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Protein
Submitted name:

Tissue-type plasminogen activator

Gene

PLAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei231Charge relay systemUniRule annotation1
Active sitei280Charge relay systemUniRule annotation1
Active sitei387Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue-type plasminogen activatorImported
Submitted name:
cDNA FLJ59358, highly similar to Tissue-type plasminogen activator (EC 3.4.21.68)Imported
Gene namesi
Name:PLATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104368.17.
HGNCiHGNC:9051. PLAT.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501010542123 – 436Sequence analysisAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 170UniRule annotation
Disulfide bondi110 ↔ 152UniRule annotation
Disulfide bondi141 ↔ 165UniRule annotation
Disulfide bondi173 ↔ 304Interchain (between A and B chains)UniRule annotation
Disulfide bondi216 ↔ 232UniRule annotation
Disulfide bondi224 ↔ 293UniRule annotation
Disulfide bondi318 ↔ 393UniRule annotation
Disulfide bondi350 ↔ 366UniRule annotation
Disulfide bondi383 ↔ 411UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

MaxQBiB4DNJ1.

Expressioni

Gene expression databases

BgeeiENSG00000104368.
ExpressionAtlasiB4DNJ1. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 81Fibronectin type-IInterPro annotationAdd BLAST43
Domaini88 – 170KringleInterPro annotationAdd BLAST83
Domaini185 – 435Peptidase S1InterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOGENOMiHOG000237314.
HOVERGENiHBG008633.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR000083. Fibronectin_type1.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR026280. Tissue_plasm_act.
IPR034811. tPA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PANTHERiPTHR24256:SF341. PTHR24256:SF341. 1 hit.
PfamiView protein in Pfam
PF00039. fn1. 1 hit.
PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001145. Tissue_plasm_act. 2 hits.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00058. FN1. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiView protein in PROSITE
PS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DNJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY
60 70 80 90 100
QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKRNSDCY FGNGSAYRGT
110 120 130 140 150
HSLTESGASC LPWNSMILIG KVYTAQNPSA QALGLGKHNY CRNPDGDAKP
160 170 180 190 200
WCHVLKNRRL TWEYCDVPSC STCGLRQYSQ PQFRIKGGLF ADIASHPWQA
210 220 230 240 250
AIFAKHRRSP GERFLCGGIL ISSCWILSAA HCFQERFPPH HLTVILGRTY
260 270 280 290 300
RVVPGEEEQK FEVEKYIVHK EFDDDTYDND IALLQLKSDS SRCAQESSVV
310 320 330 340 350
RTVCLPPADL QLPDWTECEL SGYGKHEALS PFYSERLKEA HVRLYPSSRC
360 370 380 390 400
TSQHLLNRTV TDNMLCAGDT RSGGPQANLH DACQGDSGGP LVCLNDGRMT
410 420 430
LVGIISWGLG CGQKDVPGVY TKVTNYLDWI RDNMRP
Length:436
Mass (Da):49,080
Last modified:September 23, 2008 - v1
Checksum:i3B61FE55E84C156D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA. No translation available.
AC103724 Genomic DNA. No translation available.
AK297937 mRNA. Translation: BAG60253.1.
UniGeneiHs.491582.

Genome annotation databases

EnsembliENST00000429710; ENSP00000407861; ENSG00000104368.
UCSCiuc011lcn.2. human.

Similar proteinsi

Entry informationi

Entry nameiB4DNJ1_HUMAN
AccessioniPrimary (citable) accession number: B4DNJ1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 27, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported