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B4DMC9

- B4DMC9_HUMAN

UniProt

B4DMC9 - B4DMC9_HUMAN

Protein
Submitted name:

cDNA FLJ50990, highly similar to Gap junction alpha-1 protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: Ensembl
    2. ATP transport Source: Ensembl
    3. cell-cell signaling Source: Ensembl
    4. cellular response to mechanical stimulus Source: Ensembl
    5. chronic inflammatory response Source: Ensembl
    6. endothelium development Source: Ensembl
    7. heart development Source: Ensembl
    8. negative regulation of cardiac muscle cell proliferation Source: Ensembl
    9. neuron projection morphogenesis Source: Ensembl
    10. positive regulation of behavioral fear response Source: Ensembl
    11. positive regulation of cell communication by chemical coupling Source: Ensembl
    12. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    13. positive regulation of glomerular filtration Source: Ensembl
    14. positive regulation of protein catabolic process Source: Ensembl
    15. positive regulation of vasoconstriction Source: Ensembl
    16. positive regulation of vasodilation Source: Ensembl
    17. protein oligomerization Source: Ensembl
    18. regulation of calcium ion transport Source: Ensembl
    19. regulation of tight junction assembly Source: Ensembl
    20. response to fluid shear stress Source: Ensembl
    21. response to peptide hormone Source: Ensembl
    22. response to pH Source: Ensembl
    23. vascular transport Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA FLJ50990, highly similar to Gap junction alpha-1 proteinImported
    Submitted name:
    cDNA, FLJ79058, highly similar to Gap junction alpha-1 proteinImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation. Cell junctiongap junction SAAS annotation

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. early endosome Source: Ensembl
    3. fascia adherens Source: Ensembl
    4. Golgi apparatus Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. lysosome Source: Ensembl
    7. membrane raft Source: Ensembl
    8. mitochondrial outer membrane Source: Ensembl
    9. multivesicular body Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membraneSAAS annotation, Gap junctionSAAS annotation, Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiB4DMC9.
    BgeeiB4DMC9.

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG009576.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002261. Connexin43.
    IPR013124. Connexin43_C.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF03508. Connexin43. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01132. CONNEXINA1.
    SMARTiSM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4DMC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKEEKLNKK EEELKVAQTD GVNVDMHLKQ IEIKKFKYGI EEHGKVKMRG    50
    GLLRTYIISI LFKSIFEVAF LLIQWYIYGF SLSAVYTCKR DPCPHQVDCF 100
    LSRPTEKTIF IIFMLVVSLV SLALNIIELF YVFFKGVKDR VKGKSDPYHA 150
    TSGALSPAKD CGSQKYAYFN GCSSPTAPLS PMSPPGYKLV TGDRNNSSCR 200
    NYNKQASEQN WANYSAEQNR MGQAGSTISN SHAQPFDFPD DNQNSKKLAA 250
    GHELQPLAIV DQRPSSRASS RASSRPRPDD LEI 283
    Length:283
    Mass (Da):31,864
    Last modified:September 23, 2008 - v1
    Checksum:i6C4B79EE24F63AA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK297402 mRNA. Translation: BAG59841.1.
    AK316159 mRNA. Translation: BAH14530.1.

    Genome annotation databases

    UCSCiuc011ebp.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK297402 mRNA. Translation: BAG59841.1 .
    AK316159 mRNA. Translation: BAH14530.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc011ebp.1. human.

    Phylogenomic databases

    HOVERGENi HBG009576.

    Miscellaneous databases

    NextBioi 35473288.

    Gene expression databases

    ArrayExpressi B4DMC9.
    Bgeei B4DMC9.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002261. Connexin43.
    IPR013124. Connexin43_C.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF03508. Connexin43. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01132. CONNEXINA1.
    SMARTi SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiB4DMC9_HUMAN
    AccessioniPrimary (citable) accession number: B4DMC9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.