B4DN15 (B4DN15_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ55228, highly similar to Interstitial collagenase (EC 3.4.24.7) EMBL BAG60077.1
Organism	Homo sapiens (Human) EMBL BAG60077.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 4 hemopexin-like domains. SAAS SAAS018486

Ontologies

Keywords
Domain	Collagen EMBL BAG60077.1 Repeat SAAS SAAS018486
Ligand	Calcium SAAS SAAS018486 Metal-binding SAAS SAAS018486 Zinc SAAS SAAS018486
Molecular function	Hydrolase Metalloprotease SAAS SAAS018486 Protease
PTM	Disulfide bond SAAS SAAS018486
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	153	1	By similarity PIRSR PIRSR001191-1

Sequences

	Sequence		Length	Mass (Da)
	B4DN15 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 1004B620F5E64475	FASTA	403	46,266
	10 20 30 40 50 60 MQEFFGLKVT GKPDAETLKV MKQPRCGVPD VAQFVLTEGN PRWEQTHLTY RIENYTPDLP 70 80 90 100 110 120 RADVDHAIEK AFQLWSNVTP LTFTKVSEGQ ADIMISFVRG DHRDNSPFDG PGGNLAHAFQ 130 140 150 160 170 180 PGPGIGGDAH FDEDERWTNN FREYNLHRVA AHELGHSLGL SHSTDIGALM YPSYTFSGDV 190 200 210 220 230 240 QLAQDDIDGI QAIYGRSQNP VQPIGPQTPK ACDSKLTFDA ITTIRGEVMF FKDRFYMRTN 250 260 270 280 290 300 PFYPEVELNF ISVFWPQLPN GLEAAYEFAD RDEVRFFKGN KYWAVQGQNV LHGYPKDIYS 310 320 330 340 350 360 SFGFPRTVKH IDAALSEENT GKTYFFVANK YWRYDEYKRS MDPGYPKMIA HDFPGIGHKV 370 380 390 400 DAVFMKDGFF YFFHGTRQYK FDPKTKRILT LQKANSWFNC RKN

References

[1]

"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK297723 mRNA. Translation: BAG60077.1.
IPI	IPI00924810.
RefSeq	NP_001139410.1. NM_001145938.1.
UniGene	Hs.83169.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B4DN15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4312.
KEGG	hsa:4312.
Organism-specific databases
CTD	4312.
PharmGKB	PA30867.
Phylogenomic databases
HOVERGEN	HBG052484.
Gene expression databases
Bgee	B4DN15.
Family and domain databases
InterPro	IPR000585. Hemopexin/matrixin. IPR018486. Hemopexin/matrixin_CS. IPR018487. Hemopexin/matrixin_repeat. IPR024079. MetalloPept_cat_dom. IPR001818. Pept_M10_metallopeptidase. IPR016293. Pept_M10A_matrix_strom. IPR021190. Pept_M10A_matrixin. IPR021158. Pept_M10A_Zn_BS. IPR006026. Peptidase_Metallo. IPR002477. Peptidoglycan-bd-like. [Graphical view]
Gene3D	G3DSA:3.40.390.10. G3DSA:3.40.390.10. 1 hit. G3DSA:2.110.10.10. Hemopexin. 1 hit.
KO	K01388.
Pfam	PF00045. Hemopexin. 4 hits. PF00413. Peptidase_M10. 1 hit. PF01471. PG_binding_1. 1 hit. [Graphical view]
PIRSF	PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTS	PR00138. MATRIXIN.
SMART	SM00120. HX. 4 hits. SM00235. ZnMc. 1 hit. [Graphical view]
SUPFAM	SSF50923. Hemopexin. 1 hit. SSF47090. PGBD_like. 1 hit.
PROSITE	PS00546. CYSTEINE_SWITCH. 1 hit. PS00024. HEMOPEXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4DN15_HUMAN

Accession

Primary (citable) accession number: B4DN15

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.