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Protein
Submitted name:

Tissue-type plasminogen activator

Gene

PLAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei102Important for binding to LRP1UniRule annotation1
Active sitei268Charge relay systemUniRule annotation1
Active sitei317Charge relay systemUniRule annotation1
Sitei375Important for single-chain activityUniRule annotation1
Sitei423Important for single-chain activityUniRule annotation1
Active sitei424Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue-type plasminogen activatorImported
Submitted name:
cDNA FLJ59355, highly similar to Tissue-type plasminogen activator (EC 3.4.21.68)Imported
Gene namesi
Name:PLATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9051. PLAT.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501010541823 – 473Sequence analysisAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 71UniRule annotation
Disulfide bondi69 ↔ 78UniRule annotation
Disulfide bondi86 ↔ 97UniRule annotation
Disulfide bondi91 ↔ 108UniRule annotation
Disulfide bondi110 ↔ 119UniRule annotation
Disulfide bondi126 ↔ 207UniRule annotation
Disulfide bondi147 ↔ 189UniRule annotation
Disulfide bondi178 ↔ 202UniRule annotation
Disulfide bondi210 ↔ 341Interchain (between A and B chains)UniRule annotation
Disulfide bondi253 ↔ 269UniRule annotation
Disulfide bondi261 ↔ 330UniRule annotation
Disulfide bondi355 ↔ 430UniRule annotation
Disulfide bondi387 ↔ 403UniRule annotation
Disulfide bondi420 ↔ 448UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

MaxQBiB4DN26.

Expressioni

Gene expression databases

BgeeiENSG00000104368.
ExpressionAtlasiB4DN26. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 81Fibronectin type-IInterPro annotationAdd BLAST43
Domaini82 – 120EGF-likeInterPro annotationAdd BLAST39
Domaini125 – 207KringleInterPro annotationAdd BLAST83
Domaini222 – 472Peptidase S1InterPro annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 52Important for binding to annexin A2UniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000119133.
HOGENOMiHOG000237314.
HOVERGENiHBG008633.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000083. Fibronectin_type1.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR026280. Tissue_plasm_act.
IPR034811. tPA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PANTHERiPTHR24256:SF341. PTHR24256:SF341. 1 hit.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00039. fn1. 1 hit.
PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001145. Tissue_plasm_act. 2 hits.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00058. FN1. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DN26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY
60 70 80 90 100
QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA
110 120 130 140 150
LYFSDFVCQC PEGFAGKCCE IGNSDCYFGN GSAYRGTHSL TESGASCLPW
160 170 180 190 200
NSMILIGKVY TAQNPSAQAL GLGKHNYCRN PDGDAKPWCH VLKNRRLTWE
210 220 230 240 250
YCDVPSCSTC GLRQYSQPQF RIKGGLFADI ASHPWQAAIF AKHRRSPGER
260 270 280 290 300
FLCGGILISS CWILSAAHCF QERFPPHHLT VILGRTYRVV PGEEEQKFEV
310 320 330 340 350
EKYIVHKEFD DDTYDNDIAL LQLKSDSSRC AQESSVVRTV CLPPADLQLP
360 370 380 390 400
DWTECELSGY GKHEALSPFY SERLKEAHVR LYPSSRCTSQ HLLNRTVTDN
410 420 430 440 450
MLCAGDTRSG GPQANLHDAC QGDSGGPLVC LNDGRMTLVG IISWGLGCGQ
460 470
KDVPGVYTKV TNYLDWIRDN MRP
Length:473
Mass (Da):52,992
Last modified:September 23, 2008 - v1
Checksum:iAC4FB758DDF91A1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA. No translation available.
AC103724 Genomic DNA. No translation available.
AK297738 mRNA. Translation: BAG60088.1.
RefSeqiNP_001306118.1. NM_001319189.1.
UniGeneiHs.491582.

Genome annotation databases

EnsembliENST00000524009; ENSP00000429401; ENSG00000104368.
GeneIDi5327.
UCSCiuc011lcm.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB4DN26_HUMAN
AccessioniPrimary (citable) accession number: B4DN26
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported