIPQFDWLGY IKKVIDTRLY PHLKDISPSE 

       250        260        270        280        290        300 
NVVVRVPQYF KDLFRILGSE RKKTIANYLV WRMVYSRIPN LSRRFQYRWL EFSRVIQGTT 

       310        320        330        340        350        360 
TLLPQWDKCV NFIESALPYV VGKMFVDVYF QEDKKEMMEE LVEGVRWAFI DMLEKENEWM 

       370        380        390        400        410        420 
DAGTKRKAKE KARAVLAKVG YPEFIMNDTH VNEDLKAIKF SEADYFGNVL QTRKYLAQSD 

       430        440        450        460        470        480 
FFWLRKAVPK TEWFTNPTTV NAFYSASTNQ IRFPAGELQK PFFWGTEYPR SLSYGAIGVI 

       490        500        510        520        530        540 
VGHEFTHGFD NNGRKYDKNG NLDPWWSTES EEKFKEKTKC MINQYSNYYW KKAGLNVKGK 

       550        560        570        580        590        600 
RTLGENIADN GGLREAFRAY RKWINDRRQG LEEPLLPGIT FTNNQLFFLS YAHVRCNSYR 

       610        620        630        640        650 
PEAAREQVQI GAHSPPQFRV NGAISNFEEF QKAFNCPPNS TMNRGMDSCR LW 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"NEDO human cDNA sequencing project focused on splicing variants."
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. expand/collapse author list , Sugano S., Nomura N., Isogai T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Synovial membrane tissue EMBL BAG63030.1.
[3]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y10196 Genomic DNA. No translation available.
AK301528 mRNA. Translation: BAG63030.1.
RefSeqNP_000435.3. NM_000444.5.
NP_001269683.1. NM_001282754.1.
UniGeneHs.495834.

3D structure databases

ProteinModelPortalB4DWG8.
SMRB4DWG8. Positions 4-652.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000535894; ENSP00000439418; ENSG00000102174.
GeneID5251.
KEGGhsa:5251.

Organism-specific databases

CTD5251.
HGNCHGNC:8918. PHEX.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG005554.
KOK08636.

Family and domain databases

Gene3D3.40.390.10. 2 hits.
InterProIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERPTHR11733. PTHR11733. 1 hit.
PfamPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSPR00786. NEPRILYSIN.
ProtoNetSearch...

Other

ChiTaRSPHEX. human.
NextBio35475716.

Entry information

Entry nameB4DWG8_HUMAN
AccessionPrimary (citable) accession number: B4DWG8
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.