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Protein
Submitted name:

Protein LAP2

Gene

ERBIN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein LAP2Imported
Submitted name:
cDNA FLJ58745, highly similar to Protein LAP2Imported
Gene namesi
Name:ERBINImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:15842. ERBIN.

Expressioni

Gene expression databases

ExpressionAtlasiB4DIP2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370330.

Structurei

3D structure databases

SMRiB4DIP2. Positions 19-445, 481-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini519 – 60890PDZ (DHR)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG410KCZ0. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000069964.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR032927. LAP2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23155:SF421. PTHR23155:SF421. 1 hit.
PfamiPF13855. LRR_8. 4 hits.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 14 hits.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DIP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE
60 70 80 90 100
LYLDANQIEE LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS
110 120 130 140 150
KNGIQEFPEN IKNCKVLTIV EASVNPISKL PDGFSQLLNL TQLYLNDAFL
160 170 180 190 200
EFLPANFGRL TKLQILELRE NQLKMLPKTM NRLTQLERLD LGSNEFTEVP
210 220 230 240 250
EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN NIEMVEEGIS
260 270 280 290 300
TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS
310 320 330 340 350
VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL
360 370 380 390 400
FLHSNKLETL PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD
410 420 430 440 450
NQSMLSRSFN SNFTTVSSFH CGSSRDLHGS QGSLALSVAD RRGSGGHIFR
460 470 480 490 500
MPLSNGQMGQ PLRPQANYSQ IHHPPQASVA RHPSREQLID YLMLKVAHQP
510 520 530 540 550
PYTQPHCSPR QGHELAKQEI RVRVEKDPEL GFSISGGVGG RGNPFRPDDD
560 570 580 590 600
GIFVTRVQPE GPASKLLQPG DKIIQANGYS FINIEHGQAV SLLKTFQNTV
610
ELIIVREVSS
Length:610
Mass (Da):68,569
Last modified:September 23, 2008 - v1
Checksum:iEC06312F0E85C798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010359 Genomic DNA. No translation available.
AC025442 Genomic DNA. No translation available.
AK295708 mRNA. Translation: BAG58554.1.
UniGeneiHs.591774.
Hs.597241.

Genome annotation databases

EnsembliENST00000416865; ENSP00000397833; ENSG00000112851.
UCSCiuc011cqz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010359 Genomic DNA. No translation available.
AC025442 Genomic DNA. No translation available.
AK295708 mRNA. Translation: BAG58554.1.
UniGeneiHs.591774.
Hs.597241.

3D structure databases

SMRiB4DIP2. Positions 19-445, 481-610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416865; ENSP00000397833; ENSG00000112851.
UCSCiuc011cqz.3. human.

Organism-specific databases

HGNCiHGNC:15842. ERBIN.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCZ0. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000069964.

Miscellaneous databases

ChiTaRSiERBB2IP. human.
NextBioi35472324.

Gene expression databases

ExpressionAtlasiB4DIP2. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR032927. LAP2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23155:SF421. PTHR23155:SF421. 1 hit.
PfamiPF13855. LRR_8. 4 hits.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 14 hits.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  5. "N-terminome analysis of the human mitochondrial proteome."
    Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.
    Proteomics 15:2519-2524(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiB4DIP2_HUMAN
AccessioniPrimary (citable) accession number: B4DIP2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.