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B4DME2

- B4DME2_HUMAN

UniProt

B4DME2 - B4DME2_HUMAN

Protein
Submitted name:

Protein phosphatase 1 regulatory subunit 12C

Gene

PPP1R12C

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein phosphatase 1 regulatory subunit 12CImported
    Submitted name:
    cDNA FLJ59720, highly similar to Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 12C (PPP1R12C), mRNAImported
    Gene namesi
    Name:PPP1R12CImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:14947. PPP1R12C.

    Structurei

    3D structure databases

    SMRiB4DME2. Positions 18-241, 453-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 4 ANK repeats.UniRule annotation

    Keywords - Domaini

    ANK repeatUniRule annotation, RepeatUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000290648.
    HOVERGENiHBG104929.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4DME2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNGGPCQPL AAGPRAEGAS VNWSVTAWGP GTQACIDENL EVVRFLVEQG    50
    ATVNQADNEG WTPLHVAASC GYLDIARYLL SHGANIAAVN SDGDLPLDLA 100
    ESDAMEGLLK AEIARRGVDV EAAKRAEEEL LLHDTRCWLN GGAMPEARHP 150
    RTGASALHVA AAKGYIEVMR LLLQAGYDPE LRDGDGWTPL HAAAHWGVED 200
    ACRLLAEHGG GMDSLTHAGQ RPCDLADEEV LSLLEELARK QEDLRNQKEA 250
    SQSRGQEPQA PSSSKHRRSS VCRLSSREKI SLQDLSKERR PGGAGGPPIQ 300
    DEDEGEEGPT EPPPAEPRTL NGVSSPPHPS PKSPVQLEEA PFSRRFGLLK 350
    TGSSGALGPP ERRTAEGAPG AGLQRSASSS WLEGTSTQAK ELRLARITPT 400
    PSPKLPEPSV LSEVTKPPPC LENSSPPSRI PEPESPAKPN VPTASTAPPA 450
    DSRDRRRSYQ MPVRDEESES QRKARSRLMR QSRRSTQGVT LTDLKEAEKA 500
    AGKAPESEKP AQSLDPSRRP RVPGVENSDS PAQREAPDGQ GPGPQAAREH 550
    RKVGKEWRGP AEGEEAEPAD RSQESSTLEG GPSARRQRWQ RDLNPEPEPE 600
    SEEPDGGFRT LYAELRRENE RLREALTETT LRLAQLKVEL ERATQRQERF 650
    AERPALLELE RFERRALERK AAELEEELKA LSDLRADNQR LKDENAALIR 700
    VISKLSK 707
    Length:707
    Mass (Da):77,169
    Last modified:September 23, 2008 - v1
    Checksum:i991C11608AB2807F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005782 Genomic DNA. No translation available.
    AC010327 Genomic DNA. No translation available.
    AK297426 mRNA. Translation: BAG59854.1.
    UniGeneiHs.631579.

    Genome annotation databases

    EnsembliENST00000435544; ENSP00000387833; ENSG00000125503.
    UCSCiuc010yfs.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005782 Genomic DNA. No translation available.
    AC010327 Genomic DNA. No translation available.
    AK297426 mRNA. Translation: BAG59854.1 .
    UniGenei Hs.631579.

    3D structure databases

    SMRi B4DME2. Positions 18-241, 453-504.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000435544 ; ENSP00000387833 ; ENSG00000125503 .
    UCSCi uc010yfs.2. human.

    Organism-specific databases

    HGNCi HGNC:14947. PPP1R12C.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000290648.
    HOVERGENi HBG104929.

    Miscellaneous databases

    NextBioi 35473299.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB4DME2_HUMAN
    AccessioniPrimary (citable) accession number: B4DME2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3