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Protein
Submitted name:

cDNA FLJ55539, highly similar to NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ55539, highly similar to NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-)Imported
Submitted name:
cDNA, FLJ78996, highly similar to NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiB4DHF6.

Expressioni

Gene expression databases

BgeeiENSG00000198373.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5533WWInterPro annotationAdd
BLAST
Domaini62 – 9534WWInterPro annotationAdd
BLAST
Domaini154 – 488335HECT (E6AP-type E3 ubiquitin-protein ligase)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains HECT (E6AP-type E3 ubiquitin-protein ligase) domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
HOVERGENiHBG004134.

Family and domain databases

InterProiIPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DHF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHFSQRFLY QSSSASTDHD PLGPLPPGWE KRQDNGRVYY VNHNTRTTQW
60 70 80 90 100
EDPRTQGMIQ EPALPPGWEM KYTSEGVRYF VDHNTRTTTF KDPRPGFESG
110 120 130 140 150
TKQGSPGAYD RSFRWKYHQF RFLCHSNALP SHVKISVSRQ TLFEDSFQQI
160 170 180 190 200
MNMKPYDLRR RLYIIMRGEE GLDYGGIARE WFFLLSHEVL NPMYCLFEYA
210 220 230 240 250
GKNNYCLQIN PASSINPDHL TYFRFIGRFI AMALYHGKFI DTGFTLPFYK
260 270 280 290 300
RMLNKRPTLK DLESIDPEFY NSIVWIKENN LEECGLELYF IQDMEILGKV
310 320 330 340 350
TTHELKEGGE SIRVTEENKE EYIMLLTDWR FTRGVEEQTK AFLDGFNEVA
360 370 380 390 400
PLEWLRYFDE KELELMLCGM QEIDMSDWQK STIYRHYTKN SKQIQWFWQV
410 420 430 440 450
VKEMDNEKRI RLLQFVTGTC RLPVGGFAEL IGSNGPQKFC IDKVGKETWL
460 470 480
PRSHTCFNRL DLPPYKSYEQ LREKLLYAIE ETEGFGQE
Length:488
Mass (Da):57,781
Last modified:September 23, 2008 - v1
Checksum:iAA073578DF0D4E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295070 mRNA. Translation: BAG58117.1.
AK316097 mRNA. Translation: BAH14468.1.
RefSeqiNP_001257382.1. NM_001270453.1.
NP_955456.1. NM_199424.2.
UniGeneiHs.408458.

Genome annotation databases

GeneIDi11060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295070 mRNA. Translation: BAG58117.1.
AK316097 mRNA. Translation: BAH14468.1.
RefSeqiNP_001257382.1. NM_001270453.1.
NP_955456.1. NM_199424.2.
UniGeneiHs.408458.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348283.

Proteomic databases

PeptideAtlasiB4DHF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11060.

Organism-specific databases

CTDi11060.

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
HOVERGENiHBG004134.

Miscellaneous databases

GenomeRNAii11060.

Gene expression databases

BgeeiENSG00000198373.

Family and domain databases

InterProiIPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DHF6_HUMAN
AccessioniPrimary (citable) accession number: B4DHF6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.