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B4DME2 (B4DME2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

cDNA FLJ59720, highly similar to Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 12C (PPP1R12C), mRNA EMBL BAG59854.1
Gene names
Name:PPP1R12C Ensembl ENSP00000387833
OrganismHomo sapiens (Human) [Reference proteome] EMBL BAG59854.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 4 ANK repeats. RuleBase RU003321

Ontologies

Keywords
   DomainANK repeat RuleBase RU003321
Repeat RuleBase RU003536
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequences

Sequence LengthMass (Da)Tools
B4DME2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 991C11608AB2807F

FASTA70777,169
        10         20         30         40         50         60 
MRNGGPCQPL AAGPRAEGAS VNWSVTAWGP GTQACIDENL EVVRFLVEQG ATVNQADNEG 

        70         80         90        100        110        120 
WTPLHVAASC GYLDIARYLL SHGANIAAVN SDGDLPLDLA ESDAMEGLLK AEIARRGVDV 

       130        140        150        160        170        180 
EAAKRAEEEL LLHDTRCWLN GGAMPEARHP RTGASALHVA AAKGYIEVMR LLLQAGYDPE 

       190        200        210        220        230        240 
LRDGDGWTPL HAAAHWGVED ACRLLAEHGG GMDSLTHAGQ RPCDLADEEV LSLLEELARK 

       250        260        270        280        290        300 
QEDLRNQKEA SQSRGQEPQA PSSSKHRRSS VCRLSSREKI SLQDLSKERR PGGAGGPPIQ 

       310        320        330        340        350        360 
DEDEGEEGPT EPPPAEPRTL NGVSSPPHPS PKSPVQLEEA PFSRRFGLLK TGSSGALGPP 

       370        380        390        400        410        420 
ERRTAEGAPG AGLQRSASSS WLEGTSTQAK ELRLARITPT PSPKLPEPSV LSEVTKPPPC 

       430        440        450        460        470        480 
LENSSPPSRI PEPESPAKPN VPTASTAPPA DSRDRRRSYQ MPVRDEESES QRKARSRLMR 

       490        500        510        520        530        540 
QSRRSTQGVT LTDLKEAEKA AGKAPESEKP AQSLDPSRRP RVPGVENSDS PAQREAPDGQ 

       550        560        570        580        590        600 
GPGPQAAREH RKVGKEWRGP AEGEEAEPAD RSQESSTLEG GPSARRQRWQ RDLNPEPEPE 

       610        620        630        640        650        660 
SEEPDGGFRT LYAELRRENE RLREALTETT LRLAQLKVEL ERATQRQERF AERPALLELE 

       670        680        690        700 
RFERRALERK AAELEEELKA LSDLRADNQR LKDENAALIR VISKLSK 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R., Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[3]"NEDO human cDNA sequencing project focused on splicing variants."
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. expand/collapse author list , Sugano S., Nomura N., Isogai T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain EMBL BAG59854.1.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005782 Genomic DNA. No translation available.
AC010327 Genomic DNA. No translation available.
AK297426 mRNA. Translation: BAG59854.1.
UniGeneHs.631579.

3D structure databases

ProteinModelPortalB4DME2.
SMRB4DME2. Positions 18-241, 453-504.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000435544; ENSP00000387833; ENSG00000125503.
KEGGhsa:54776.
UCSCuc010yfs.2. human.

Organism-specific databases

HGNCHGNC:14947. PPP1R12C.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000290648.
HOVERGENHBG104929.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi54776.
NextBio35473299.

Entry information

Entry nameB4DME2_HUMAN
AccessionPrimary (citable) accession number: B4DME2
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.