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B4DN50

- B4DN50_HUMAN

UniProt

B4DN50 - B4DN50_HUMAN

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Protein

Gap junction protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotation

GO - Molecular functioni

  1. gap junction channel activity Source: Ensembl

GO - Biological processi

  1. adult heart development Source: Ensembl
  2. apoptotic process Source: Ensembl
  3. ATP transport Source: Ensembl
  4. atrial ventricular junction remodeling Source: Ensembl
  5. blood vessel morphogenesis Source: Ensembl
  6. cardiac conduction Source: Ensembl
  7. cell-cell junction organization Source: Ensembl
  8. cell-cell signaling Source: Ensembl
  9. cell communication by chemical coupling Source: Ensembl
  10. cell communication by electrical coupling Source: Ensembl
  11. cellular response to mechanical stimulus Source: Ensembl
  12. chronic inflammatory response Source: Ensembl
  13. embryonic digit morphogenesis Source: Ensembl
  14. endothelium development Source: Ensembl
  15. epithelial cell maturation Source: Ensembl
  16. heart looping Source: Ensembl
  17. in utero embryonic development Source: Ensembl
  18. lens development in camera-type eye Source: Ensembl
  19. milk ejection Source: Ensembl
  20. negative regulation of cardiac muscle cell proliferation Source: Ensembl
  21. negative regulation of DNA biosynthetic process Source: Ensembl
  22. negative regulation of endothelial cell proliferation Source: Ensembl
  23. negative regulation of gene expression Source: Ensembl
  24. negative regulation of wound healing Source: Ensembl
  25. neuron migration Source: Ensembl
  26. neuron projection morphogenesis Source: Ensembl
  27. osteoblast differentiation Source: Ensembl
  28. positive regulation of behavioral fear response Source: Ensembl
  29. positive regulation of cell communication by chemical coupling Source: Ensembl
  30. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  31. positive regulation of gene expression Source: Ensembl
  32. positive regulation of glomerular filtration Source: Ensembl
  33. positive regulation of insulin secretion Source: Ensembl
  34. positive regulation of protein catabolic process Source: Ensembl
  35. positive regulation of striated muscle tissue development Source: Ensembl
  36. positive regulation of vasoconstriction Source: Ensembl
  37. positive regulation of vasodilation Source: Ensembl
  38. protein oligomerization Source: Ensembl
  39. regulation of atrial cardiac muscle cell membrane depolarization Source: Ensembl
  40. regulation of bone mineralization Source: Ensembl
  41. regulation of bone remodeling Source: Ensembl
  42. regulation of calcium ion transport Source: Ensembl
  43. regulation of tight junction assembly Source: Ensembl
  44. regulation of ventricular cardiac muscle cell membrane depolarization Source: Ensembl
  45. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
  46. response to fluid shear stress Source: Ensembl
  47. response to glucose Source: Ensembl
  48. response to peptide hormone Source: Ensembl
  49. response to pH Source: Ensembl
  50. skeletal muscle tissue regeneration Source: Ensembl
  51. vascular transport Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation. Cell junctiongap junction SAAS annotation
Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. connexon complex Source: Ensembl
  3. contractile fiber Source: Ensembl
  4. cytosol Source: Ensembl
  5. early endosome Source: Ensembl
  6. fascia adherens Source: Ensembl
  7. Golgi apparatus Source: Ensembl
  8. integral component of membrane Source: UniProtKB-KW
  9. intermediate filament Source: Ensembl
  10. lateral plasma membrane Source: Ensembl
  11. lysosome Source: Ensembl
  12. membrane raft Source: Ensembl
  13. mitochondrial outer membrane Source: Ensembl
  14. multivesicular body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiB4DN50.
ExpressionAtlasiB4DN50. baseline and differential.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4DN50.
SMRiB4DN50. Positions 3-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG009576.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 2 hits.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DN50-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDWSALGKL LDKVQAYSTA GGKVWLSAWG DEQSAFRCNT QQPGCENVCY
60 70 80 90 100
DKSFPISHVR FWVLQIIFVS VPTLLYLAHV FYVMRKEEKL NKKEEELKVA
110 120 130 140 150
QTDGVNVDMH LKQIEIKKFK YGIEEHGKVK MRGGLLRTYI ISILFKSIFE
160 170 180 190 200
VAFLLIQWYI YGFSLSAVYT CKRDPCPHQV DCFLSRPTEK TIFIIFMLVV
210 220 230 240 250
SLVSLALNII ELFYVFFKGV KDRVKGKSDP YHATSGALSP AKDCGSQKYA
260 270 280 290 300
YFNGCSSPTA PLSPMSPPGY KLVTGDRNNS SCRNYNKQAS EQNWANYSAE
310 320 330 340 350
QNRMGQAGST ISNSHAQPFD FPDDNQNSKK LAAGHELQPL AIVDQRPSSR
360
ASSRASSRPR PDDLEI
Length:366
Mass (Da):41,235
Last modified:September 23, 2008 - v1
Checksum:i0159852377FA7B09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297764 mRNA. Translation: BAG60112.1.
UniGeneiHs.700699.
Hs.74471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297764 mRNA. Translation: BAG60112.1 .
UniGenei Hs.700699.
Hs.74471.

3D structure databases

ProteinModelPortali B4DN50.
SMRi B4DN50. Positions 3-366.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009576.

Miscellaneous databases

NextBioi 35473510.

Gene expression databases

Bgeei B4DN50.
ExpressionAtlasi B4DN50. baseline and differential.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 2 hits.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB4DN50_HUMAN
AccessioniPrimary (citable) accession number: B4DN50
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.