B4DKQ2 (B4DKQ2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
L-lactate dehydrogenase RuleBase RU000496
EC=1.1.1.27 RuleBase RU000496

Gene names

Name:

LDHA Ensembl ENSP00000406172

Organism

Homo sapiens (Human) EMBL BAG59264.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(S)-lactate + NAD+ = pyruvate + NADH. RuleBase RU000496
Pathway	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. RuleBase RU000496
Sequence similarities	Belongs to the LDH/MDH superfamily. LDH family. RuleBase RU004149

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU000496
Ligand	NAD RuleBase RU000496
Molecular function	Oxidoreductase RuleBase RU000496
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-lactate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4DKQ2 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 1EB83D11978134AD	FASTA	274	30,205
	10 20 30 40 50 60 MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG 70 80 90 100 110 120 EMMDLQHGSL FLRTPKIVSG KVDILTYVAW KISGFPKNRV IGSGCNLDSA RFRYLMGERL 130 140 150 160 170 180 GVHPLSCHGW VLGEHGDSSV PVWSGMNVAG VSLKTLHPDL GTDKDKEQWK EVHKQVVESA 190 200 210 220 230 240 YEVIKLKGYT SWAIGLSVAD LAESIMKNLR RVHPVSTMIK GLYGIKDDVF LSVPCILGQN 250 260 270 GISDLVKVTL TSEEEARLKK SADTLWGIQK ELQF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Cord blood EMBL BAG59264.1.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC084117 Genomic DNA. No translation available. AK296667 mRNA. Translation: BAG59264.1.
IPI	IPI00910754.
RefSeq	NP_001128711.1. NM_001135239.1.
UniGene	Hs.2795.
3D structure databases
ProteinModelPortal	B4DKQ2.
SMR	B4DKQ2. Positions 2-274.
ModBase	Search...
Protein-protein interaction databases
STRING	B4DKQ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000430553; ENSP00000406172; ENSG00000134333.
GeneID	3939.
KEGG	hsa:3939.
Organism-specific databases
CTD	3939.
HGNC	HGNC:6535. LDHA.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074541.
HOVERGEN	HBG000462.
Gene expression databases
Bgee	B4DKQ2.
Family and domain databases
InterPro	IPR001557. L-lactate/malate_DH. IPR018177. L-lactate_DH_AS. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KO	K00016.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
PROSITE	PS00064. L_LDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4DKQ2_HUMAN

Accession

Primary (citable) accession number: B4DKQ2

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.