B4DNM4 (B4DNM4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Aurora kinase B Ensembl ENSP00000443869

Submitted name:
cDNA FLJ57406, highly similar to Serine/threonine-protein kinase 12 (EC 2.7.11.1) EMBL BAG60286.1

Gene names

Name:

AURKB Ensembl ENSP00000443869

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAG60286.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase EMBL BAG60286.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara cell cycle Inferred from electronic annotation. Source: Compara cell proliferation Inferred from electronic annotation. Source: Compara cytokinesis Inferred from electronic annotation. Source: Compara
Cellular_component	chromocenter Inferred from electronic annotation. Source: Compara chromosome passenger complex Inferred from electronic annotation. Source: Compara midbody Inferred from electronic annotation. Source: Compara spindle Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4DNM4 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 301BAFF2494B3650	FASTA	303	34,760
	10 20 30 40 50 60 MSRSNVQPTA APGQKVMENS SGTPDILTRH FTIDDFEIGR PLGKGKFGNV YLAREKKSHF 70 80 90 100 110 120 IVALKVLFKS QIEKEGVEHQ LRREIEIQAH LHHPNILRLY NYFYDRRRIY LILEYAPRGE 130 140 150 160 170 180 LYKELQKSCT FDEQRTATIM EELADALMYC HGKKVIHRDI KPENLLLGLK GELKIADFGW 190 200 210 220 230 240 SVHAPSLRRK TMCGTLDYLP PEMIEGRMHN EKVDLWCIGV LCYELLVGNP PFESASHNET 250 260 270 280 290 300 YRRIVKVDLK FPASVPMGAQ DLISKLLRHN PSERLPLAQV SAHPWVRANS RRVLPPSALQ SVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC135178 Genomic DNA. No translation available. AK297976 mRNA. Translation: BAG60286.1.
IPI	IPI01011339.
RefSeq	NP_001243763.1. NM_001256834.1.
UniGene	Hs.442658.
3D structure databases
SMR	B4DNM4. Positions 29-297.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000534871; ENSP00000443869; ENSG00000178999.
GeneID	9212.
KEGG	hsa:9212.
UCSC	uc010cnu.3. human.
Organism-specific databases
CTD	9212.
HGNC	HGNC:11390. AURKB.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG108519.
KO	K11479.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9212.
NextBio	34535.

Entry information

Entry name

B4DNM4_HUMAN

Accession

Primary (citable) accession number: B4DNM4

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	May 29, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.