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Protein

Ubiquitin thioesterase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei125UniRule annotation1
Active sitei128NucleophileUniRule annotation1
Active sitei302UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin thioesteraseUniRule annotation (EC:3.4.19.12UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiB4DPD5.
PaxDbiB4DPD5.
PeptideAtlasiB4DPD5.
PRIDEiB4DPD5.

Interactioni

Protein-protein interaction databases

IntActiB4DPD5. 2 interactors.
STRINGi9606.ENSP00000402551.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 308OTUInterPro annotationAdd BLAST192

Sequence similaritiesi

Belongs to the peptidase C65 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3991. Eukaryota.
ENOG410ZMN7. LUCA.
HOGENOMiHOG000019496.
HOVERGENiHBG053383.

Family and domain databases

InterProiIPR003323. OTU_dom.
IPR030298. OTUB1.
IPR016615. Otubain.
IPR019400. Peptidase_C65_otubain.
[Graphical view]
PANTHERiPTHR12931:SF19. PTHR12931:SF19. 1 hit.
PfamiPF10275. Peptidase_C65. 1 hit.
[Graphical view]
PIRSFiPIRSF013503. Ubiquitin_thioesterase_Otubain. 1 hit.
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DPD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGVEGCCQG GATRRGSLPG GRQLATRKRS VVRRCLKMAA EEPQQQKQEP
60 70 80 90 100
LGSDSEGVNC LAYDEAIMAQ QDRIQQEIAV QNPLVSERLE LSVLYKEYAE
110 120 130 140 150
DDNIYQQKIK DLHKKYSYIR KTRPDGNCFY RAFGFSHLEA LLDDSKELQR
160 170 180 190 200
FKAVSAKSKE DLVSQGFTEL TIEDFHNTFM DLIEQVEKQT SVADLLASFN
210 220 230 240 250
DQSTSDYLVV YLRLLTSGYL QRESKFFEHF IEGGRTVKEF CQQEVEPMCK
260 270 280 290 300
ESDHIHIIAL AQALSVSIQV EYMDRGEGGT TNPHIFPEGS EPKVYLLYRP

GHYDILYK
Length:308
Mass (Da):35,181
Last modified:September 23, 2008 - v1
Checksum:iBFF9F3468240EC8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298287 mRNA. Translation: BAG60547.1.
UniGeneiHs.473788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298287 mRNA. Translation: BAG60547.1.
UniGeneiHs.473788.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB4DPD5. 2 interactors.
STRINGi9606.ENSP00000402551.

Proteomic databases

MaxQBiB4DPD5.
PaxDbiB4DPD5.
PeptideAtlasiB4DPD5.
PRIDEiB4DPD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3991. Eukaryota.
ENOG410ZMN7. LUCA.
HOGENOMiHOG000019496.
HOVERGENiHBG053383.

Family and domain databases

InterProiIPR003323. OTU_dom.
IPR030298. OTUB1.
IPR016615. Otubain.
IPR019400. Peptidase_C65_otubain.
[Graphical view]
PANTHERiPTHR12931:SF19. PTHR12931:SF19. 1 hit.
PfamiPF10275. Peptidase_C65. 1 hit.
[Graphical view]
PIRSFiPIRSF013503. Ubiquitin_thioesterase_Otubain. 1 hit.
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DPD5_HUMAN
AccessioniPrimary (citable) accession number: B4DPD5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.