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Protein

GTP-binding nuclear protein Ran

Gene

RAN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transportUniRule annotation, Transport
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein RanUniRule annotation
Gene namesi
Name:RANImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9846. RAN.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132341.

PTM / Processingi

Proteomic databases

MaxQBiB4DV51.

Expressioni

Gene expression databases

BgeeiENSG00000132341.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376176.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
HOVERGENiHBG097113.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51418. RAN. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DV51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDVTSRVTY KNVPNWHRDL VRVCENIPIV LCGNKVDIKD RKVKAKSIVF
60 70 80 90 100
HRKKNLQYYD ISAKSNYNFE KPFLWLARKL IGDPNLEFVA MPALAPPEVV
110 120
MDPALAAQYE HDLEVAQTTA LPDEDDDL
Length:128
Mass (Da):14,731
Last modified:September 23, 2008 - v1
Checksum:i6F87C0AC20E185EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073912 Genomic DNA. No translation available.
AK300934 mRNA. Translation: BAG62563.1.
AK316193 mRNA. Translation: BAH14564.1.
RefSeqiNP_001287725.1. NM_001300796.1.
NP_001287726.1. NM_001300797.1.
UniGeneiHs.10842.

Genome annotation databases

EnsembliENST00000541630; ENSP00000441210; ENSG00000132341.
GeneIDi5901.
UCSCiuc010tbl.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073912 Genomic DNA. No translation available.
AK300934 mRNA. Translation: BAG62563.1.
AK316193 mRNA. Translation: BAH14564.1.
RefSeqiNP_001287725.1. NM_001300796.1.
NP_001287726.1. NM_001300797.1.
UniGeneiHs.10842.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376176.

Proteomic databases

MaxQBiB4DV51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541630; ENSP00000441210; ENSG00000132341.
GeneIDi5901.
UCSCiuc010tbl.3. human.

Organism-specific databases

CTDi5901.
HGNCiHGNC:9846. RAN.
OpenTargetsiENSG00000132341.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
HOVERGENiHBG097113.

Miscellaneous databases

ChiTaRSiRAN. human.
GenomeRNAii5901.

Gene expression databases

BgeeiENSG00000132341.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51418. RAN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4DV51_HUMAN
AccessioniPrimary (citable) accession number: B4DV51
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.