cDNA FLJ58724, highly similar to Eukaryotic translation initiation factor2-alpha kinase 1 (EC 2.7.11.1)

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein kinase activity Source: InterPro
translation initiation factor activity Source: UniProtKB-KW

Keywordsⁱ

Molecular function	Initiation factorImported, KinaseImported, Transferase
Biological process	Protein biosynthesis

Enzyme and pathway databases

SignaLinkⁱ	B4DIP4.

SignaLinkⁱ

B4DIP4.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: cDNA FLJ58724, highly similar to Eukaryotic translation initiation factor2-alpha kinase 1 (EC 2.7.11.1)Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B4DIP4.
PaxDbⁱ	B4DIP4.
PeptideAtlas More...PeptideAtlasⁱ	B4DIP4.
PRIDEⁱ	B4DIP4.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000086232.

Bgeeⁱ

ENSG00000086232.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B4DIP4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	43 – 459	Protein kinaseInterPro annotationAdd BLAST		417

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	464 – 493	Sequence analysisAdd BLAST		30

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410ISBT. Eukaryota. ENOG410YD23. LUCA.
HOVERGENⁱ	HBG051429.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 2 hits.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B4DIP4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNQTHFVQDR CLSDPCEDIS RIQKIRSREV ALEAQTSRYL NEFEELAILG 
        60         70         80         90        100
KGGYGRVYKV RNKLDGQYYA IKKILIKGAT KTVCMKVLRE VKVLAGLQHP 
       110        120        130        140        150
NIVGYHTAWI EHVHVIQPRA DRAAIELPSL EVLSDQEEDR EQCGVKNDES 
       160        170        180        190        200
SSSSIIFAEP TPEKEKRFGE SDTENQNNKS VKYTTNLVIR ESGELESTLE 
       210        220        230        240        250
LQENGLAGLS ASSIVEQQLP LRRNSHLEES FTSTEESSEE NVNFLGQTEA 
       260        270        280        290        300
QYHLMLHIQM QLCELSLWDW IVERNKRGRE YVDESACPYV MANVATKIFQ 
       310        320        330        340        350
ELVEGVFYIH NMGIVHRDLK PRNIFLHGPD QQVKIGDFGL ACTDILQKNT 
       360        370        380        390        400
DWTNRNGKRT PTHTSRVGTC LYASPEQLEG SEYDAKSDMY SLGVVLLELF 
       410        420        430        440        450
QPFGTEMERA EVLTGLRTGQ LPESLRKRCP VQAKYIQHLT RRNSSQRPSA 
       460        470        480        490        500
IQLLQSELFQ NSGNVNLTLQ MKIIEQEKEI AELKKQLNLL SQDKGFSVIP 
       510        520        530        540        550
KPHPCKALYS APQMISRQLR SLSCLCPALF PGTSSFIVAL SSPANLYIPQ 
       560        570 
RQRSDELVFE SQKGSAMELA VITVDGV

Length:577

Mass (Da):65,280

Last modified:September 23, 2008 - v1

Checksum:ⁱ7AF34700412BD5EF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK295712 mRNA. Translation: BAG58556.1.
UniGeneⁱ	Hs.520205.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK295712 mRNA. Translation: BAG58556.1.
UniGeneⁱ	Hs.520205.

3D structure databases

ProteinModelPortalⁱ	B4DIP4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B4DIP4.
PaxDbⁱ	B4DIP4.
PeptideAtlas More...PeptideAtlasⁱ	B4DIP4.
PRIDEⁱ	B4DIP4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ISBT. Eukaryota. ENOG410YD23. LUCA.
HOVERGENⁱ	HBG051429.

Enzyme and pathway databases

SignaLinkⁱ	B4DIP4.

SignaLinkⁱ

B4DIP4.

Miscellaneous databases

ChiTaRSⁱ	EIF2AK1. human.

ChiTaRSⁱ

EIF2AK1. human.

Gene expression databases

Bgeeⁱ	ENSG00000086232.

Bgeeⁱ

ENSG00000086232.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 2 hits.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B4DIP4_HUMAN
Accessionⁱ	B4DIP4Primary (citable) accession number: B4DIP4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 23, 2008
	Last sequence update:	September 23, 2008
	Last modified:	July 5, 2017
	This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - B4DIP4 (B4DIP4_HUMAN)

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cDNA FLJ58724, highly similar to Eukaryotic translation initiation factor2-alpha kinase 1 (EC 2.7.11.1)

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B4DIP4 (B4DIP4_HUMAN)

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cDNA FLJ58724, highly similar to Eukaryotic translation initiation factor2-alpha kinase 1 (EC 2.7.11.1)

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ