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Protein

Gap junction protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 45HelicalSequence analysisAdd BLAST22
Transmembranei133 – 155HelicalSequence analysisAdd BLAST23
Transmembranei187 – 212HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiB4DI81

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 76CNXInterPro annotationAdd BLAST34
Domaini144 – 210Connexin_CCCInterPro annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 98Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the connexin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG009576

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
1.20.5.1130, 1 hit
InterProiView protein in InterPro
IPR035091 Alpha_helix_dom_sf
IPR000500 Connexin
IPR002261 Connexin43
IPR013124 Connexin43_C
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 2 hits
PTHR11984:SF33 PTHR11984:SF33, 2 hits
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF03508 Connexin43, 1 hit
PRINTSiPR00206 CONNEXIN
PR01132 CONNEXINA1
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

B4DI81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS
60 70 80 90 100
AFRCNTQQPG CENVCYDKSF PISHVFYVMR KEEKLNKKEE ELKVAQTDGV
110 120 130 140 150
NVDMHLKQIE IKKFKYGIEE HGKVKMRGGL LRTYIISILF KSIFEVAFLL
160 170 180 190 200
IQWYIYGFSL SAVYTCKRDP CPHQVDCFLS RPTEKTIFII FMLVVSLVSL
210 220 230 240 250
ALNIIELFYV FFKGVKDRVK GKSDPYHATS GALSPAKDCG SQKYAYFNGC
260 270 280 290 300
SSPTAPLSPM SPPGYKLVTG DRNNSSCRNY NKQASEQNWA NYSAEQNRMG
310 320 330 340 350
QAGSTISNSH AQPFDFPDDN QNSKKLAAGH ELQPLAIVDQ RPSSRASSRA
360
SSRPRPDDLE I
Length:361
Mass (Da):40,511
Last modified:September 23, 2008 - v1
Checksum:i0AF852C2413E6D00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295460 mRNA Translation: BAG58393.1
UniGeneiHs.700699
Hs.74471

Similar proteinsi

Entry informationi

Entry nameiB4DI81_HUMAN
AccessioniPrimary (citable) accession number: B4DI81
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health