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Protein

Tyrosine-protein phosphatase non-receptor type

Gene

PTPN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108SubstrateUniRule annotation1
Active sitei142Phosphocysteine intermediateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseUniRule annotationSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:PTPN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9642. PTPN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei336 – 357HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196396.

PTM / Processingi

Proteomic databases

MaxQBiB4DSN5.
PeptideAtlasiB4DSN5.
PRIDEiB4DSN5.

Expressioni

Gene expression databases

BgeeiENSG00000196396.
ExpressionAtlasiB4DSN5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360683.

Structurei

3D structure databases

ProteinModelPortaliB4DSN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 204Tyrosine-protein phosphataseInterPro annotationAdd BLAST204
Domaini116 – 195TYR_PHOSPHATASE_2InterPro annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni142 – 148Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOVERGENiHBG008321.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR012265. Ptpn1/Ptpn2.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DSN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAQRSYIL TQGPLPNTCG HFWEMVWEQK SRGVVMLNRV MEKGSLKCAQ
60 70 80 90 100
YWPQKEEKEM IFEDTNLKLT LISEDIKSYY TVRQLELENL TTQETREILH
110 120 130 140 150
FHYTTWPDFG VPESPASFLN FLFKVRESGS LSPEHGPVVV HCSAGIGRSG
160 170 180 190 200
TFCLADTCLL LMDKRKDPSS VDIKKVLLEM RKFRMGLIQT ADQLRFSYLA
210 220 230 240 250
VIEGAKFIMG DSSVQDQWKE LSHEDLEPPP EHIPPPPRPP KRILEPHNGK
260 270 280 290 300
CREFFPNHQW VKEETQEDKD CPIKEEKGSP LNAAPYGIES MSQDTEVRSR
310 320 330 340 350
VVGGSLRGAQ AASPAKGEPS LPEKDEDHAL SYWKPFLVNM CVATVLTAGA
360
YLCYRFLFNS NT
Length:362
Mass (Da):41,260
Last modified:September 23, 2008 - v1
Checksum:iC4611A4F5A4B5982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034429 Genomic DNA. No translation available.
AL133230 Genomic DNA. No translation available.
KF456940 Genomic DNA. No translation available.
AK299830 mRNA. Translation: BAG61697.1.
RefSeqiNP_001265547.1. NM_001278618.1.
UniGeneiHs.417549.

Genome annotation databases

EnsembliENST00000541713; ENSP00000437732; ENSG00000196396.
GeneIDi5770.
UCSCiuc010zys.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034429 Genomic DNA. No translation available.
AL133230 Genomic DNA. No translation available.
KF456940 Genomic DNA. No translation available.
AK299830 mRNA. Translation: BAG61697.1.
RefSeqiNP_001265547.1. NM_001278618.1.
UniGeneiHs.417549.

3D structure databases

ProteinModelPortaliB4DSN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360683.

Proteomic databases

MaxQBiB4DSN5.
PeptideAtlasiB4DSN5.
PRIDEiB4DSN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541713; ENSP00000437732; ENSG00000196396.
GeneIDi5770.
UCSCiuc010zys.4. human.

Organism-specific databases

CTDi5770.
HGNCiHGNC:9642. PTPN1.
OpenTargetsiENSG00000196396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOVERGENiHBG008321.

Miscellaneous databases

ChiTaRSiPTPN1. human.
GenomeRNAii5770.

Gene expression databases

BgeeiENSG00000196396.
ExpressionAtlasiB4DSN5. baseline and differential.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR012265. Ptpn1/Ptpn2.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DSN5_HUMAN
AccessioniPrimary (citable) accession number: B4DSN5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.