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Protein

Protein arginine N-methyltransferase 5

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei218S-adenosyl-L-methionineUniRule annotation1
Sitei221Critical for specifying symmetric addition of methyl groupsUniRule annotation1
Binding sitei286S-adenosyl-L-methionineUniRule annotation1
Active sitei329Proton donor/acceptorUniRule annotation1
Active sitei338Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 5UniRule annotation (EC:2.1.1.-UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

EPDiB4DV00
MaxQBiB4DV00
PeptideAtlasiB4DV00
PRIDEiB4DV00

Structurei

3D structure databases

ProteinModelPortaliB4DV00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 184PRMT5_TIMInterPro annotationAdd BLAST183
Domaini191 – 358PRMT5InterPro annotationAdd BLAST168
Domaini361 – 529PRMT5_CInterPro annotationAdd BLAST169

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 228S-adenosyl-L-methionine bindingUniRule annotation2
Regioni313 – 314S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0822 Eukaryota
ENOG410XNZM LUCA
HOVERGENiHBG057083

Family and domain databases

InterProiView protein in InterPro
IPR025799 Arg_MeTrfase
IPR007857 Arg_MeTrfase_PRMT5
IPR035075 PRMT5
IPR035248 PRMT5_C
IPR035247 PRMT5_TIM
IPR029063 SAM-dependent_MTases
PANTHERiPTHR10738 PTHR10738, 1 hit
PfamiView protein in Pfam
PF05185 PRMT5, 1 hit
PF17286 PRMT5_C, 1 hit
PF17285 PRMT5_TIM, 1 hit
PIRSFiPIRSF015894 Skb1_MeTrfase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51678 SAM_MT_PRMT, 1 hit

Sequencei

Sequence statusi: Complete.

B4DV00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQELNFGAY LGLPAFLLPL NQEDNTNLAR VLTNHIHTGH HSSMFWMRVP
60 70 80 90 100
LVAPEDLRDD IIENAPTTHT EEYSGEEKTW MWWHNFRTLC DYSKRIAVAL
110 120 130 140 150
EIGADLPSNH VIDRWLGEPI KAAILPTSIF LTNKKGFPVL SKMHQRLIFR
160 170 180 190 200
LLKLEVQFII TGTNHHSEKE FCSYLQYLEY LSQNRPPPNA YELFAKGYED
210 220 230 240 250
YLQSPLQPLM DNLESQTYEV FEKDPIKYSQ YQQAIYKCLL DRVPEEEKDT
260 270 280 290 300
NVQVLMVLGA GRGPLVNASL RAAKQADRRI KLYAVEKNPN AVVTLENWQF
310 320 330 340 350
EEWGSQVTVV SSDMREWVAP EKADIIVSEL LGSFADNELS PECLDGAQHF
360 370 380 390 400
LKDDGVSIPG EYTSFLAPIS SSKLYNEVRA CREKDRDPEA QFEMPYVVRL
410 420 430 440 450
HNFHQLSAPQ PCFTFSHPNR DPMIDNNRYC TLEFPVEVNT VLHGFAGYFE
460 470 480 490 500
TVLYQDITLS IRPETHSPGM FSWFPILFPI KQPITVREGQ TICVRFWRCS
510 520 530
NSKKVWYEWA VTAPVCSAIH NPTGRSYTIG L
Length:531
Mass (Da):61,108
Last modified:September 23, 2008 - v1
Checksum:i223B66796E0FD47A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300863 mRNA Translation: BAG62512.1
RefSeqiNP_001269883.1, NM_001282954.1
XP_016876416.1, XM_017020927.1
UniGeneiHs.367854

Genome annotation databases

GeneIDi10419

Similar proteinsi

Entry informationi

Entry nameiB4DV00_HUMAN
AccessioniPrimary (citable) accession number: B4DV00
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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