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Protein
Submitted name:

cDNA FLJ58724, highly similar to Eukaryotic translation initiation factor2-alpha kinase 1 (EC 2.7.11.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factorImported, Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB4DIP4.

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ58724, highly similar to Eukaryotic translation initiation factor2-alpha kinase 1 (EC 2.7.11.1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

EPDiB4DIP4.
PaxDbiB4DIP4.
PRIDEiB4DIP4.

Expressioni

Gene expression databases

BgeeiB4DIP4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000199389.

Structurei

3D structure databases

ProteinModelPortaliB4DIP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 459417Protein kinaseInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili464 – 49330Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410ISBT. Eukaryota.
ENOG410YD23. LUCA.
HOVERGENiHBG051429.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DIP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTHFVQDR CLSDPCEDIS RIQKIRSREV ALEAQTSRYL NEFEELAILG
60 70 80 90 100
KGGYGRVYKV RNKLDGQYYA IKKILIKGAT KTVCMKVLRE VKVLAGLQHP
110 120 130 140 150
NIVGYHTAWI EHVHVIQPRA DRAAIELPSL EVLSDQEEDR EQCGVKNDES
160 170 180 190 200
SSSSIIFAEP TPEKEKRFGE SDTENQNNKS VKYTTNLVIR ESGELESTLE
210 220 230 240 250
LQENGLAGLS ASSIVEQQLP LRRNSHLEES FTSTEESSEE NVNFLGQTEA
260 270 280 290 300
QYHLMLHIQM QLCELSLWDW IVERNKRGRE YVDESACPYV MANVATKIFQ
310 320 330 340 350
ELVEGVFYIH NMGIVHRDLK PRNIFLHGPD QQVKIGDFGL ACTDILQKNT
360 370 380 390 400
DWTNRNGKRT PTHTSRVGTC LYASPEQLEG SEYDAKSDMY SLGVVLLELF
410 420 430 440 450
QPFGTEMERA EVLTGLRTGQ LPESLRKRCP VQAKYIQHLT RRNSSQRPSA
460 470 480 490 500
IQLLQSELFQ NSGNVNLTLQ MKIIEQEKEI AELKKQLNLL SQDKGFSVIP
510 520 530 540 550
KPHPCKALYS APQMISRQLR SLSCLCPALF PGTSSFIVAL SSPANLYIPQ
560 570
RQRSDELVFE SQKGSAMELA VITVDGV
Length:577
Mass (Da):65,280
Last modified:September 23, 2008 - v1
Checksum:i7AF34700412BD5EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295712 mRNA. Translation: BAG58556.1.
UniGeneiHs.520205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295712 mRNA. Translation: BAG58556.1.
UniGeneiHs.520205.

3D structure databases

ProteinModelPortaliB4DIP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000199389.

Proteomic databases

EPDiB4DIP4.
PaxDbiB4DIP4.
PRIDEiB4DIP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410ISBT. Eukaryota.
ENOG410YD23. LUCA.
HOVERGENiHBG051429.

Enzyme and pathway databases

SignaLinkiB4DIP4.

Miscellaneous databases

ChiTaRSiEIF2AK1. human.
NextBioi35472325.

Gene expression databases

BgeeiB4DIP4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.

Entry informationi

Entry nameiB4DIP4_HUMAN
AccessioniPrimary (citable) accession number: B4DIP4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.