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Protein
Submitted name:

Iron-sulfur cluster assembly enzyme ISCU, mitochondrial

Gene

ISCU

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Iron-sulfur cluster assembly enzyme ISCU, mitochondrialImported
Submitted name:
cDNA FLJ51257, highly similar to NifU-like N-terminal domain-containing protein, mitochondrialImported
Gene namesi
Name:ISCUImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29882. ISCU.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136003.

PTM / Processingi

Proteomic databases

EPDiB4DNC9.
MaxQBiB4DNC9.
PeptideAtlasiB4DNC9.
PRIDEiB4DNC9.

Expressioni

Gene expression databases

BgeeiENSG00000136003.
ExpressionAtlasiB4DNC9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310623.

Structurei

3D structure databases

ProteinModelPortaliB4DNC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 140NifU_NInterPro annotationAdd BLAST106

Sequence similaritiesi

Belongs to the NifU family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG3361. Eukaryota.
COG0822. LUCA.
GeneTreeiENSGT00390000015813.
HOVERGENiHBG052621.

Family and domain databases

CDDicd06664. IscU_like. 1 hit.
InterProiIPR011339. ISC_FeS_clus_asmbl_IscU.
IPR002871. NIF_FeS_clus_asmbl_NifU_N.
[Graphical view]
PfamiPF01592. NifU_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01999. iscU. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DNC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGAFRLR RAASALLLRS PRLPARELSA PARLYHKKVV DHYENPRNVG
60 70 80 90 100
SLDKTSKNVG TGLVGAPACG DVMKLQIQVD EKGKIVDARF KTFGCGSAIA
110 120 130 140 150
SSSLATEWVK GKTVEEALTI KNTDIAKELC LPPVKLHCSK SVLFPAEEKT

QLSP
Length:154
Mass (Da):16,555
Last modified:September 23, 2008 - v1
Checksum:i0524B4639B1B3E68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008119 Genomic DNA. No translation available.
FJ695196 Genomic DNA. No translation available.
AK297862 mRNA. Translation: BAG60191.1.
RefSeqiNP_001288069.1. NM_001301140.1.
NP_001306971.1. NM_001320042.1.
UniGeneiHs.615131.

Genome annotation databases

EnsembliENST00000535729; ENSP00000445598; ENSG00000136003.
ENST00000547005; ENSP00000446606; ENSG00000136003.
GeneIDi23479.
UCSCiuc010sxb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008119 Genomic DNA. No translation available.
FJ695196 Genomic DNA. No translation available.
AK297862 mRNA. Translation: BAG60191.1.
RefSeqiNP_001288069.1. NM_001301140.1.
NP_001306971.1. NM_001320042.1.
UniGeneiHs.615131.

3D structure databases

ProteinModelPortaliB4DNC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310623.

Proteomic databases

EPDiB4DNC9.
MaxQBiB4DNC9.
PeptideAtlasiB4DNC9.
PRIDEiB4DNC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000535729; ENSP00000445598; ENSG00000136003.
ENST00000547005; ENSP00000446606; ENSG00000136003.
GeneIDi23479.
UCSCiuc010sxb.2. human.

Organism-specific databases

CTDi23479.
HGNCiHGNC:29882. ISCU.
OpenTargetsiENSG00000136003.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3361. Eukaryota.
COG0822. LUCA.
GeneTreeiENSGT00390000015813.
HOVERGENiHBG052621.

Miscellaneous databases

ChiTaRSiISCU. human.
GenomeRNAii23479.

Gene expression databases

BgeeiENSG00000136003.
ExpressionAtlasiB4DNC9. baseline and differential.

Family and domain databases

CDDicd06664. IscU_like. 1 hit.
InterProiIPR011339. ISC_FeS_clus_asmbl_IscU.
IPR002871. NIF_FeS_clus_asmbl_NifU_N.
[Graphical view]
PfamiPF01592. NifU_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01999. iscU. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4DNC9_HUMAN
AccessioniPrimary (citable) accession number: B4DNC9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.