B4DTM2 (B4DTM2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Intersectin-1 Ensembl ENSP00000382289

Submitted name:
cDNA FLJ61390, highly similar to Intersectin-1 EMBL BAG62034.1

Gene names

Name:

ITSN1 Ensembl ENSP00000382289

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAG62034.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1215 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 5 SH3 domains. RuleBase RU003338

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: InterPro
Cellular_component	plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4DTM2 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 9610DEBFC4781CED	FASTA	1,215	137,049
	10 20 30 40 50 60 MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 70 80 90 100 110 120 IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFGMGGI 130 140 150 160 170 180 ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV PTAAVPPLAN GAPPVIQPLP AFAHPAATLP 190 200 210 220 230 240 KSSSFSRSGP GSQLNTKLQK AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL 250 260 270 280 290 300 TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 310 320 330 340 350 360 PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF EDKKRENFER 370 380 390 400 410 420 GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE QERKRQLELE KQLEKQRELE 430 440 450 460 470 480 RQREEERRKE IERREAAKRE LERQRQLEWE RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF 490 500 510 520 530 540 ELEALNDKKH QLEGKLQDIR CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR 550 560 570 580 590 600 LIPEKQILND QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 610 620 630 640 650 660 DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ RRAQERDKQW 670 680 690 700 710 720 LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE AQDKLGRLFH QHQEPAKPAV 730 740 750 760 770 780 QAPWSTAEKG PLTISAQENV KVVYYRALYP FESRSHDEIT IQPGDIVMVD ESQTGEPGWL 790 800 810 820 830 840 GGELKGKTGW FPANYAEKIP ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST 850 860 870 880 890 900 TPNNWADFSS TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 910 920 930 940 950 960 VLGQGEKVEG LQAQALYPWR AKKDNHLNFN KNDVITVLEQ QDMWWFGEVQ GQKGWFPKSY 970 980 990 1000 1010 1020 VKLISGPIRK STSMDSGSSE SPASLKRVAS PAAKPVVSGE EFIAMYTYES SEQGDLTFQQ 1030 1040 1050 1060 1070 1080 GDVILVTKKD GDWWTGTVGD KAGVFPSNYV RLKDSEGSGT AGKTGSLGKK PEIAQVIASY 1090 1100 1110 1120 1130 1140 TATGPEQLTL APGQLILIRK KNPGGWWEGE LQARGKKRQI GWFPANYVKL LSPGTSKITP 1150 1160 1170 1180 1190 1200 TEPPKSTALA AVCQVIGMYD YTAQNDDELA FNKGQIINVL NKEDPDWWKG EVNGQVGLFP 1210 SNYVKLTTDM DPSQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 21." Chromosome 21 mapping and sequencing consortium Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL BAG62034.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000308 Genomic DNA. No translation available. AP000309 Genomic DNA. No translation available. AP000310 Genomic DNA. No translation available. AP000311 Genomic DNA. No translation available. AP000312 Genomic DNA. No translation available. AP000313 Genomic DNA. No translation available. AK300274 mRNA. Translation: BAG62034.1.
IPI	IPI00829634.
UniGene	Hs.160324.
3D structure databases
SMR	B4DTM2. Positions 1-111, 210-312, 745-830, 908-1215.
ModBase	Search...
Proteomic databases
PRIDE	B4DTM2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000399352; ENSP00000382289; ENSG00000205726.
UCSC	uc002ysy.3. human.
Organism-specific databases
HGNC	HGNC:6183. ITSN1.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000010175.
HOVERGEN	HBG052159.
Gene expression databases
ArrayExpress	B4DTM2.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR000261. EPS15_homology. IPR026813. ITSN1. IPR011511. SH3_2. IPR001452. SH3_domain. IPR013315. Spectrin_alpha_SH3. [Graphical view]
PANTHER	PTHR11216:SF28. PTHR11216:SF28. 1 hit.
Pfam	PF00018. SH3_1. 3 hits. PF07653. SH3_2. 2 hits. [Graphical view]
PRINTS	PR00452. SH3DOMAIN. PR01887. SPECTRNALPHA.
SMART	SM00054. EFh. 2 hits. SM00027. EH. 2 hits. SM00326. SH3. 5 hits. [Graphical view]
SUPFAM	SSF50044. SH3. 5 hits.
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS50031. EH. 2 hits. PS50002. SH3. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35474971.

Entry information

Entry name

B4DTM2_HUMAN

Accession

Primary (citable) accession number: B4DTM2

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.