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Protein

DNA helicase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase

Keywords - Biological processi

DNA replicationSAAS annotation

Keywords - Ligandi

ATP-binding, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiB4DLA6.
PeptideAtlasiB4DLA6.
PRIDEiB4DLA6.

Expressioni

Gene expression databases

GenevisibleiB4DLA6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262105.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini418 – 626209MCMInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MCM family.UniRule annotationSAAS annotation
Contains MCM domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0478. Eukaryota.
COG1241. LUCA.
HOGENOMiHOG000224127.
HOVERGENiHBG102781.
KOiK02212.

Family and domain databases

Gene3Di2.20.28.10. 1 hit.
2.40.50.140. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR031327. MCM.
IPR008047. MCM_4.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR004039. Rubredoxin-type_fold.
[Graphical view]
PfamiPF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
PR01660. MCMPROTEIN4.
SMARTiSM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DLA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGHLPLRDV EARIPPPRGS CSRCQPRLEW TCRALLRRTC CFPALPKCIL
60 70 80 90 100
QLSLLTLMLE GTPRSGVRGT PVRQRPDLGS AQKGLQVDLQ SDGAAAEDIV
110 120 130 140 150
ASEQSLGQKL VIWGTDVNVA ACKENFQRFL QRFIDPLAKE EENVGIDITE
160 170 180 190 200
PLYMQRLGEI NVIGEPFLNV NCEHIKSFDK NLYRQLISYP QEVIPTFDMA
210 220 230 240 250
VNEIFFDRYP DSILEHQIQV RPFNALKTKN MRNLNPEDID QLITISGMVI
260 270 280 290 300
RTSQLIPEMQ EAFFQCQVCA HTTRVEMDRG RIAEPSVCGR CHTTHSMALI
310 320 330 340 350
HNRSLFSDKQ MIKLQESPED MPAGQTPHTV ILFAHNDLVD KVQPGDRVNV
360 370 380 390 400
TGIYRAVPIR VNPRVSNVKS VYKTHIDVIH YRKTDAKRLH GLDEEAEQKL
410 420 430 440 450
FSEKRVELLK ELSRKPDIYE RLASALAPSI YEHEDIKKGI LLQLFGGTRK
460 470 480 490 500
DFSHTGGGKF RAEINILLCG DPGTSKSQLL QYVYNLVPRG QYTSGKGSSA
510 520 530 540 550
VGLTAYVMKD PETRQLVLQT GALVLSDNGI CCIDEFDKMN ESTRSVLHEV
560 570 580 590 600
MEQQTLSIAK AGIICQLNAR TSVLAAANPI ESQWNPKKTT IENIQLPHTL
610 620 630 640 650
LSRFDLIFLM LDPQDEAYDR RLAHHLVALY YQSEEQAEEE LLDMAVLKDY
660 670 680 690 700
IAYAHSTIMP RLSEEASQAL IEAYVDMRKI GSSRGMVSAY PRQLESLIRL
710 720 730 740 750
AEAHAKVRLS NKVEAIDVEE AKRLHREALK QSATDPRTGI VDISILTTGM
760 770 780 790 800
SATSRKRKEE LAEALKKLIL SKGKTPALKY QQLFEDIRGQ SDIAITKDMF
810 820
EEALRALADD DFLTVTGKTV RLL
Length:823
Mass (Da):92,723
Last modified:September 23, 2008 - v1
Checksum:i85FE1F8514B88675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296913 mRNA. Translation: BAG59468.1.
RefSeqiNP_005905.2. NM_005914.3.
UniGeneiHs.460184.

Genome annotation databases

GeneIDi4173.
KEGGihsa:4173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296913 mRNA. Translation: BAG59468.1.
RefSeqiNP_005905.2. NM_005914.3.
UniGeneiHs.460184.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262105.

Proteomic databases

PaxDbiB4DLA6.
PeptideAtlasiB4DLA6.
PRIDEiB4DLA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4173.
KEGGihsa:4173.

Organism-specific databases

CTDi4173.

Phylogenomic databases

eggNOGiKOG0478. Eukaryota.
COG1241. LUCA.
HOGENOMiHOG000224127.
HOVERGENiHBG102781.
KOiK02212.

Miscellaneous databases

GenomeRNAii4173.

Gene expression databases

GenevisibleiB4DLA6. HS.

Family and domain databases

Gene3Di2.20.28.10. 1 hit.
2.40.50.140. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR031327. MCM.
IPR008047. MCM_4.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR004039. Rubredoxin-type_fold.
[Graphical view]
PfamiPF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
PR01660. MCMPROTEIN4.
SMARTiSM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TongueImported.

Entry informationi

Entry nameiB4DLA6_HUMAN
AccessioniPrimary (citable) accession number: B4DLA6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 6, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.