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Protein
Submitted name:

Caspase-1

Gene

CASP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase-1Imported
Submitted name:
cDNA FLJ59442, highly similar to Caspase-1 (EC 3.4.22.36)Imported
Gene namesi
Name:CASP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137752.22
HGNCiHGNC:1499 CASP1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137752

PTM / Processingi

Proteomic databases

MaxQBiB4DVD8
PeptideAtlasiB4DVD8

Expressioni

Gene expression databases

BgeeiENSG00000137752

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 52CARDInterPro annotationAdd BLAST52
Domaini122 – 250CASPASE_P20InterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the peptidase C14A family.SAAS annotation

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00910000144131
HOVERGENiHBG076981

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequencei

Sequence statusi: Complete.

B4DVD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVKRENAT VMDKTRALID SVIPKGAQAC QICITYICEE DSYLAGTLGL
60 70 80 90 100
SADQTSGNYL NMQDSQGVLS SFPAPQAVQD NPAMPTSSGS EGNVKLCSLE
110 120 130 140 150
EAQRIWKQKS AEIYPIMDKS SRTRLALIIC NEEFDSIPRR TGAEVDITGM
160 170 180 190 200
TMLLQNLGYS VDVKKNLTAS DMTTELEAFA HRPEHKTSDS TFLVFMSHGI
210 220 230 240 250
REGICGKKHS EQVPDILQLN AIFNMLNTKN CPSLKDKPKV IIIQACRGDS
260 270 280 290 300
PGVVWFKDSV GVSGNLSLPT TEEFEDDAIK KAHIEKDFIA FCSSTPGKSQ

S
Length:301
Mass (Da):33,010
Last modified:September 23, 2008 - v1
Checksum:i4876CD6462F08AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001153 Genomic DNA No translation available.
KF455483 Genomic DNA No translation available.
AK301037 mRNA Translation: BAG62650.1
UniGeneiHs.2490

Genome annotation databases

EnsembliENST00000528974; ENSP00000434259; ENSG00000137752
UCSCiuc010rvk.4 human

Entry informationi

Entry nameiB4DVD8_HUMAN
AccessioniPrimary (citable) accession number: B4DVD8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health