ID   B4DUV4_HUMAN            Unreviewed;       177 AA.
AC   B4DUV4;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   RecName: Full=GDP-fucose protein O-fucosyltransferase 1 {ECO:0000256|ARBA:ARBA00021745};
DE            EC=2.4.1.221 {ECO:0000256|ARBA:ARBA00012196};
DE   AltName: Full=Peptide-O-fucosyltransferase 1 {ECO:0000256|ARBA:ARBA00033080};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG62466.1};
RN   [1] {ECO:0000313|EMBL:BAG62466.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)-
CC         L-seryl-[protein] + GDP + H(+); Xref=Rhea:RHEA:63644, Rhea:RHEA-
CC         COMP:9863, Rhea:RHEA-COMP:17914, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:189632; EC=2.4.1.221;
CC         Evidence={ECO:0000256|ARBA:ARBA00033615};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63645;
CC         Evidence={ECO:0000256|ARBA:ARBA00033615};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-beta-L-fucose + L-threonyl-[protein] = 3-O-(alpha-L-
CC         fucosyl)-L-threonyl-[protein] + GDP + H(+); Xref=Rhea:RHEA:70491,
CC         Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:17915, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30013, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:189631; EC=2.4.1.221;
CC         Evidence={ECO:0000256|ARBA:ARBA00033628};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70492;
CC         Evidence={ECO:0000256|ARBA:ARBA00033628};
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 65 family.
CC       {ECO:0000256|ARBA:ARBA00010626}.
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DR   EMBL; AK300810; BAG62466.1; -; mRNA.
DR   AlphaFoldDB; B4DUV4; -.
DR   MaxQB; B4DUV4; -.
DR   PeptideAtlas; B4DUV4; -.
DR   ProteomicsDB; 5221; -.
DR   UniPathway; UPA00378; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0046922; F:peptide-O-fucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.50.11350; -; 1.
DR   InterPro; IPR019378; GDP-Fuc_O-FucTrfase.
DR   InterPro; IPR039922; POFUT1.
DR   PANTHER; PTHR21420; GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1; 1.
DR   PANTHER; PTHR21420:SF3; GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1; 1.
DR   Pfam; PF10250; O-FucT; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Fucose metabolism {ECO:0000256|ARBA:ARBA00023253};
KW   Glycosyltransferase {ECO:0000313|EMBL:BAG62466.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAG62466.1}.
SQ   SEQUENCE   177 AA;  19811 MW;  84F1D479DD9A5348 CRC64;
     MVWSDEMVKT GEAQIHAHLV RPYVGIHLRI GSDWKNACAM LKDGTAGSHF MASPQCVGYS
     RSTAAPLTMT MCLPDLKEIQ RAVKLWVRSL DAQSVYVATD SESYVPELQQ LFKGKVKVVS
     LKPEVAQVDL YILGQADHFI GNCVSSFTAF VKRERDLQGR PSSFFGMDRP PKLRDEF
//