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Protein
Submitted name:

SH2B adapter protein 1

Gene

SH2B1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
SH2B adapter protein 1Imported
Submitted name:
cDNA FLJ59336, highly similar to Homo sapiens SH2-B homolog (SH2B), mRNAImported
Gene namesi
Name:SH2B1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:30417. SH2B1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148084.

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains PH domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063355.
HOGENOMiHOG000047355.
HOVERGENiHBG103068.
KOiK12459.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR001849. PH_domain.
IPR000980. SH2.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DLN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRENTFVV KVEGPSEYIM ETVDAQHVKA WVSDIQECLS PGPCPATSPR
60 70 80 90 100
PMTLPLAPGT SFLTRENTDS LELSCLNHSE SLPSQDLLLG PSESNDRLSQ
110 120 130 140 150
GAYGGLSDRP SASISPSSAS IAASHFDSME LLPPELPPRI PIEEGPPTGT
160 170 180 190 200
VHPLSAPYPP LDTPETATGS FLFQGEPEGG EGDQPLSGYP WFHGMLSRLK
210 220 230 240 250
AAQLVLTGGT GSHGVFLVRQ SETRRGEYVL TFNFQGKAKH LRLSLNEEGQ
260 270 280 290 300
CRVQHLWFQS IFDMLEHFRV HPIPLESGGS SDVVLVSYVP SSQRQQGREQ
310 320 330
AGSHAGVCEG DGCHPDASCT LMPFGASDCV TDHLP
Length:335
Mass (Da):36,098
Last modified:September 23, 2008 - v1
Checksum:iDFFC08365A14A272
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133550 Genomic DNA. No translation available.
AK297080 mRNA. Translation: BAG59597.1.
RefSeqiNP_001139267.1. NM_001145795.1.
NP_001139268.1. NM_001145796.1.
NP_001139269.1. NM_001145797.1.
XP_005255297.1. XM_005255240.1.
UniGeneiHs.15744.

Genome annotation databases

EnsembliENST00000538342; ENSP00000438784; ENSG00000178188.
GeneIDi25970.
KEGGihsa:25970.
UCSCiuc010vdd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133550 Genomic DNA. No translation available.
AK297080 mRNA. Translation: BAG59597.1.
RefSeqiNP_001139267.1. NM_001145795.1.
NP_001139268.1. NM_001145796.1.
NP_001139269.1. NM_001145797.1.
XP_005255297.1. XM_005255240.1.
UniGeneiHs.15744.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000538342; ENSP00000438784; ENSG00000178188.
GeneIDi25970.
KEGGihsa:25970.
UCSCiuc010vdd.2. human.

Organism-specific databases

CTDi25970.
HGNCiHGNC:30417. SH2B1.
PharmGKBiPA145148084.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063355.
HOGENOMiHOG000047355.
HOVERGENiHBG103068.
KOiK12459.

Miscellaneous databases

GenomeRNAii25970.
NextBioi47602.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR001849. PH_domain.
IPR000980. SH2.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Cord bloodImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB4DLN5_HUMAN
AccessioniPrimary (citable) accession number: B4DLN5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.