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Protein

Receptor protein-tyrosine kinase

Gene

ERBB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:ERBB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141736.13
HGNCiHGNC:3430 ERBB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei378 – 399HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141736

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501408512123 – 979Receptor protein-tyrosine kinaseSequence analysisAdd BLAST957

Proteomic databases

MaxQBiB4DTR1
PeptideAtlasiB4DTR1

Expressioni

Gene expression databases

BgeeiENSG00000141736

Structurei

3D structure databases

SMRiB4DTR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini444 – 711Protein kinaseInterPro annotationAdd BLAST268

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
GeneTreeiENSGT00760000118799
HOGENOMiHOG000230982
HOVERGENiHBG000490

Family and domain databases

Gene3Di3.80.20.201 hit
InterProiView protein in InterPro
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF14843 GF_recep_IV, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00261 FU, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

B4DTR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELAALCRWG LLLALLPPGA ASTQDNYLST DVGSCTLVCP LHNQEVTAED
60 70 80 90 100
GTQRCEKCSK PCARVCYGLG MEHLREVRAV TSANIQEFAG CKKIFGSLAF
110 120 130 140 150
LPESFDGDPA SNTAPLQPEQ LQVFETLEEI TGYLYISAWP DSLPDLSVFQ
160 170 180 190 200
NLQVIRGRIL HNGAYSLTLQ GLGISWLGLR SLRELGSGLA LIHHNTHLCF
210 220 230 240 250
VHTVPWDQLF RNPHQALLHT ANRPEDECVG EGLACHQLCA RGHCWGPGPT
260 270 280 290 300
QCVNCSQFLR GQECVEECRV LQGLPREYVN ARHCLPCHPE CQPQNGSVTC
310 320 330 340 350
FGPEADQCVA CAHYKDPPFC VARCPSGVKP DLSYMPIWKF PDEEGACQPC
360 370 380 390 400
PINCTHSCVD LDDKGCPAEQ RASPLTSIIS AVVGILLVVV LGVVFGILIK
410 420 430 440 450
RRQQKIRKYT MRRLLQETEL VEPLTPSGAM PNQAQMRILK ETELRKVKVL
460 470 480 490 500
GSGAFGTVYK GIWIPDGENV KIPVAIKVLR ENTSPKANKE ILDEAYVMAG
510 520 530 540 550
VGSPYVSRLL GICLTSTVQL VTQLMPYGCL LDHVRENRGR LGSQDLLNWC
560 570 580 590 600
MQIAKGMSYL EDVRLVHRDL AARNVLVKSP NHVKITDFGL ARLLDIDETE
610 620 630 640 650
YHADGGKVPI KWMALESILR RRFTHQSDVW SYGVTVWELM TFGAKPYDGI
660 670 680 690 700
PAREIPDLLE KGERLPQPPI CTIDVYMIMV KCWMIDSECR PRFRELVSEF
710 720 730 740 750
SRMARDPQRF VVIQNEDLGP ASPLDSTFYR SLLEDDDMGD LVDAEEYLVP
760 770 780 790 800
QQGFFCPDPA PGAGGMVHHR HRSSSTRSGG GDLTLGLEPS EEEAPRSPLA
810 820 830 840 850
PSEGAGSDVF DGDLGMGAAK GLQSLPTHDP SPLQRYSEDP TVPLPSETDG
860 870 880 890 900
YVAPLTCSPQ PEYVNQPDVR PQPPSPREGP LPAARPAGAT LERPKTLSPG
910 920 930 940 950
KNGVVKDVFA FGGAVENPEY LTPQGGAAPQ PHPPPAFSPA FDNLYYWDQD
960 970
PPERGAPPST FKGTPTAENP EYLGLDVPV
Length:979
Mass (Da):107,571
Last modified:September 23, 2008 - v1
Checksum:iF0015E7394171A14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079199 Genomic DNA No translation available.
AC087491 Genomic DNA No translation available.
AK300321 mRNA Translation: BAG62073.1
UniGeneiHs.446352

Genome annotation databases

EnsembliENST00000445658; ENSP00000404047; ENSG00000141736
UCSCiuc010wek.3 human

Similar proteinsi

Entry informationi

Entry nameiB4DTR1_HUMAN
AccessioniPrimary (citable) accession number: B4DTR1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported