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B4DUM2

- B4DUM2_HUMAN

UniProt

B4DUM2 - B4DUM2_HUMAN

Protein
Submitted name:

cDNA FLJ53891, highly similar to Adenylosuccinate lyase (EC 4.3.2.2)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: Ensembl
    2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: Ensembl

    GO - Biological processi

    1. aerobic respiration Source: Ensembl
    2. AMP biosynthetic process Source: Ensembl
    3. protein tetramerization Source: Ensembl
    4. response to hypoxia Source: Ensembl
    5. response to muscle activity Source: Ensembl
    6. response to nutrient Source: Ensembl
    7. response to starvation Source: Ensembl

    Keywords - Molecular functioni

    LyaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA FLJ53891, highly similar to Adenylosuccinate lyase (EC 4.3.2.2)Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrion Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiB4DUM2.

    Expressioni

    Gene expression databases

    ArrayExpressiB4DUM2.
    BgeeiB4DUM2.

    Structurei

    3D structure databases

    ProteinModelPortaliB4DUM2.
    SMRiB4DUM2. Positions 1-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR019468. AdenyloSucc_lyase_C.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    [Graphical view]
    PANTHERiPTHR11444. PTHR11444. 1 hit.
    PfamiPF10397. ADSL_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view]
    PRINTSiPR00149. FUMRATELYASE.
    SMARTiSM00998. ADSL_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48557. SSF48557. 1 hit.
    PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4DUM2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLQNLKRVR DDLRFRGVKG TTGTQASFLQ LFEGDDHKVE QLDKMVTEKA    50
    GFKRAFIITG QTYTRKVDIE VLSVLASLGA SVHKICTDIR LLANLKEMEE 100
    PFEKQQIGSS AMPYKRNPMR SERCCSLARH LMTLVMDPLQ TASVQWFERT 150
    LDDSANRRIC LAEAFLTADT ILNTLQNISE GLVVYPKVIE RRIRQELPFM 200
    ATENIIMAMV KAGGSRQDCH EKIRVLSQQA ASVVKQEGGD NDLIERIQVD 250
    AYFSPIHSQL DHLLDPSSFT GRASQQVQRF LEEEVYPLLK PYESVMKVKA 300
    ELCL 304
    Length:304
    Mass (Da):34,555
    Last modified:September 23, 2008 - v1
    Checksum:iEB0C042A7A79A624
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300705 mRNA. Translation: BAG62384.1.
    UniGeneiHs.75527.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300705 mRNA. Translation: BAG62384.1 .
    UniGenei Hs.75527.

    3D structure databases

    ProteinModelPortali B4DUM2.
    SMRi B4DUM2. Positions 1-294.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B4DUM2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35475227.

    Gene expression databases

    ArrayExpressi B4DUM2.
    Bgeei B4DUM2.

    Family and domain databases

    InterProi IPR019468. AdenyloSucc_lyase_C.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    [Graphical view ]
    PANTHERi PTHR11444. PTHR11444. 1 hit.
    Pfami PF10397. ADSL_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00149. FUMRATELYASE.
    SMARTi SM00998. ADSL_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48557. SSF48557. 1 hit.
    PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Skeletal muscleImported.

    Entry informationi

    Entry nameiB4DUM2_HUMAN
    AccessioniPrimary (citable) accession number: B4DUM2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.