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Protein
Submitted name:

cDNA FLJ55228, highly similar to Interstitial collagenase (EC 3.4.24.7)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseSAAS annotation, Protease
LigandCalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ55228, highly similar to Interstitial collagenase (EC 3.4.24.7)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30867.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiB4DN15.
PeptideAtlasiB4DN15.
PRIDEiB4DN15.

Expressioni

Gene expression databases

GenevisibleiB4DN15. HS.

Structurei

3D structure databases

ProteinModelPortaliB4DN15.
SMRiB4DN15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 196ZnMcInterPro annotationAdd BLAST158
Repeati209 – 258HemopexinPROSITE-ProRule annotationAdd BLAST50
Repeati259 – 305HemopexinPROSITE-ProRule annotationAdd BLAST47
Repeati308 – 356HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati357 – 400HemopexinPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation

Keywords - Domaini

CollagenImported, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOVERGENiHBG052484.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR000585. Hemopexin-like_dom.
IPR036375. Hemopexin-like_dom_sf.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom_sf.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
IPR036365. PGBD-like_sf.
PfamiView protein in Pfam
PF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.

Sequencei

Sequence statusi: Complete.

B4DN15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEFFGLKVT GKPDAETLKV MKQPRCGVPD VAQFVLTEGN PRWEQTHLTY
60 70 80 90 100
RIENYTPDLP RADVDHAIEK AFQLWSNVTP LTFTKVSEGQ ADIMISFVRG
110 120 130 140 150
DHRDNSPFDG PGGNLAHAFQ PGPGIGGDAH FDEDERWTNN FREYNLHRVA
160 170 180 190 200
AHELGHSLGL SHSTDIGALM YPSYTFSGDV QLAQDDIDGI QAIYGRSQNP
210 220 230 240 250
VQPIGPQTPK ACDSKLTFDA ITTIRGEVMF FKDRFYMRTN PFYPEVELNF
260 270 280 290 300
ISVFWPQLPN GLEAAYEFAD RDEVRFFKGN KYWAVQGQNV LHGYPKDIYS
310 320 330 340 350
SFGFPRTVKH IDAALSEENT GKTYFFVANK YWRYDEYKRS MDPGYPKMIA
360 370 380 390 400
HDFPGIGHKV DAVFMKDGFF YFFHGTRQYK FDPKTKRILT LQKANSWFNC

RKN
Length:403
Mass (Da):46,266
Last modified:September 23, 2008 - v1
Checksum:i1004B620F5E64475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297723 mRNA. Translation: BAG60077.1.
RefSeqiNP_001139410.1. NM_001145938.1.
UniGeneiHs.83169.

Genome annotation databases

GeneIDi4312.

Similar proteinsi

Entry informationi

Entry nameiB4DN15_HUMAN
AccessioniPrimary (citable) accession number: B4DN15
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 22, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.