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B4DS76

- B4DS76_HUMAN

UniProt

B4DS76 - B4DS76_HUMAN

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Protein
Submitted name: Mitogen-activated protein kinase kinase kinase 11
Gene
MAP3K11
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. JUN kinase kinase kinase activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cell death Source: Ensembl
  2. positive regulation of neuron apoptotic process Source: Ensembl
  3. protein autophosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 11Imported
Submitted name:
cDNA FLJ53177, highly similar to Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25)Imported
Submitted name:
cDNA, FLJ78931, highly similar to Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25)Imported
Gene namesi
Name:MAP3K11Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6850. MAP3K11.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG067662.
OrthoDBiEOG7D85VN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DS76-1 [UniParc]FASTAAdd to Basket

« Hide

MEHKTLKITD FGLAREWHKT TQMSAAGTYA WMAPEVIKAS TFSKGSDVWS    50
FGVLLWELLT GEVPYRGIDC LAVAYGVAVN KLTLPIPSTC PEPFAQLMAD 100
CWAQDPHRRP DFASILQQLE ALEAQVLREM PRDSFHSMQE GWKREIQGLF 150
DELRAKEKEL LSREEELTRA AREQRSQAEQ LRRREHLLAQ WELEVFEREL 200
TLLLQQVDRE RPHVRRRRGT FKRSKLRARD GGERISMPLD FKHRITVQAS 250
PGLDRRRNVF EVGPGDSPTF PRFRAIQLEP AEPGQAWGRQ SPRRLEDSSN 300
GERRACWAWG PSSPKPGEAQ NGRRRSRMDE ATWYLDSDDS SPLGSPSTPP 350
ALNGNPPRPS LEPEEPKRPV PAERGSSSGT PKLIQRALLR GTALLASLGL 400
GRDLQPPGGP GRERGESPTT PPTPTPAPCP TEPPPSPLIC FSLKTPDSPP 450
TPAPLLLDLG IPVGQRSAKS PRREEEPRGG TVSPPPGTSR SAPGTPGTPR 500
SPPLGLISRP RPSPLRSRID PWSFVSAGPR PSPLPSPQPA PRRAPWTLFP 550
DSDPFWDSPP ANPFQGGPQD CRAQTKDMGA QAPWVPEAGP 590
Length:590
Mass (Da):65,344
Last modified:September 23, 2008 - v1
Checksum:iC7C24CA0C053133D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001362 Genomic DNA. No translation available.
AK299609 mRNA. Translation: BAG61538.1.
AK316032 mRNA. Translation: BAH14403.1.
UniGeneiHs.502872.

Genome annotation databases

EnsembliENST00000530153; ENSP00000433886; ENSG00000173327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001362 Genomic DNA. No translation available.
AK299609 mRNA. Translation: BAG61538.1 .
AK316032 mRNA. Translation: BAH14403.1 .
UniGenei Hs.502872.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000530153 ; ENSP00000433886 ; ENSG00000173327 .

Organism-specific databases

HGNCi HGNC:6850. MAP3K11.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG067662.
OrthoDBi EOG7D85VN.

Miscellaneous databases

NextBioi 35474584.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Caudate nucleusImported.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB4DS76_HUMAN
AccessioniPrimary (citable) accession number: B4DS76
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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