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B4DI81

- B4DI81_HUMAN

UniProt

B4DI81 - B4DI81_HUMAN

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Protein
Gap junction protein
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.UniRule annotation

GO - Molecular functioni

  1. transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ATP transport Source: Ensembl
  2. apoptotic process Source: Ensembl
  3. cell-cell signaling Source: Ensembl
  4. cellular response to mechanical stimulus Source: Ensembl
  5. chronic inflammatory response Source: Ensembl
  6. endothelium development Source: Ensembl
  7. heart development Source: Ensembl
  8. negative regulation of cardiac muscle cell proliferation Source: Ensembl
  9. neuron projection morphogenesis Source: Ensembl
  10. positive regulation of behavioral fear response Source: Ensembl
  11. positive regulation of cell communication by chemical coupling Source: Ensembl
  12. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  13. positive regulation of glomerular filtration Source: Ensembl
  14. positive regulation of protein catabolic process Source: Ensembl
  15. positive regulation of vasoconstriction Source: Ensembl
  16. positive regulation of vasodilation Source: Ensembl
  17. protein oligomerization Source: Ensembl
  18. regulation of calcium ion transport Source: Ensembl
  19. regulation of tight junction assembly Source: Ensembl
  20. response to fluid shear stress Source: Ensembl
  21. response to pH Source: Ensembl
  22. response to peptide hormone Source: Ensembl
  23. vascular transport Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. connexon complex Source: InterPro
  3. early endosome Source: Ensembl
  4. fascia adherens Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. lysosome Source: Ensembl
  7. membrane raft Source: Ensembl
  8. mitochondrial outer membrane Source: Ensembl
  9. multivesicular body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotations, Gap junctionUniRule annotationSAAS annotations, Membrane

Expressioni

Gene expression databases

ArrayExpressiB4DI81.
BgeeiB4DI81.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG009576.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DI81-1 [UniParc]FASTAAdd to Basket

« Hide

MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS    50
AFRCNTQQPG CENVCYDKSF PISHVFYVMR KEEKLNKKEE ELKVAQTDGV 100
NVDMHLKQIE IKKFKYGIEE HGKVKMRGGL LRTYIISILF KSIFEVAFLL 150
IQWYIYGFSL SAVYTCKRDP CPHQVDCFLS RPTEKTIFII FMLVVSLVSL 200
ALNIIELFYV FFKGVKDRVK GKSDPYHATS GALSPAKDCG SQKYAYFNGC 250
SSPTAPLSPM SPPGYKLVTG DRNNSSCRNY NKQASEQNWA NYSAEQNRMG 300
QAGSTISNSH AQPFDFPDDN QNSKKLAAGH ELQPLAIVDQ RPSSRASSRA 350
SSRPRPDDLE I 361
Length:361
Mass (Da):40,511
Last modified:September 23, 2008 - v1
Checksum:i0AF852C2413E6D00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295460 mRNA. Translation: BAG58393.1.
UniGeneiHs.74471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295460 mRNA. Translation: BAG58393.1 .
UniGenei Hs.74471.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009576.

Miscellaneous databases

NextBioi 35472209.

Gene expression databases

ArrayExpressi B4DI81.
Bgeei B4DI81.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.

Entry informationi

Entry nameiB4DI81_HUMAN
AccessioniPrimary (citable) accession number: B4DI81
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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