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Protein
Submitted name:

Tissue-type plasminogen activator

Gene

PLAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei231Charge relay systemUniRule annotation1
Active sitei280Charge relay systemUniRule annotation1
Active sitei387Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue-type plasminogen activatorImported
Submitted name:
cDNA FLJ59358, highly similar to Tissue-type plasminogen activator (EC 3.4.21.68)Imported
Gene namesi
Name:PLATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104368.17
HGNCiHGNC:9051 PLAT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104368

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501456768523 – 436Sequence analysisAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 170UniRule annotation
Disulfide bondi110 ↔ 152UniRule annotation
Disulfide bondi141 ↔ 165UniRule annotation
Disulfide bondi173 ↔ 304Interchain (between A and B chains)UniRule annotation
Disulfide bondi216 ↔ 232UniRule annotation
Disulfide bondi224 ↔ 293UniRule annotation
Disulfide bondi318 ↔ 393UniRule annotation
Disulfide bondi350 ↔ 366UniRule annotation
Disulfide bondi383 ↔ 411UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000104368

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 81Fibronectin type-IInterPro annotationAdd BLAST43
Domaini88 – 170KringleInterPro annotationAdd BLAST83
Domaini185 – 435Peptidase S1InterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119133
HOGENOMiHOG000237314
HOVERGENiHBG008633

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 1 hit
InterProiView protein in InterPro
IPR000083 Fibronectin_type1
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR026280 Tissue_plasm_act
IPR034811 tPA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PANTHERiPTHR44617 PTHR44617, 2 hits
PfamiView protein in Pfam
PF00039 fn1, 1 hit
PF00051 Kringle, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001145 Tissue_plasm_act, 2 hits
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00058 FN1, 1 hit
SM00130 KR, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS01253 FN1_1, 1 hit
PS51091 FN1_2, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

B4DNJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY
60 70 80 90 100
QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKRNSDCY FGNGSAYRGT
110 120 130 140 150
HSLTESGASC LPWNSMILIG KVYTAQNPSA QALGLGKHNY CRNPDGDAKP
160 170 180 190 200
WCHVLKNRRL TWEYCDVPSC STCGLRQYSQ PQFRIKGGLF ADIASHPWQA
210 220 230 240 250
AIFAKHRRSP GERFLCGGIL ISSCWILSAA HCFQERFPPH HLTVILGRTY
260 270 280 290 300
RVVPGEEEQK FEVEKYIVHK EFDDDTYDND IALLQLKSDS SRCAQESSVV
310 320 330 340 350
RTVCLPPADL QLPDWTECEL SGYGKHEALS PFYSERLKEA HVRLYPSSRC
360 370 380 390 400
TSQHLLNRTV TDNMLCAGDT RSGGPQANLH DACQGDSGGP LVCLNDGRMT
410 420 430
LVGIISWGLG CGQKDVPGVY TKVTNYLDWI RDNMRP
Length:436
Mass (Da):49,080
Last modified:September 23, 2008 - v1
Checksum:i3B61FE55E84C156D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA No translation available.
AC103724 Genomic DNA No translation available.
AK297937 mRNA Translation: BAG60253.1
UniGeneiHs.491582

Genome annotation databases

EnsembliENST00000429710; ENSP00000407861; ENSG00000104368
UCSCiuc011lcn.2 human

Similar proteinsi

Entry informationi

Entry nameiB4DNJ1_HUMAN
AccessioniPrimary (citable) accession number: B4DNJ1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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