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Protein

Carboxylic ester hydrolase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Protein family/group databases

ESTHERihuman-CEL. Cholesterol_esterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiB4DSX9.
PeptideAtlasiB4DSX9.
PRIDEiB4DSX9.

Structurei

3D structure databases

ProteinModelPortaliB4DSX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 422COesteraseInterPro annotationAdd BLAST422
Domaini435 – 517Mucin-likeInterPro annotationAdd BLAST83

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
HOVERGENiHBG008839.
KOiK12298.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR033560. BAL.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR032059. Mucin-like.
PANTHERiPTHR11559:SF293. PTHR11559:SF293. 1 hit.
PfamiView protein in Pfam
PF00135. COesterase. 1 hit.
PF16058. Mucin-like. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00122. CARBOXYLESTERASE_B_1. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DSX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWIYGGAFL MGSGHGANFL NNYLYDGEEI ATRGNVIVVT FNYRVGPLGF
60 70 80 90 100
LSTGDANLPG NYGLRDQHMA IAWVKRNIAA FGGDPNNITL FGESAGGASV
110 120 130 140 150
SLQTLSPYNK GLIRRAISQS GVALSPWVIQ KNPLFWAKKV AEKVGCPVGD
160 170 180 190 200
AARMAQCLKV TDPRALTLAY KVPLAGLEYP MLHYVGFVPV IDGDFIPADP
210 220 230 240 250
INLYANAADI DYIAGTNNMD GHIFASIDMP AINKGNKKVT EEDFYKLVSE
260 270 280 290 300
FTITKGLRGA KTTFDVYTES WAQDPSQENK KKTVVDFETD VLFLVPTEIA
310 320 330 340 350
LAQHRANAKS AKTYAYLFSH PSRMPVYPKW VGADHADDIQ YVFGKPFATP
360 370 380 390 400
TGYRPQDRTV SKAMIAYWTN FAKTGDPNMG DSAVPTHWEP YTTENSGYLE
410 420 430 440 450
ITKKMGSSSM KRSLRTNFLR YWTLTYLALP TVTDQEATPV PPTGDSEATP
460 470 480 490 500
VPPTGDSETA PVPPTGDSGA PPVPPTGDSG APPVPPTGDS GAPPVPPTGD
510 520
SGAPPVPPTG DSGAPPRAAH G
Length:521
Mass (Da):55,909
Last modified:September 23, 2008 - v1
Checksum:i9AA18B4E89656285
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299965 mRNA. Translation: BAG61791.1.
RefSeqiNP_001798.2. NM_001807.4.
UniGeneiHs.533258.

Genome annotation databases

GeneIDi1056.
KEGGihsa:1056.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB4DSX9_HUMAN
AccessioniPrimary (citable) accession number: B4DSX9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 5, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.