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Protein

Receptor protein-tyrosine kinase

Gene

ERBB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:ERBB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:3430. ERBB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei378 – 39922HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 979957Receptor protein-tyrosine kinaseSequence analysisPRO_5007640563Add
BLAST

Proteomic databases

PeptideAtlasiB4DTR1.

Expressioni

Gene expression databases

BgeeiENSG00000141736.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000269571.

Structurei

3D structure databases

SMRiB4DTR1. Positions 26-733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini444 – 711268Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000230982.
HOVERGENiHBG000490.

Family and domain databases

Gene3Di3.80.20.20. 1 hit.
InterProiIPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF14843. GF_recep_IV. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DTR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELAALCRWG LLLALLPPGA ASTQDNYLST DVGSCTLVCP LHNQEVTAED
60 70 80 90 100
GTQRCEKCSK PCARVCYGLG MEHLREVRAV TSANIQEFAG CKKIFGSLAF
110 120 130 140 150
LPESFDGDPA SNTAPLQPEQ LQVFETLEEI TGYLYISAWP DSLPDLSVFQ
160 170 180 190 200
NLQVIRGRIL HNGAYSLTLQ GLGISWLGLR SLRELGSGLA LIHHNTHLCF
210 220 230 240 250
VHTVPWDQLF RNPHQALLHT ANRPEDECVG EGLACHQLCA RGHCWGPGPT
260 270 280 290 300
QCVNCSQFLR GQECVEECRV LQGLPREYVN ARHCLPCHPE CQPQNGSVTC
310 320 330 340 350
FGPEADQCVA CAHYKDPPFC VARCPSGVKP DLSYMPIWKF PDEEGACQPC
360 370 380 390 400
PINCTHSCVD LDDKGCPAEQ RASPLTSIIS AVVGILLVVV LGVVFGILIK
410 420 430 440 450
RRQQKIRKYT MRRLLQETEL VEPLTPSGAM PNQAQMRILK ETELRKVKVL
460 470 480 490 500
GSGAFGTVYK GIWIPDGENV KIPVAIKVLR ENTSPKANKE ILDEAYVMAG
510 520 530 540 550
VGSPYVSRLL GICLTSTVQL VTQLMPYGCL LDHVRENRGR LGSQDLLNWC
560 570 580 590 600
MQIAKGMSYL EDVRLVHRDL AARNVLVKSP NHVKITDFGL ARLLDIDETE
610 620 630 640 650
YHADGGKVPI KWMALESILR RRFTHQSDVW SYGVTVWELM TFGAKPYDGI
660 670 680 690 700
PAREIPDLLE KGERLPQPPI CTIDVYMIMV KCWMIDSECR PRFRELVSEF
710 720 730 740 750
SRMARDPQRF VVIQNEDLGP ASPLDSTFYR SLLEDDDMGD LVDAEEYLVP
760 770 780 790 800
QQGFFCPDPA PGAGGMVHHR HRSSSTRSGG GDLTLGLEPS EEEAPRSPLA
810 820 830 840 850
PSEGAGSDVF DGDLGMGAAK GLQSLPTHDP SPLQRYSEDP TVPLPSETDG
860 870 880 890 900
YVAPLTCSPQ PEYVNQPDVR PQPPSPREGP LPAARPAGAT LERPKTLSPG
910 920 930 940 950
KNGVVKDVFA FGGAVENPEY LTPQGGAAPQ PHPPPAFSPA FDNLYYWDQD
960 970
PPERGAPPST FKGTPTAENP EYLGLDVPV
Length:979
Mass (Da):107,571
Last modified:September 23, 2008 - v1
Checksum:iF0015E7394171A14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079199 Genomic DNA. No translation available.
AC087491 Genomic DNA. No translation available.
AK300321 mRNA. Translation: BAG62073.1.
UniGeneiHs.446352.

Genome annotation databases

EnsembliENST00000445658; ENSP00000404047; ENSG00000141736.
UCSCiuc010wek.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079199 Genomic DNA. No translation available.
AC087491 Genomic DNA. No translation available.
AK300321 mRNA. Translation: BAG62073.1.
UniGeneiHs.446352.

3D structure databases

SMRiB4DTR1. Positions 26-733.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269571.

Proteomic databases

PeptideAtlasiB4DTR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445658; ENSP00000404047; ENSG00000141736.
UCSCiuc010wek.3. human.

Organism-specific databases

HGNCiHGNC:3430. ERBB2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000230982.
HOVERGENiHBG000490.

Miscellaneous databases

ChiTaRSiERBB2. human.

Gene expression databases

BgeeiENSG00000141736.

Family and domain databases

Gene3Di3.80.20.20. 1 hit.
InterProiIPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF14843. GF_recep_IV. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DTR1_HUMAN
AccessioniPrimary (citable) accession number: B4DTR1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.