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Protein

Citrate synthase

Gene

CS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthaseUniRule annotation
Gene namesi
Name:CSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000062485.18
HGNCiHGNC:2422 CS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000062485

Expressioni

Gene expression databases

BgeeiENSG00000062485

Interactioni

Protein-protein interaction databases

IntActiB4DJV2, 1 interactor

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UZQX-ray2.16A15-453[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2617 Eukaryota
COG0372 LUCA
GeneTreeiENSGT00390000006813
HOVERGENiHBG005336

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR010109 Citrate_synthase_euk
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01793 cit_synth_euk, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

B4DJV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASCLVLAA RHASASSTNL KDILADLIPK EQARIKTFRQ QHGKTVVGQI
60 70 80 90 100
TVDMMYGGMR GMKGLVYETS VLDPDEGIRF RGFSIPECQK LLPKAKGGEE
110 120 130 140 150
PLPEGLFWLL VTGHIPTEEQ VSWLSKEWAK RAALPSHVVT MLDNFPTNLH
160 170 180 190 200
PMSQLSAAVT ALNSESNFAR AYAQGISRTK YWELIYEDSM DLIAKLPCVA
210 220 230 240 250
AKIYRNLYRE GSGIGAIDSN LDWSHNFTNM LGYTDHQFTE LTRLYLTIHS
260 270 280 290 300
DHEGGNVSAH TSHLVGSALS DPYLSFAAAM NGLAGPLHGL ANQEVLVWLT
310 320 330 340 350
QLQKEVGKDV SDEKLRDYIW NTLNSGRVVP GYGHAVLRKT DPRYTCQREF
360 370 380 390 400
ALKHLPNDPM FKLVAQLYKI VPNVLLEQGK AKNPWPNVDA HSGVLLQYYG
410 420 430 440 450
MTEMNYYTVL FGVSRALGVL AQLIWSRALG FPLERPKSMS TEGLMKFVDS

KSG
Length:453
Mass (Da):50,432
Last modified:September 23, 2008 - v1
Checksum:i464FA128AF14EA4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073896 Genomic DNA No translation available.
AK296249 mRNA Translation: BAG58964.1
UniGeneiHs.743252

Genome annotation databases

EnsembliENST00000542324; ENSP00000440543; ENSG00000062485
UCSCiuc010sql.2 human

Similar proteinsi

Entry informationi

Entry nameiB4DJV2_HUMAN
AccessioniPrimary (citable) accession number: B4DJV2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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