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Protein

Calponin

Gene

CNN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation, Calmodulin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
CalponinUniRule annotation
Gene namesi
Name:CNN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:2156. CNN2.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064666.

PTM / Processingi

Proteomic databases

MaxQBiB4DUT8.

Expressioni

Gene expression databases

BgeeiENSG00000064666.
ExpressionAtlasiB4DUT8. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiB4DUT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 131Actin-bindingInterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the calponin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
OMAiIPDYQDE.
OrthoDBiEOG091G0LY2.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR029974. CNN2.
IPR003096. SM22_calponin.
PANTHERiPTHR18959:SF71. PTHR18959:SF71. 1 hit.
PfamiView protein in Pfam
PF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS01052. CALPONIN_1. 2 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DUT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF
60 70 80 90 100
QKGLKDGTIL CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM
110 120 130 140 150
NPVDLFEAND LFESGNMTQV QVSLLALAGK GLDLGSLAAL CWYSRPLSLT
160 170 180 190 200
QAKTKGLQSG VDIGVKYSEK QERNFDDATM KAGQCVIGLQ MGTNKCASQS
210 220 230 240 250
GMTAYGTRRH LYDPKNHILP PMDHSTISLQ MGTNKCASQV GMTAPGTRRH
260 270 280 290 300
IYDTKLGTDK CDNSSMSLQM GYTQGANQSG QVFGLGRQIY DPKYCPQGTV
310 320 330
ADGAPSGTGD CPDPGEVPEY PPYYQEEAGY
Length:330
Mass (Da):35,944
Last modified:September 23, 2008 - v1
Checksum:iCB7E8A74CA422FD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. No translation available.
AC011558 Genomic DNA. No translation available.
AK300788 mRNA. Translation: BAG62450.1.
RefSeqiNP_001290430.1. NM_001303501.1.
UniGeneiHs.651512.

Genome annotation databases

EnsembliENST00000562958; ENSP00000456436; ENSG00000064666.
GeneIDi1265.
UCSCiuc010xgc.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB4DUT8_HUMAN
AccessioniPrimary (citable) accession number: B4DUT8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 5, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported