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Protein
Submitted name:

SH2B adapter protein 1

Gene

SH2B1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
SH2B adapter protein 1Imported
Submitted name:
cDNA FLJ59336, highly similar to Homo sapiens SH2-B homolog (SH2B), mRNAImported
Gene namesi
Name:SH2B1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000178188.14
HGNCiHGNC:30417 SH2B1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178188
PharmGKBiPA145148084

PTM / Processingi

Proteomic databases

MaxQBiB4DLN5
PeptideAtlasiB4DLN5
PRIDEiB4DLN5

Expressioni

Gene expression databases

BgeeiENSG00000178188
ExpressionAtlasiB4DLN5 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 40PHInterPro annotationAdd BLAST40
Domaini191 – 289SH2InterPro annotationAdd BLAST99

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IMWK Eukaryota
ENOG41102PH LUCA
GeneTreeiENSGT00530000063355
HOGENOMiHOG000047355
HOVERGENiHBG103068
KOiK12459

Family and domain databases

CDDicd10346 SH2_SH2B_family, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR030523 SH2B
IPR030521 SH2B1
IPR035057 SH2B1_SH2
PANTHERiPTHR10872 PTHR10872, 1 hit
PTHR10872:SF3 PTHR10872:SF3, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

B4DLN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRENTFVV KVEGPSEYIM ETVDAQHVKA WVSDIQECLS PGPCPATSPR
60 70 80 90 100
PMTLPLAPGT SFLTRENTDS LELSCLNHSE SLPSQDLLLG PSESNDRLSQ
110 120 130 140 150
GAYGGLSDRP SASISPSSAS IAASHFDSME LLPPELPPRI PIEEGPPTGT
160 170 180 190 200
VHPLSAPYPP LDTPETATGS FLFQGEPEGG EGDQPLSGYP WFHGMLSRLK
210 220 230 240 250
AAQLVLTGGT GSHGVFLVRQ SETRRGEYVL TFNFQGKAKH LRLSLNEEGQ
260 270 280 290 300
CRVQHLWFQS IFDMLEHFRV HPIPLESGGS SDVVLVSYVP SSQRQQGREQ
310 320 330
AGSHAGVCEG DGCHPDASCT LMPFGASDCV TDHLP
Length:335
Mass (Da):36,098
Last modified:September 23, 2008 - v1
Checksum:iDFFC08365A14A272
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133550 Genomic DNA No translation available.
AK297080 mRNA Translation: BAG59597.1
RefSeqiNP_001139267.1, NM_001145795.1
NP_001139268.1, NM_001145796.1
NP_001139269.1, NM_001145797.1
NP_001295223.1, NM_001308294.1
UniGeneiHs.15744

Genome annotation databases

EnsembliENST00000538342; ENSP00000438784; ENSG00000178188
GeneIDi25970
KEGGihsa:25970
UCSCiuc010vdd.3 human

Similar proteinsi

Entry informationi

Entry nameiB4DLN5_HUMAN
AccessioniPrimary (citable) accession number: B4DLN5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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