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Protein
Submitted name:

cDNA FLJ58078, highly similar to Tyrosine-protein phosphatase non-receptortype 23 (EC 3.1.3.48)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ58078, highly similar to Tyrosine-protein phosphatase non-receptortype 23 (EC 3.1.3.48)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

MaxQBiB4DST5.
PaxDbiB4DST5.
PeptideAtlasiB4DST5.
PRIDEiB4DST5.

Expressioni

Gene expression databases

BgeeiENSG00000076201.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265562.

Structurei

3D structure databases

ProteinModelPortaliB4DST5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 268268BRO1InterPro annotationAdd
BLAST
Domaini1094 – 1326233Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1239 – 131779TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili430 – 45728Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
KOG2220. Eukaryota.
ENOG410XQX6. LUCA.
HOGENOMiHOG000012993.
HOVERGENiHBG082231.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR028770. PTPN23.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR19134:SF333. PTHR19134:SF333. 2 hits.
PfamiPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DST5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAMDKRVS EEGMKVSCTH FQCAAGAFAY LREHFPQAYS VDMSRQILTL
60 70 80 90 100
NVNLMLGQAQ ECLLEKSMLD NRKSFLVARI SAQVVDYYKE ACRALENPDT
110 120 130 140 150
ASLLGRIQKD WKKLVQMKIY YFAAVAHLHM GKQAEEQQKF GERVAYFQSA
160 170 180 190 200
LDKLNEAIKL AKGQPDTVQD ALRFTMDVIG GKYNSAKKDN DFIYHEAVPA
210 220 230 240 250
LDTLQPVKGA PLVKPLPVNP TDPAVTGPDI FAKLVPMAAH EASSLYSEEK
260 270 280 290 300
AKLLREMMAK IEDKNEVLDQ FMDSMQLDPE TVDNLDAYSH IPPQLMEKCA
310 320 330 340 350
ALSVRPDTVR NLVQSMQVLS GVFTDVEASL KDIRDLLEED ELLEQKFQEA
360 370 380 390 400
VGQAGAISIT SKAELAEVRR EWAKYMEVHE KASFTNSELH RAMNLHVGNL
410 420 430 440 450
RLLSGPLDQV RAALPTPALS PEDKAVLQNL KRILAKVQEM RDQRVSLEQQ
460 470 480 490 500
LRELIQKDDI TASLVTTDHS EMKKLFEEQL KKYDQLKVYL EQNLAAQDRV
510 520 530 540 550
LCALTEANVQ YAAVRRVLSD LDQKWNSTLQ TLVASYEAYE DLMKKSQEGR
560 570 580 590 600
DFYADLESKV AALLERTQST CQAREAARQQ LLDRELKKKP PPRPTAPKPL
610 620 630 640 650
LPRREESEAV EAGDPPEELR SLPPDMVAGP RLPDTFLGSA TPLHFPPSPF
660 670 680 690 700
PSSTGPGPHY LSGPLPPGTY SGPTQLIQPR APGPHAMPVA PGPALYPAPA
710 720 730 740 750
YTPELGLVPR SSPQHGVVSS PYVGVGPAPP VAGLPSAPPP QFSGPELAMA
760 770 780 790 800
VRPATTTVDS IQAPIPSHTA PRPNPTPAPP PPCFPVPPPQ PLPTPYTYPA
810 820 830 840 850
GAKQPIPAQH HFSSGIPAGF PAPRIGPQPQ PHPQPHPSQA FGPQPPQQPL
860 870 880 890 900
PLQHPHLFPP QAPGLLPPQS PYPYAPQPGV LGQPPPPLHT QLYPGPAQDP
910 920 930 940 950
LPAHSGALPF PSPGPPQPPH PPLAYGPAPS TRPMGPQAAP LTIRGPSSAG
960 970 980 990 1000
QSTPSPHLVP SPAPSPGPGP VPPRPPAAEP PPCLRRGAAA ADLLSSSPES
1010 1020 1030 1040 1050
QHGGTQSPGG GQPLLQPTKV DAAEGRRPQA LRLIERDPYE HPERLRQLQQ
1060 1070 1080 1090 1100
ELEAFRGQLG DVGALDTVWR ELQDAQEHDA RGRSIAIARC YSLKNRHQDV
1110 1120 1130 1140 1150
MPYDSNRVVL RSGKDDYINA SCVEGLSPYC PPLVATQAPL PGTAADFWLM
1160 1170 1180 1190 1200
VHEQKVSVIV MLVSEAEMEK QKVARYFPTE RGQPMVHGAL SLALSSVRST
1210 1220 1230 1240 1250
ETHVERVLSL QFRDQSLKRS LVHLHFPTWP ELGLPDSPSN LLRFIQEVHA
1260 1270 1280 1290 1300
HYLHQRPLHT PIIVHCSSGV GRTGAFALLY AAVQEVEAGN GIPELPQLVR
1310 1320 1330 1340 1350
RMRQQRKHML QEKLHLRFCY EAVVRHVEQV LQRHGVPPPC KPLASASISQ
1360 1370 1380 1390 1400
KNHLPQDSQD LVLGGDVPIS SIQATIAKLS IRPPGGLESP VASLPGPAEP
1410 1420 1430 1440 1450
PGLPPASLPE STPIPSSSPP PLSSPLPEAP QPKEEPPVPE APSSGPPSSS
1460 1470 1480 1490 1500
LELLASLTPE AFSLDSSLRG KQRMSKHNFL QAHNGQGLRA TRPSDDPLSL
1510
LDPLWTLNKT
Length:1,510
Mass (Da):164,567
Last modified:September 23, 2008 - v1
Checksum:i9FF204F75DEBA060
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299906 mRNA. Translation: BAG61747.1.
RefSeqiNP_001291411.1. NM_001304482.1.
UniGeneiHs.25524.

Genome annotation databases

GeneIDi25930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299906 mRNA. Translation: BAG61747.1.
RefSeqiNP_001291411.1. NM_001304482.1.
UniGeneiHs.25524.

3D structure databases

ProteinModelPortaliB4DST5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265562.

Proteomic databases

MaxQBiB4DST5.
PaxDbiB4DST5.
PeptideAtlasiB4DST5.
PRIDEiB4DST5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25930.

Organism-specific databases

CTDi25930.

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
KOG2220. Eukaryota.
ENOG410XQX6. LUCA.
HOGENOMiHOG000012993.
HOVERGENiHBG082231.

Miscellaneous databases

ChiTaRSiPTPN23. human.
GenomeRNAii25930.

Gene expression databases

BgeeiENSG00000076201.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR028770. PTPN23.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR19134:SF333. PTHR19134:SF333. 2 hits.
PfamiPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DST5_HUMAN
AccessioniPrimary (citable) accession number: B4DST5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.