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Protein

Zinc finger protein 879

Gene

ZNF879

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 56223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 879
Gene namesi
Name:ZNF879
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:37273. ZNF879.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165660603.

Polymorphism and mutation databases

BioMutaiZNF879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Zinc finger protein 879PRO_0000393967Add
BLAST

Proteomic databases

EPDiB4DU55.
PaxDbiB4DU55.
PRIDEiB4DU55.

PTM databases

iPTMnetiB4DU55.
PhosphoSiteiB4DU55.

Expressioni

Gene expression databases

BgeeiB4DU55.
ExpressionAtlasiB4DU55. baseline and differential.
GenevisibleiB4DU55. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000414887.

Structurei

3D structure databases

ProteinModelPortaliB4DU55.
SMRiB4DU55. Positions 201-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 56223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB4DU55.
KOiK09228.
OMAiQQYSVLF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiB4DU55.
TreeFamiTF350823.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DU55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRLLPAHV QESVTFRDVA VFFSQDEWLH LDSAQRALYR EVMLENYSIL
60 70 80 90 100
VSLGILFSKP KVISQLEQGE DPWMVESGVP QGAHLGWESL FGTIVSKEEN
110 120 130 140 150
QEVMKKLIID GTFDFKLEKT YINEDKLEKQ QGKKNRLFSK VLVTIKKVYM
160 170 180 190 200
KERSFKGVEF GKNLGLKSSL IRKPRIVSRG RRPRSQQYSV LFKQLGVNTV
210 220 230 240 250
RKCYKCNICG KIFLHSSSLS KHQRIHTGEK LYKCKECRKA FSQSSSLTQH
260 270 280 290 300
LRVHTGEKPY ICSECGKAFS FTTSLIGHQR MHTGERPYKC KECGKTFKGS
310 320 330 340 350
SSLNNHQRIH TGEKPYKCNE CGRAFSQCSS LIQHHRIHTG EKPYECTQCG
360 370 380 390 400
KAFTSISRLS RHHRIHTGEK PFHCNECGKV FSYHSALIIH QRIHTGEKPY
410 420 430 440 450
ACKECGKAFS QSSALIQHQR IHTGEKPYKC NECGKAFSWI SRLNIHHRIH
460 470 480 490 500
TGEKPYNCKE CGKAFSSHSG VNTHRKIHTG EKPYKCNDCE KAFNQSSALI
510 520 530 540 550
QHQRIHTGEK PYNCKVCGKA FRQSSSLMTH MRIHTGEKPY KCKECGKAFS
560
QSSSLTNHQR THN
Length:563
Mass (Da):64,577
Last modified:May 18, 2010 - v2
Checksum:i0BF85BAA4B4D5CF4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381R → G in BAG62217 (PubMed:14702039).Curated
Sequence conflicti267 – 2671K → N in BAG62217 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300504 mRNA. Translation: BAG62217.1.
AC104117 Genomic DNA. No translation available.
CCDSiCCDS47352.1.
RefSeqiNP_001129588.1. NM_001136116.1.
XP_005265965.1. XM_005265908.2.
XP_011532852.1. XM_011534550.1.
XP_011532853.1. XM_011534551.1.
UniGeneiHs.445740.

Genome annotation databases

EnsembliENST00000444149; ENSP00000414887; ENSG00000234284.
GeneIDi345462.
KEGGihsa:345462.
UCSCiuc003mjt.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300504 mRNA. Translation: BAG62217.1.
AC104117 Genomic DNA. No translation available.
CCDSiCCDS47352.1.
RefSeqiNP_001129588.1. NM_001136116.1.
XP_005265965.1. XM_005265908.2.
XP_011532852.1. XM_011534550.1.
XP_011532853.1. XM_011534551.1.
UniGeneiHs.445740.

3D structure databases

ProteinModelPortaliB4DU55.
SMRiB4DU55. Positions 201-562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000414887.

PTM databases

iPTMnetiB4DU55.
PhosphoSiteiB4DU55.

Polymorphism and mutation databases

BioMutaiZNF879.

Proteomic databases

EPDiB4DU55.
PaxDbiB4DU55.
PRIDEiB4DU55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000444149; ENSP00000414887; ENSG00000234284.
GeneIDi345462.
KEGGihsa:345462.
UCSCiuc003mjt.5. human.

Organism-specific databases

CTDi345462.
GeneCardsiZNF879.
HGNCiHGNC:37273. ZNF879.
neXtProtiNX_B4DU55.
PharmGKBiPA165660603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB4DU55.
KOiK09228.
OMAiQQYSVLF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiB4DU55.
TreeFamiTF350823.

Miscellaneous databases

GenomeRNAii345462.
NextBioi98856.
PROiB4DU55.

Gene expression databases

BgeeiB4DU55.
ExpressionAtlasiB4DU55. baseline and differential.
GenevisibleiB4DU55. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN879_HUMAN
AccessioniPrimary (citable) accession number: B4DU55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.