B4DNK4 (B4DNK4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Pyruvate kinase RuleBase RU000504 EC=2.7.1.40 RuleBase RU000504
Organism	Homo sapiens (Human) EMBL BAG60266.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + pyruvate = ADP + phosphoenolpyruvate. RuleBase RU000504
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. RuleBase RU000504
Sequence similarities	Belongs to the pyruvate kinase family. RuleBase RU000504

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU000504
Ligand	Magnesium RuleBase RU000504 Pyruvate EMBL BAG60266.1
Molecular function	Kinase RuleBase RU000504 EMBL BAG60266.1 Transferase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro potassium ion binding Inferred from electronic annotation. Source: InterPro pyruvate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4DNK4 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: FC7B2566EEDC7096	FASTA	457	49,898
	10 20 30 40 50 60 MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVEL 70 80 90 100 110 120 KKGATLKITL DNAYMEKCDE NILWLDYKNI CKVVEVGSKI YVDDGLISLQ VKQKGADFLV 130 140 150 160 170 180 TEVENGGSLG SKKGVNLPGA AVDLPAVSEK DIQDLKFGVE QDVDMVFASF IRKASDVHEV 190 200 210 220 230 240 RKVLGEKGKN IKIISKIENH EGVRRFDEIL EASDGIMVAR GDLGIEIPAE KVFLAQKMMI 250 260 270 280 290 300 GRCNRAGKPV ICATQMLESM IKKPRPTRAE GSDVANAVLD GADCIMLSGE TAKGDYPLEA 310 320 330 340 350 360 VRMQHLIARE AEAAIYHLQL FEELRRLAPI TSDPTEATAV GAVEASFKCC SGAIIVLTKS 370 380 390 400 410 420 GRSAHQVARY RPRAPIIAVT RNPQTARQAH LYRGIFPVLC KDPVQEAWAE DVDLRVNFAM 430 440 450 NVGKARGFFK KGDVVIVLTG WRPGSGFTNT MRVVPVP

References

[1]

"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK297951 mRNA. Translation: BAG60266.1.
IPI	IPI00847989.
RefSeq	NP_001193726.1. NM_001206797.1.
UniGene	Hs.534770.
3D structure databases
ProteinModelPortal	B4DNK4.
ModBase	Search...
Protein-protein interaction databases
STRING	B4DNK4.
Proteomic databases
PRIDE	B4DNK4.
Protocols and materials databases
DNASU	5315.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5315.
KEGG	hsa:5315.
UCSC	uc010ukk.2. human.
Organism-specific databases
CTD	5315.
Phylogenomic databases
HOGENOM	HOG000021559.
HOVERGEN	HBG000941.
KO	K00873.
Enzyme and pathway databases
UniPathway	UPA00109; UER00188.
Gene expression databases
ArrayExpress	B4DNK4.
Bgee	B4DNK4.
Family and domain databases
Gene3D	3.20.20.60. 1 hit. 3.40.1380.20. 1 hit.
InterPro	IPR001697. Pyr_Knase. IPR015813. Pyrv/PenolPyrv_Kinase. IPR011037. Pyrv_Knase-like_insert_dom. IPR015794. Pyrv_Knase_a/b. IPR018209. Pyrv_Knase_AS. IPR015793. Pyrv_Knase_brl. IPR015795. Pyrv_Knase_C. [Graphical view]
PANTHER	PTHR11817. PTHR11817. 1 hit.
Pfam	PF00224. PK. 1 hit. PF02887. PK_C. 1 hit. [Graphical view]
PRINTS	PR01050. PYRUVTKNASE.
SUPFAM	SSF50800. PK_B_barrel_like. 1 hit. SSF52935. Pyruvate_kinase. 1 hit. SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMs	TIGR01064. pyruv_kin. 1 hit.
PROSITE	PS00110. PYRUVATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5315.
NextBio	20554.

Entry information

Entry name

B4DNK4_HUMAN

Accession

Primary (citable) accession number: B4DNK4

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	March 6, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.