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Protein
Submitted name:

cDNA FLJ55539, highly similar to NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei456Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLigaseImported, TransferaseSAAS annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ55539, highly similar to NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-)Imported
Submitted name:
cDNA, FLJ78996, highly similar to NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Interactioni

Protein-protein interaction databases

IntActiB4DHF6. 1 interactor.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 55WWInterPro annotationAdd BLAST33
Domaini62 – 95WWInterPro annotationAdd BLAST34
Domaini154 – 488HECT (E6AP-type E3 ubiquitin-protein ligase)InterPro annotationAdd BLAST335

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
HOVERGENiHBG004134.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
cd00201. WW. 2 hits.
InterProiView protein in InterPro
IPR000569. HECT_dom.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF00632. HECT. 1 hit.
PF00397. WW. 2 hits.
SMARTiView protein in SMART
SM00119. HECTc. 1 hit.
SM00456. WW. 2 hits.
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiView protein in PROSITE
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

B4DHF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHFSQRFLY QSSSASTDHD PLGPLPPGWE KRQDNGRVYY VNHNTRTTQW
60 70 80 90 100
EDPRTQGMIQ EPALPPGWEM KYTSEGVRYF VDHNTRTTTF KDPRPGFESG
110 120 130 140 150
TKQGSPGAYD RSFRWKYHQF RFLCHSNALP SHVKISVSRQ TLFEDSFQQI
160 170 180 190 200
MNMKPYDLRR RLYIIMRGEE GLDYGGIARE WFFLLSHEVL NPMYCLFEYA
210 220 230 240 250
GKNNYCLQIN PASSINPDHL TYFRFIGRFI AMALYHGKFI DTGFTLPFYK
260 270 280 290 300
RMLNKRPTLK DLESIDPEFY NSIVWIKENN LEECGLELYF IQDMEILGKV
310 320 330 340 350
TTHELKEGGE SIRVTEENKE EYIMLLTDWR FTRGVEEQTK AFLDGFNEVA
360 370 380 390 400
PLEWLRYFDE KELELMLCGM QEIDMSDWQK STIYRHYTKN SKQIQWFWQV
410 420 430 440 450
VKEMDNEKRI RLLQFVTGTC RLPVGGFAEL IGSNGPQKFC IDKVGKETWL
460 470 480
PRSHTCFNRL DLPPYKSYEQ LREKLLYAIE ETEGFGQE
Length:488
Mass (Da):57,781
Last modified:September 23, 2008 - v1
Checksum:iAA073578DF0D4E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295070 mRNA. Translation: BAG58117.1.
AK316097 mRNA. Translation: BAH14468.1.
RefSeqiNP_001257382.1. NM_001270453.1.
NP_955456.1. NM_199424.2.
UniGeneiHs.408458.

Genome annotation databases

GeneIDi11060.

Similar proteinsi

Entry informationi

Entry nameiB4DHF6_HUMAN
AccessioniPrimary (citable) accession number: B4DHF6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: August 30, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.