Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Prolyl endopeptidase FAP

Gene

FAP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Protein family/group databases

ESTHERihuman-FAP DPP4N_Peptidase_S9

Names & Taxonomyi

Protein namesi
Submitted name:
Prolyl endopeptidase FAPImported
Submitted name:
cDNA FLJ60298, highly similar to Seprase (EC 3.4.21.-)Imported
Gene namesi
Name:FAPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000078098.13
HGNCiHGNC:3590 FAP

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078098

PTM / Processingi

Proteomic databases

PeptideAtlasiB4DLR2
PRIDEiB4DLR2

Expressioni

Gene expression databases

BgeeiENSG00000078098
ExpressionAtlasiB4DLR2 baseline and differential

Structurei

3D structure databases

SMRiB4DLR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 447DPPIV_NInterPro annotationAdd BLAST362
Domaini530 – 732Peptidase_S9InterPro annotationAdd BLAST203

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili455 – 475Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase S9B family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
GeneTreeiENSGT00760000119233
HOGENOMiHOG000231875
HOVERGENiHBG005527

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR031245 FAP/Dpf2
IPR002471 Pept_S9_AS
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PANTHERiPTHR11731:SF136 PTHR11731:SF136, 2 hits
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00708 PRO_ENDOPEP_SER, 1 hit

Sequencei

Sequence statusi: Complete.

B4DLR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG
60 70 80 90 100
TFSYKTFFPN WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMLWRYS
110 120 130 140 150
YTATYYIYDL SNGEFVRGNE LPRPIQYLCW SPVGSKLAYV YQNNIYLKQR
160 170 180 190 200
PGDPPFQITF NGRENKIFNG IPDWVYEEEM LATKYALWWS PNGKFLAYAE
210 220 230 240 250
FNDTDIPVIA YSYYGDEQYP RTINIPYPKA GAKNPVVRIF IIDTTYPAYV
260 270 280 290 300
GPQEVPVPAM IASSDYYFSW LTWVTDERVC LQWLKRVQNV SVLSICDFRE
310 320 330 340 350
DWQTWDCPKT QEHIEESRTG WAGGFFVSTP VFSYDAISYY KIFSDKDGYK
360 370 380 390 400
HIHYIKDTVE NAIQITSGKW EAINIFRVTQ DSLFYSSNEF EEYPGRRNIY
410 420 430 440 450
RISIGSYPPS KKCVTCHLRK ERCQYYTASF SDYAKYYALV CYGPGIPIST
460 470 480 490 500
LHDGRTDQEI KILEENKELE NALKNIQLPK EEIKKLEVDE ITLWYKMILP
510 520 530 540 550
PQFDRSKKYP LLIQVYGGPC SQSVRSVFAV NWISYLASKE GMVIALVDGR
560 570 580 590 600
GTAFQGDKLL YAVYRKLGVY EVEDQITAVR KFIEMGFIDE KRIAIWGWSY
610 620 630 640 650
GGYVSSLALA SGTGLFKCGI AVAPVSSWEY YASVYTERFM GLPTKDDNLE
660 670 680 690 700
HYKNSTVMAR AEYFRNVDYL LIHGTADDNV HFQNSAQIAK ALVNAQVDFQ
710 720 730
AMWYSDQNHG LSGLSTNHLY THMTHFLKQC FSLSD
Length:735
Mass (Da):84,862
Last modified:September 23, 2008 - v1
Checksum:iA6ABE4083721544D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007750 Genomic DNA No translation available.
AK297118 mRNA Translation: BAG59624.1
RefSeqiNP_001278736.1, NM_001291807.2
UniGeneiHs.654370

Genome annotation databases

EnsembliENST00000443424; ENSP00000411391; ENSG00000078098
GeneIDi2191
UCSCiuc010zct.3 human

Similar proteinsi

Entry informationi

Entry nameiB4DLR2_HUMAN
AccessioniPrimary (citable) accession number: B4DLR2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health