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Protein
Submitted name:

Hydroxyacid-oxoacid transhydrogenase, mitochondrial

Gene

ADHFE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metal ion binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Hydroxyacid-oxoacid transhydrogenase, mitochondrialImported
Submitted name:
cDNA FLJ53664, highly similar to Rattus norvegicus alcohol dehydrogenase, iron containing, 1 (Adhfe1), mRNAImported
Gene namesi
Name:ADHFE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:16354. ADHFE1.

Expressioni

Gene expression databases

BgeeiB4DV11.
ExpressionAtlasiB4DV11. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB4DV11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000003849.
HOGENOMiHOG000069907.
HOVERGENiHBG103454.

Family and domain databases

InterProiIPR001670. ADH_Fe.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DV11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAARARVA YLLRQLQRAA CQCPTHSHTY SQAPGLSPSG KTTDYAFEMA
60 70 80 90 100
VSNIRYGAAV TKEVGMDLKN MGAKNVCLMT DKNLSKLPPV QVAMDSLVKN
110 120
GIPFTVYDNV RVEPTDSSAN YLRNRE
Length:126
Mass (Da):13,770
Last modified:September 23, 2008 - v1
Checksum:i9AAC8D7F89449762
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009879 Genomic DNA. No translation available.
KF458771 Genomic DNA. No translation available.
AK300881 mRNA. Translation: BAG62523.1.
UniGeneiHs.720023.

Genome annotation databases

EnsembliENST00000396621; ENSP00000379864; ENSG00000147576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009879 Genomic DNA. No translation available.
KF458771 Genomic DNA. No translation available.
AK300881 mRNA. Translation: BAG62523.1.
UniGeneiHs.720023.

3D structure databases

ProteinModelPortaliB4DV11.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396621; ENSP00000379864; ENSG00000147576.

Organism-specific databases

HGNCiHGNC:16354. ADHFE1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000003849.
HOGENOMiHOG000069907.
HOVERGENiHBG103454.

Miscellaneous databases

NextBioi35475326.

Gene expression databases

BgeeiB4DV11.
ExpressionAtlasiB4DV11. baseline and differential.

Family and domain databases

InterProiIPR001670. ADH_Fe.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Small intestineImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB4DV11_HUMAN
AccessioniPrimary (citable) accession number: B4DV11
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 29, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.