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Protein
Submitted name:

cDNA FLJ50741, highly similar to Glutamate (NMDA) receptor subunit epsilon 1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: InterPro
  2. ionotropic glutamate receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ50741, highly similar to Glutamate (NMDA) receptor subunit epsilon 1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28979.

PTM / Processingi

Proteomic databases

PRIDEiB4DII7.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG052635.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DII7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIMQDYDW HVFSLVTTIF PGYREFISFV KTTVDNSFVG WDMQNVITLD
60 70 80 90 100
TSFEDAKTQV QLKKIHSSVI LLYCSKDEAV LILSEARSLG LTGYDFFWIV
110 120 130 140 150
PSLVSGNTEL IPKEFPSGLI SVSYDDWDYS LEARVRDGIG ILTTAASSML
160 170 180 190 200
EKFSYIPEAK ASCYGQMERP EVPMHTLHPF MVNVTWDGKD LSFTEEGYQV
210 220 230 240 250
HPRLVVIVLN KDREWEKVGK WENHTLSLRH AVWPRYKSFS DCEPDDNHLS
260 270 280 290 300
IVTLEEAPFV IVEDIDPLTE TCVRNTVPCR KFVKINNSTN EGMNVKKCCK
310 320 330 340 350
GFCIDILKKL SRTVKFTYDL YLVTNGKHGK KVNNVWNGMI GEVVYQRAVM
360 370 380 390 400
AVGSLTINEE RSEVVDFSVP FVETGISVMV SRSNGTVSPS AFLEPFSASV
410 420 430 440 450
WVMMFVMLLI VSAIAVFVFE YFSPVGYNRN LAKGKAPHGP SFTIGKAIWL
460 470 480 490 500
LWGLVFNNSV PVQNPKGTTS KIMVSVWAFF AVIFLASYTA NLAAFMIQEE
510 520 530 540 550
FVDQVTGLSD KKFQRPHDYS PPFRFGTVPN GSTERNIRNN YPYMHQYMTK
560 570 580 590 600
FNQKGVEDAL VSLKTGKLDA FIYDAAVLNY KAGRDEGCKL VTIGSGYIFA
610 620 630 640 650
TTGYGIALQK GSPWKRQIDL ALLQFVGDGE MEELETLWLT GICHNEKNEV
660 670 680 690 700
MSSQLDIDNM AGVFYMLAAA MALSLITFIW EHLFYWKLRF CFTGVCSDRP
710 720 730 740 750
GLLFSISRGI YSCIHGVHIE EKKKSPDFNL TGSQSNMLKL LRSAKNISSM
760 770 780 790 800
SNMNSSRMDS PKRAADFIQR GSLIMDMVSD KGNLMYSDNR SFQGKESIFG
810 820 830 840 850
DNMNELQTFV ANRQKDNLNN YVFQGQHPLT LNESNPNTVE VAVSTESKAN
860 870 880 890 900
SRPRQLWKKS VDSIRQDSLS QNPVSQRDEA TAENRTHSLK SPRYLPEEMA
910 920 930 940 950
HSDISETSNR ATCHREPDNS KNHKTKDNFK RSVASKYPKD CSEVERTYLK
960 970 980 990 1000
TKSSSPRDKI YTIDGEKEPG FHLDPPQFVE NVTLPENVDF PDPYQDPSEN
1010 1020 1030 1040 1050
FRKGDSTLPM NRNPLHNEEG LSNKDQYKLY SKHFTLKDKG SPHSETSERY
1060 1070 1080 1090 1100
RQNSTHCRSC LSNMPTYSGH FTMRSPFKCD ACLRMGNLHD IDEDQMLQET
1110 1120
GMTNAWLLGD APRTLTNTRC HPRR
Length:1,124
Mass (Da):127,609
Last modified:September 23, 2008 - v1
Checksum:i183311901E07BF3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295620 mRNA. Translation: BAG58499.1.
UniGeneiHs.411472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295620 mRNA. Translation: BAG58499.1.
UniGeneiHs.411472.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4DII7.

Protocols and materials databases

DNASUi2903.
Structural Biology KnowledgebaseSearch...

Organism-specific databases

PharmGKBiPA28979.

Phylogenomic databases

HOVERGENiHBG052635.

Miscellaneous databases

GenomeRNAii2903.
NextBioi11495.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.

Entry informationi

Entry nameiB4DII7_HUMAN
AccessioniPrimary (citable) accession number: B4DII7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 4, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.