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Protein
Submitted name:

Iron-sulfur cluster assembly enzyme ISCU, mitochondrial

Gene

ISCU

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Iron-sulfur cluster assembly enzyme ISCU, mitochondrialImported
Submitted name:
cDNA FLJ51257, highly similar to NifU-like N-terminal domain-containing protein, mitochondrialImported
Gene namesi
Name:ISCUImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29882. ISCU.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136003.

PTM / Processingi

Proteomic databases

EPDiB4DNC9.
MaxQBiB4DNC9.

Expressioni

Gene expression databases

BgeeiENSG00000136003.
ExpressionAtlasiB4DNC9. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 140NifU_NInterPro annotationAdd BLAST106

Sequence similaritiesi

Belongs to the NifU family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG3361. Eukaryota.
COG0822. LUCA.
GeneTreeiENSGT00390000015813.
HOVERGENiHBG052621.

Family and domain databases

CDDicd06664. IscU_like. 1 hit.
InterProiView protein in InterPro
IPR011339. ISC_FeS_clus_asmbl_IscU.
IPR002871. NIF_FeS_clus_asmbl_NifU_N.
PANTHERiPTHR10093. PTHR10093. 1 hit.
PfamiView protein in Pfam
PF01592. NifU_N. 1 hit.
TIGRFAMsiTIGR01999. iscU. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DNC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGAFRLR RAASALLLRS PRLPARELSA PARLYHKKVV DHYENPRNVG
60 70 80 90 100
SLDKTSKNVG TGLVGAPACG DVMKLQIQVD EKGKIVDARF KTFGCGSAIA
110 120 130 140 150
SSSLATEWVK GKTVEEALTI KNTDIAKELC LPPVKLHCSK SVLFPAEEKT

QLSP
Length:154
Mass (Da):16,555
Last modified:September 23, 2008 - v1
Checksum:i0524B4639B1B3E68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008119 Genomic DNA. No translation available.
FJ695196 Genomic DNA. No translation available.
AK297862 mRNA. Translation: BAG60191.1.
RefSeqiNP_001288069.1. NM_001301140.1.
NP_001306971.1. NM_001320042.1.
UniGeneiHs.615131.

Genome annotation databases

EnsembliENST00000535729; ENSP00000445598; ENSG00000136003.
ENST00000547005; ENSP00000446606; ENSG00000136003.
GeneIDi23479.
UCSCiuc010sxb.2. human.

Similar proteinsi

Entry informationi

Entry nameiB4DNC9_HUMAN
AccessioniPrimary (citable) accession number: B4DNC9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: August 30, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported