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Protein
Submitted name:

Tissue-type plasminogen activator

Gene

PLAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei231Charge relay systemUniRule annotation1
Active sitei280Charge relay systemUniRule annotation1
Active sitei387Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue-type plasminogen activatorImported
Submitted name:
cDNA FLJ59358, highly similar to Tissue-type plasminogen activator (EC 3.4.21.68)Imported
Gene namesi
Name:PLATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9051. PLAT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500764055723 – 436Sequence analysisAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 170UniRule annotation
Disulfide bondi110 ↔ 152UniRule annotation
Disulfide bondi141 ↔ 165UniRule annotation
Disulfide bondi173 ↔ 304Interchain (between A and B chains)UniRule annotation
Disulfide bondi216 ↔ 232UniRule annotation
Disulfide bondi224 ↔ 293UniRule annotation
Disulfide bondi318 ↔ 393UniRule annotation
Disulfide bondi350 ↔ 366UniRule annotation
Disulfide bondi383 ↔ 411UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

MaxQBiB4DNJ1.
PeptideAtlasiB4DNJ1.
PRIDEiB4DNJ1.

Expressioni

Gene expression databases

BgeeiENSG00000104368.
ExpressionAtlasiB4DNJ1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000220809.

Structurei

3D structure databases

ProteinModelPortaliB4DNJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 81Fibronectin type-IInterPro annotationAdd BLAST43
Domaini88 – 170KringleInterPro annotationAdd BLAST83
Domaini185 – 435Peptidase S1InterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Contains 1 peptidase S1 domain.UniRule annotation

Keywords - Domaini

KringleSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOGENOMiHOG000237314.
HOVERGENiHBG008633.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR000083. Fibronectin_type1.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR026280. Tissue_plasm_act.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00039. fn1. 1 hit.
PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001145. Tissue_plasm_act. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00058. FN1. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DNJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY
60 70 80 90 100
QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKRNSDCY FGNGSAYRGT
110 120 130 140 150
HSLTESGASC LPWNSMILIG KVYTAQNPSA QALGLGKHNY CRNPDGDAKP
160 170 180 190 200
WCHVLKNRRL TWEYCDVPSC STCGLRQYSQ PQFRIKGGLF ADIASHPWQA
210 220 230 240 250
AIFAKHRRSP GERFLCGGIL ISSCWILSAA HCFQERFPPH HLTVILGRTY
260 270 280 290 300
RVVPGEEEQK FEVEKYIVHK EFDDDTYDND IALLQLKSDS SRCAQESSVV
310 320 330 340 350
RTVCLPPADL QLPDWTECEL SGYGKHEALS PFYSERLKEA HVRLYPSSRC
360 370 380 390 400
TSQHLLNRTV TDNMLCAGDT RSGGPQANLH DACQGDSGGP LVCLNDGRMT
410 420 430
LVGIISWGLG CGQKDVPGVY TKVTNYLDWI RDNMRP
Length:436
Mass (Da):49,080
Last modified:September 23, 2008 - v1
Checksum:i3B61FE55E84C156D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA. No translation available.
AC103724 Genomic DNA. No translation available.
AK297937 mRNA. Translation: BAG60253.1.
UniGeneiHs.491582.

Genome annotation databases

EnsembliENST00000429710; ENSP00000407861; ENSG00000104368.
UCSCiuc011lcn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA. No translation available.
AC103724 Genomic DNA. No translation available.
AK297937 mRNA. Translation: BAG60253.1.
UniGeneiHs.491582.

3D structure databases

ProteinModelPortaliB4DNJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000220809.

Proteomic databases

MaxQBiB4DNJ1.
PeptideAtlasiB4DNJ1.
PRIDEiB4DNJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429710; ENSP00000407861; ENSG00000104368.
UCSCiuc011lcn.2. human.

Organism-specific databases

HGNCiHGNC:9051. PLAT.
OpenTargetsiENSG00000104368.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOGENOMiHOG000237314.
HOVERGENiHBG008633.

Miscellaneous databases

ChiTaRSiPLAT. human.

Gene expression databases

BgeeiENSG00000104368.
ExpressionAtlasiB4DNJ1. baseline and differential.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR000083. Fibronectin_type1.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR026280. Tissue_plasm_act.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00039. fn1. 1 hit.
PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001145. Tissue_plasm_act. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00058. FN1. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DNJ1_HUMAN
AccessioniPrimary (citable) accession number: B4DNJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.