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B4DNK4

- B4DNK4_HUMAN

UniProt

B4DNK4 - B4DNK4_HUMAN

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Protein

Pyruvate kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. potassium ion binding Source: InterPro
  3. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiB4DNK4.

Expressioni

Gene expression databases

BgeeiB4DNK4.
ExpressionAtlasiB4DNK4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB4DNK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000008859.
HOGENOMiHOG000021559.
HOVERGENiHBG000941.
KOiK00873.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DNK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT
60 70 80 90 100
IGPASRSVEL KKGATLKITL DNAYMEKCDE NILWLDYKNI CKVVEVGSKI
110 120 130 140 150
YVDDGLISLQ VKQKGADFLV TEVENGGSLG SKKGVNLPGA AVDLPAVSEK
160 170 180 190 200
DIQDLKFGVE QDVDMVFASF IRKASDVHEV RKVLGEKGKN IKIISKIENH
210 220 230 240 250
EGVRRFDEIL EASDGIMVAR GDLGIEIPAE KVFLAQKMMI GRCNRAGKPV
260 270 280 290 300
ICATQMLESM IKKPRPTRAE GSDVANAVLD GADCIMLSGE TAKGDYPLEA
310 320 330 340 350
VRMQHLIARE AEAAIYHLQL FEELRRLAPI TSDPTEATAV GAVEASFKCC
360 370 380 390 400
SGAIIVLTKS GRSAHQVARY RPRAPIIAVT RNPQTARQAH LYRGIFPVLC
410 420 430 440 450
KDPVQEAWAE DVDLRVNFAM NVGKARGFFK KGDVVIVLTG WRPGSGFTNT

MRVVPVP
Length:457
Mass (Da):49,898
Last modified:September 23, 2008 - v1
Checksum:iFC7B2566EEDC7096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297951 mRNA. Translation: BAG60266.1.
RefSeqiNP_001193726.1. NM_001206797.1.
UniGeneiHs.534770.

Genome annotation databases

GeneIDi5315.
KEGGihsa:5315.
UCSCiuc010ukk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297951 mRNA. Translation: BAG60266.1 .
RefSeqi NP_001193726.1. NM_001206797.1.
UniGenei Hs.534770.

3D structure databases

ProteinModelPortali B4DNK4.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B4DNK4.

Protocols and materials databases

DNASUi 5315.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5315.
KEGGi hsa:5315.
UCSCi uc010ukk.2. human.

Organism-specific databases

CTDi 5315.

Phylogenomic databases

GeneTreei ENSGT00390000008859.
HOGENOMi HOG000021559.
HOVERGENi HBG000941.
KOi K00873.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Miscellaneous databases

GenomeRNAii 5315.
NextBioi 20554.

Gene expression databases

Bgeei B4DNK4.
ExpressionAtlasi B4DNK4. baseline and differential.

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB4DNK4_HUMAN
AccessioniPrimary (citable) accession number: B4DNK4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.