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B4DI81

- B4DI81_HUMAN

UniProt

B4DI81 - B4DI81_HUMAN

Protein

Gap junction protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotation

    GO - Molecular functioni

    1. transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: Ensembl
    2. ATP transport Source: Ensembl
    3. cell-cell signaling Source: Ensembl
    4. cellular response to mechanical stimulus Source: Ensembl
    5. chronic inflammatory response Source: Ensembl
    6. endothelium development Source: Ensembl
    7. heart development Source: Ensembl
    8. negative regulation of cardiac muscle cell proliferation Source: Ensembl
    9. neuron projection morphogenesis Source: Ensembl
    10. positive regulation of behavioral fear response Source: Ensembl
    11. positive regulation of cell communication by chemical coupling Source: Ensembl
    12. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    13. positive regulation of glomerular filtration Source: Ensembl
    14. positive regulation of protein catabolic process Source: Ensembl
    15. positive regulation of vasoconstriction Source: Ensembl
    16. positive regulation of vasodilation Source: Ensembl
    17. protein oligomerization Source: Ensembl
    18. regulation of calcium ion transport Source: Ensembl
    19. regulation of tight junction assembly Source: Ensembl
    20. response to fluid shear stress Source: Ensembl
    21. response to peptide hormone Source: Ensembl
    22. response to pH Source: Ensembl
    23. vascular transport Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction proteinUniRule annotation
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation. Cell junctiongap junction SAAS annotation
    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. early endosome Source: Ensembl
    3. fascia adherens Source: Ensembl
    4. Golgi apparatus Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. lysosome Source: Ensembl
    7. membrane raft Source: Ensembl
    8. mitochondrial outer membrane Source: Ensembl
    9. multivesicular body Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiB4DI81.
    BgeeiB4DI81.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the connexin family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG009576.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002261. Connexin43.
    IPR013124. Connexin43_C.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF03508. Connexin43. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01132. CONNEXINA1.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4DI81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS    50
    AFRCNTQQPG CENVCYDKSF PISHVFYVMR KEEKLNKKEE ELKVAQTDGV 100
    NVDMHLKQIE IKKFKYGIEE HGKVKMRGGL LRTYIISILF KSIFEVAFLL 150
    IQWYIYGFSL SAVYTCKRDP CPHQVDCFLS RPTEKTIFII FMLVVSLVSL 200
    ALNIIELFYV FFKGVKDRVK GKSDPYHATS GALSPAKDCG SQKYAYFNGC 250
    SSPTAPLSPM SPPGYKLVTG DRNNSSCRNY NKQASEQNWA NYSAEQNRMG 300
    QAGSTISNSH AQPFDFPDDN QNSKKLAAGH ELQPLAIVDQ RPSSRASSRA 350
    SSRPRPDDLE I 361
    Length:361
    Mass (Da):40,511
    Last modified:September 23, 2008 - v1
    Checksum:i0AF852C2413E6D00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295460 mRNA. Translation: BAG58393.1.
    UniGeneiHs.74471.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295460 mRNA. Translation: BAG58393.1 .
    UniGenei Hs.74471.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG009576.

    Miscellaneous databases

    NextBioi 35472209.

    Gene expression databases

    ArrayExpressi B4DI81.
    Bgeei B4DI81.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002261. Connexin43.
    IPR013124. Connexin43_C.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF03508. Connexin43. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01132. CONNEXINA1.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HippocampusImported.

    Entry informationi

    Entry nameiB4DI81_HUMAN
    AccessioniPrimary (citable) accession number: B4DI81
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.