ABCB7

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	479 – 486	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity, coupled to transmembrane movement of substances Source: InterPro
ATP binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	ATP-bindingPROSITE-ProRule annotationImported, Nucleotide-binding

Ligand

ATP-bindingPROSITE-ProRule annotationImported, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: ATP-binding cassette sub-family B member 7, mitochondrialImported Submitted name: cDNA FLJ53391, highly similar to ATP-binding cassette sub-family B member 7, mitochondrialImported
Gene namesⁱ	Name:ABCB7Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131269.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:48 ABCB7

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	114 – 139	HelicalSequence analysisAdd BLAST	26
Transmembraneⁱ	159 – 180	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	234 – 261	HelicalSequence analysisAdd BLAST	28
Transmembraneⁱ	267 – 288	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	357 – 379	HelicalSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000131269

OpenTargetsⁱ

ENSG00000131269

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000131269

Bgeeⁱ

ENSG00000131269

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	115 – 410	ABC transmembrane type-1InterPro annotationAdd BLAST		296
Domainⁱ	446 – 680	ABC transporterInterPro annotationAdd BLAST		235

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0057 Eukaryota COG5265 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033373
HOVERGENⁱ	HBG080810

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 1 hit PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

B4DGL8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALLAMHSWR WAAAAAAFEK RRHSAILIRP LVSVSGSGPQ WRPHQLGALG 
        60         70         80         90        100
TARAYQALQV WPLIEKRTCW HGHAGGGLHT DPKEGLKDVD TRKIIKAMLS 
       110        120        130        140        150
YVWPKDRPDL RARVAISLGF LGGAKAMNIV VPFMFKYAVD SLNQMSGNML 
       160        170        180        190        200
NLSDAPNTVA TMATAVLIGY GVSRAGAAFF NEVRNAVFGK VAQNSIRRIA 
       210        220        230        240        250
KNVFLHLHNL DLGFHLSRQT GALSKAIDRG TRGISFVLSA LVFNLLPIMF 
       260        270        280        290        300
EVMLVSGVLY YKCGAQFALV TLGTLGTYTA FTVAVTRWRT RFRIEMNKAD 
       310        320        330        340        350
NDAGNAAIDS LLNYETVKYF NNERYEAQRY DGFLKTYETA SLKSTSTLAM 
       360        370        380        390        400
LNFGQSAIFS VGLTAIMVLA SQGIVAGTLT VGDLVMVNGL LFQLSLPLNF 
       410        420        430        440        450
LGTVYRETRQ ALIDMNTLFT LLKVDTQIKD KVMASPLQIT PQTATVAFDN 
       460        470        480        490        500
VHFEYIEGQK VLSGISFEVP AGKKVAIVGG SGSGKSTIVR LLFRFYEPQK 
       510        520        530        540        550
GSIYLAGQNI QDVSLESLRR AVGVVPQDAV LFHNTIYYNL LYGNISASPE 
       560        570        580        590        600
EVYAVAKLAG LHDAILRMPH GYDTQVGERG LKLSGGEKQR VAIARAILKD 
       610        620        630        640        650
PPVILYDEAT SSLDSITEET ILGAMKDVVK HRTSIFIAHR LSTVVDADEI 
       660        670        680        690        700
IVLDQGKVAE RGTHHGLLAN PHSIYSEMWH TQSSRVQNHD NPKWEAKKEN 

IS

Length:702

Mass (Da):77,121

Last modified:September 23, 2008 - v1

Checksum:ⁱ165821EACE3CB9E9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	702	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL359545 Genomic DNA No translation available. AL360179 Genomic DNA No translation available. AL590232 Genomic DNA No translation available. AK294657 mRNA Translation: BAG57829.1
UniGeneⁱ	Hs.370480

Genome annotation databases

Ensemblⁱ	ENST00000529949; ENSP00000436586; ENSG00000131269
UCSC genome browser More...UCSCⁱ	uc065aab.1 human

Protein	Similar proteins		Species	Score	Length
B4DGL8	ATP-binding cassette sub-family B member 7, mitochondrial		HUMAN		752
ATP binding cassette subfamily B member 7		PAPAN		799
ATP binding cassette subfamily B member 7		CHLSB		698
ATP binding cassette subfamily B member 7		MACFA		799
ATP binding cassette subfamily B member 7		MACNE		799
+135

Protein	Similar proteins		Species	Score	Length
B4DGL8	ATP-binding cassette sub-family B member 7, mitochondrial		HUMAN		752
ATP binding cassette subfamily B member 7		MACFA		799
ATP binding cassette subfamily B member 7		MACNE		799
ATP binding cassette subfamily B member 7		MACMU		753
ATP binding cassette subfamily B member 7		PAPAN		799
+462

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL359545 Genomic DNA No translation available. AL360179 Genomic DNA No translation available. AL590232 Genomic DNA No translation available. AK294657 mRNA Translation: BAG57829.1
UniGeneⁱ	Hs.370480

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000529949; ENSP00000436586; ENSG00000131269
UCSC genome browser More...UCSCⁱ	uc065aab.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131269.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:48 ABCB7
Open Targets More...OpenTargetsⁱ	ENSG00000131269
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0057 Eukaryota COG5265 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033373
HOVERGENⁱ	HBG080810

Miscellaneous databases

ChiTaRSⁱ	ABCB7 human
GenomeRNAiⁱ	22

Gene expression databases

Bgeeⁱ	ENSG00000131269

Bgeeⁱ

ENSG00000131269

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 1 hit PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B4DGL8_HUMAN
Accessionⁱ	B4DGL8Primary (citable) accession number: B4DGL8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 23, 2008
	Last sequence update:	September 23, 2008
	Last modified:	May 23, 2018
	This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B4DGL8 (B4DGL8_HUMAN)

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ATP-binding cassette sub-family B member 7, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Expressionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ