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Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

  1. glucosylceramidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. sphingolipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Protein family/group databases

Allergomei8244. Hom s Glucocerebrosidase.

PTM / Processingi

Proteomic databases

PRIDEiB4DHT6.

Structurei

3D structure databases

ProteinModelPortaliB4DHT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000270031.
HOVERGENiHBG002285.
PhylomeDBiB4DHT6.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DHT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSSPSREE CPKPSGRVSI MAGSLTGLLL LQAVSWASDE CLQPLQEQKQ
60 70 80 90 100
WALDGAEYRT IQANCTGTGI GYNIIWVPMA SCDFSIRTYT YADTPDDFQL
110 120 130 140 150
HNFSLPEEDT KLKIPLIHRA LQLAQRPVSL LASPWTSPTR LKTKGAGNGK
160 170 180 190 200
GPLKGQPRDI YHQTWARYIV KFLDAYAEHK LQFWAVTAEN EPSAGLLSGY
210 220 230 240 250
PFQCLGFTPE HQRDFIARDL GPTLANGTHH NVRLLMLDDQ RLLLPHWAKV
260 270 280 290 300
VLTDPEAAKY VHGIAVHWYL DFLAPAKATL RETHHLFPNT MLFASEACVG
310 320 330 340
SKFWEQSVRL GSWDRGMQYS HSIITNLLYH VVGWTDWNPS L
Length:341
Mass (Da):38,476
Last modified:September 23, 2008 - v1
Checksum:iEB9B41EAABC5141A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295259 mRNA. Translation: BAG58248.1.
UniGeneiHs.719930.

Genome annotation databases

UCSCiuc001fjd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295259 mRNA. Translation: BAG58248.1.
UniGeneiHs.719930.

3D structure databases

ProteinModelPortaliB4DHT6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei8244. Hom s Glucocerebrosidase.

Proteomic databases

PRIDEiB4DHT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc001fjd.3. human.

Phylogenomic databases

HOGENOMiHOG000270031.
HOVERGENiHBG002285.
PhylomeDBiB4DHT6.

Miscellaneous databases

NextBioi35472100.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Caudate nucleusImported.

Entry informationi

Entry nameiB4DHT6_HUMAN
AccessioniPrimary (citable) accession number: B4DHT6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.