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Protein
Submitted name:

Caspase-1

Gene

CASP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase-1Imported
Submitted name:
cDNA FLJ59442, highly similar to Caspase-1 (EC 3.4.22.36)Imported
Gene namesi
Name:CASP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1499. CASP1.

PTM / Processingi

Proteomic databases

EPDiB4DVD8.
PaxDbiB4DVD8.

Expressioni

Gene expression databases

ExpressionAtlasiB4DVD8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000410076.

Chemistry

BindingDBiB4DVD8.

Structurei

3D structure databases

ProteinModelPortaliB4DVD8.
SMRiB4DVD8. Positions 1-50, 86-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5252CARDInterPro annotationAdd
BLAST
Domaini122 – 250129CASPASE_P20InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.SAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOVERGENiHBG076981.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A_HD.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DVD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVKRENAT VMDKTRALID SVIPKGAQAC QICITYICEE DSYLAGTLGL
60 70 80 90 100
SADQTSGNYL NMQDSQGVLS SFPAPQAVQD NPAMPTSSGS EGNVKLCSLE
110 120 130 140 150
EAQRIWKQKS AEIYPIMDKS SRTRLALIIC NEEFDSIPRR TGAEVDITGM
160 170 180 190 200
TMLLQNLGYS VDVKKNLTAS DMTTELEAFA HRPEHKTSDS TFLVFMSHGI
210 220 230 240 250
REGICGKKHS EQVPDILQLN AIFNMLNTKN CPSLKDKPKV IIIQACRGDS
260 270 280 290 300
PGVVWFKDSV GVSGNLSLPT TEEFEDDAIK KAHIEKDFIA FCSSTPGKSQ

S
Length:301
Mass (Da):33,010
Last modified:September 23, 2008 - v1
Checksum:i4876CD6462F08AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001153 Genomic DNA. No translation available.
KF455483 Genomic DNA. No translation available.
AK301037 mRNA. Translation: BAG62650.1.
UniGeneiHs.2490.

Genome annotation databases

EnsembliENST00000528974; ENSP00000434259; ENSG00000137752.
UCSCiuc010rvk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001153 Genomic DNA. No translation available.
KF455483 Genomic DNA. No translation available.
AK301037 mRNA. Translation: BAG62650.1.
UniGeneiHs.2490.

3D structure databases

ProteinModelPortaliB4DVD8.
SMRiB4DVD8. Positions 1-50, 86-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000410076.

Chemistry

BindingDBiB4DVD8.

Proteomic databases

EPDiB4DVD8.
PaxDbiB4DVD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528974; ENSP00000434259; ENSG00000137752.
UCSCiuc010rvk.4. human.

Organism-specific databases

HGNCiHGNC:1499. CASP1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOVERGENiHBG076981.

Miscellaneous databases

ChiTaRSiCASP1. human.
NextBioi35475431.

Gene expression databases

ExpressionAtlasiB4DVD8. baseline and differential.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A_HD.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB4DVD8_HUMAN
AccessioniPrimary (citable) accession number: B4DVD8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 11, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.