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Protein
Submitted name:

cDNA FLJ53921, highly similar to Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ53921, highly similar to Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei716 – 74126HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiB4DTW8.
PRIDEiB4DTW8.

Expressioni

Gene expression databases

GenevisibleiB4DTW8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361554.

Structurei

3D structure databases

ProteinModelPortaliB4DTW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini180 – 21132EGF-likeInterPro annotationAdd
BLAST
Domaini266 – 30035EGF-likeInterPro annotationAdd
BLAST
Domaini401 – 500100Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini503 – 59795Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini601 – 69494Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini794 – 1073280Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG007316.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF12661. hEGF. 1 hit.
PF00047. ig. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00181. EGF. 3 hits.
SM00060. FN3. 3 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 2 hits.
PS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DTW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWAGAGRGSD AWGPPLLLEK DDRIVRTPPG PPLRLARNGS HQVTLRGFSK
60 70 80 90 100
PSDLVGVFSC VGGAGARRTR VIYVHNSPGA HLLPDKVTHT VNKGDTAVLS
110 120 130 140 150
ARVHKEKQTD VIWKSNGSYF YTLDWHEAQD GRFLLQLPNV QPPSSGIYSA
160 170 180 190 200
TYLEASPLGS AFFRLIVRGC GAGRWGPGCT KECPGCLHGG VCHDHDGECV
210 220 230 240 250
CPPGFTGTRC EQACREGRFG QSCQEQCPGI SGCRGLTFCL PDPYGCSCGS
260 270 280 290 300
GWRGSQCQEA CAPGHFGADC RLQCQCQNGG TCDRFSGCVC PSGWHGVHCE
310 320 330 340 350
KSDRIPQILN MASELEFNLE TMPRINCAAA GNPFPVRGSI ELRKPDGTVL
360 370 380 390 400
LSTKAIVEPE KTTAEFEVPR LVLADSGFWE CRVSTSGGQD SRRFKVNVKV
410 420 430 440 450
PPVPLAAPRL LTKQSRQLVV SPLVSFSGDG PISTVRLHYR PQDSTMDWST
460 470 480 490 500
IVVDPSENVT LMNLRPKTGY SVRVQLSRPG EGGEGAWGPP TLMTTDCPEP
510 520 530 540 550
LLQPWLEGWH VEGTDRLRVS WSLPLVPGPL VGDGFLLRLW DGTRGQERRE
560 570 580 590 600
NVSSPQARTA LLTGLTPGTH YQLDVQLYHC TLLGPASPPA HVLLPPSGPP
610 620 630 640 650
APRHLHAQAL SDSEIQLTWK HPEALPGPIS KYVVEVQVAG GAGDPLWIDV
660 670 680 690 700
DRPEETSTII RGLNASTRYL FRMRASIQGL GDWSNTVEES TLGNGLQAEG
710 720 730 740 750
PVQESRAAEE GLDQQLILAV VGSVSATCLT ILAALLTLVC IRRSCLHRRR
760 770 780 790 800
TFTYQSGSGE ETILQFSSGT LTLTRRPKLQ PEPLSYPVLE WEDITFEDLI
810 820 830 840 850
GEGNFGQVIR AMIKKDGLKM NAAIKMLKEY ASENDHRDFA GELEVLCKLG
860 870 880 890 900
HHPNIINLLG ACKNRGYLYI AIEYAPYGNL LDFLRKSRVL ETDPAFAREH
910 920 930 940 950
GTASTLSSRQ LLRFASDAAN GMQYLSEKQF IHRDLAARNV LVGENLASKI
960 970 980 990 1000
ADFGLSRGEE VYVKKTMGRL PVRWMAIESL NYSVYTTKSD VWSFGVLLWE
1010 1020 1030 1040 1050
IVSLGGTPYC GMTCAELYEK LPQGYRMEQP RNCDDEVYEL MRQCWRDRPY
1060 1070 1080 1090
ERPPFAQIAL QLGRMLEARK AYVNMSLFEN FTYAGIDATA EEA
Length:1,093
Mass (Da):120,186
Last modified:September 23, 2008 - v1
Checksum:i73614F6A97FD3E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300399 mRNA. Translation: BAG62130.1.
RefSeqiNP_001240286.1. NM_001253357.1.
UniGeneiHs.78824.

Genome annotation databases

GeneIDi7075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300399 mRNA. Translation: BAG62130.1.
RefSeqiNP_001240286.1. NM_001253357.1.
UniGeneiHs.78824.

3D structure databases

ProteinModelPortaliB4DTW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361554.

Proteomic databases

PaxDbiB4DTW8.
PRIDEiB4DTW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7075.

Organism-specific databases

CTDi7075.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG007316.

Miscellaneous databases

GenomeRNAii7075.

Gene expression databases

GenevisibleiB4DTW8. HS.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF12661. hEGF. 1 hit.
PF00047. ig. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00181. EGF. 3 hits.
SM00060. FN3. 3 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 2 hits.
PS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.

Entry informationi

Entry nameiB4DTW8_HUMAN
AccessioniPrimary (citable) accession number: B4DTW8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.