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B4DHT6

- B4DHT6_HUMAN

UniProt

B4DHT6 - B4DHT6_HUMAN

Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

    GO - Molecular functioni

    1. glucosylceramidase activity Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. sphingolipid metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotation, Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolismUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Pathology & Biotechi

    Protein family/group databases

    Allergomei8244. Hom s Glucocerebrosidase.

    PTM / Processingi

    Proteomic databases

    PRIDEiB4DHT6.

    Structurei

    3D structure databases

    ProteinModelPortaliB4DHT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 30 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000270031.
    HOVERGENiHBG002285.
    PhylomeDBiB4DHT6.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR11069. PTHR11069. 1 hit.
    PfamiPF02055. Glyco_hydro_30. 1 hit.
    [Graphical view]
    PRINTSiPR00843. GLHYDRLASE30.
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4DHT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSSPSREE CPKPSGRVSI MAGSLTGLLL LQAVSWASDE CLQPLQEQKQ    50
    WALDGAEYRT IQANCTGTGI GYNIIWVPMA SCDFSIRTYT YADTPDDFQL 100
    HNFSLPEEDT KLKIPLIHRA LQLAQRPVSL LASPWTSPTR LKTKGAGNGK 150
    GPLKGQPRDI YHQTWARYIV KFLDAYAEHK LQFWAVTAEN EPSAGLLSGY 200
    PFQCLGFTPE HQRDFIARDL GPTLANGTHH NVRLLMLDDQ RLLLPHWAKV 250
    VLTDPEAAKY VHGIAVHWYL DFLAPAKATL RETHHLFPNT MLFASEACVG 300
    SKFWEQSVRL GSWDRGMQYS HSIITNLLYH VVGWTDWNPS L 341
    Length:341
    Mass (Da):38,476
    Last modified:September 23, 2008 - v1
    Checksum:iEB9B41EAABC5141A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295259 mRNA. Translation: BAG58248.1.
    UniGeneiHs.719930.

    Genome annotation databases

    UCSCiuc001fjd.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295259 mRNA. Translation: BAG58248.1 .
    UniGenei Hs.719930.

    3D structure databases

    ProteinModelPortali B4DHT6.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 8244. Hom s Glucocerebrosidase.

    Proteomic databases

    PRIDEi B4DHT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc001fjd.3. human.

    Phylogenomic databases

    HOGENOMi HOG000270031.
    HOVERGENi HBG002285.
    PhylomeDBi B4DHT6.

    Miscellaneous databases

    NextBioi 35472100.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR11069. PTHR11069. 1 hit.
    Pfami PF02055. Glyco_hydro_30. 1 hit.
    [Graphical view ]
    PRINTSi PR00843. GLHYDRLASE30.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Caudate nucleusImported.

    Entry informationi

    Entry nameiB4DHT6_HUMAN
    AccessioniPrimary (citable) accession number: B4DHT6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.