UniProtKB - B4DGL8 (B4DGL8_HUMAN)
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Protein
Submitted name:
ATP-binding cassette sub-family B member 7, mitochondrial
Gene
ABCB7
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 479 – 486 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity, coupled to transmembrane movement of substances Source: InterPro
- ATP binding Source: UniProtKB-UniRule
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationImported, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette sub-family B member 7, mitochondrialImportedSubmitted name: cDNA FLJ53391, highly similar to ATP-binding cassette sub-family B member 7, mitochondrialImported |
Gene namesi | Name:ABCB7Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000131269.15. |
HGNCi | HGNC:48. ABCB7. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 114 – 139 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 159 – 180 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 234 – 261 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 267 – 288 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 357 – 379 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 115 – 410 | ABC transmembrane type-1InterPro annotationAdd BLAST | 296 | |
Domaini | 446 – 680 | ABC transporterInterPro annotationAdd BLAST | 235 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG0057. Eukaryota. COG5265. LUCA. |
GeneTreei | ENSGT00440000033373. |
HOVERGENi | HBG080810. |
Family and domain databases
Gene3Di | 1.20.1560.10. 1 hit. |
InterProi | View protein in InterPro IPR003593. AAA+_ATPase. IPR011527. ABC1_TM_dom. IPR036640. ABC1_TM_sf. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR027417. P-loop_NTPase. |
Pfami | View protein in Pfam PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. |
SMARTi | View protein in SMART SM00382. AAA. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. SSF90123. SSF90123. 1 hit. |
PROSITEi | View protein in PROSITE PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. |
i Sequence
Sequence statusi: Fragment.
B4DGL8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLAMHSWR WAAAAAAFEK RRHSAILIRP LVSVSGSGPQ WRPHQLGALG
60 70 80 90 100
TARAYQALQV WPLIEKRTCW HGHAGGGLHT DPKEGLKDVD TRKIIKAMLS
110 120 130 140 150
YVWPKDRPDL RARVAISLGF LGGAKAMNIV VPFMFKYAVD SLNQMSGNML
160 170 180 190 200
NLSDAPNTVA TMATAVLIGY GVSRAGAAFF NEVRNAVFGK VAQNSIRRIA
210 220 230 240 250
KNVFLHLHNL DLGFHLSRQT GALSKAIDRG TRGISFVLSA LVFNLLPIMF
260 270 280 290 300
EVMLVSGVLY YKCGAQFALV TLGTLGTYTA FTVAVTRWRT RFRIEMNKAD
310 320 330 340 350
NDAGNAAIDS LLNYETVKYF NNERYEAQRY DGFLKTYETA SLKSTSTLAM
360 370 380 390 400
LNFGQSAIFS VGLTAIMVLA SQGIVAGTLT VGDLVMVNGL LFQLSLPLNF
410 420 430 440 450
LGTVYRETRQ ALIDMNTLFT LLKVDTQIKD KVMASPLQIT PQTATVAFDN
460 470 480 490 500
VHFEYIEGQK VLSGISFEVP AGKKVAIVGG SGSGKSTIVR LLFRFYEPQK
510 520 530 540 550
GSIYLAGQNI QDVSLESLRR AVGVVPQDAV LFHNTIYYNL LYGNISASPE
560 570 580 590 600
EVYAVAKLAG LHDAILRMPH GYDTQVGERG LKLSGGEKQR VAIARAILKD
610 620 630 640 650
PPVILYDEAT SSLDSITEET ILGAMKDVVK HRTSIFIAHR LSTVVDADEI
660 670 680 690 700
IVLDQGKVAE RGTHHGLLAN PHSIYSEMWH TQSSRVQNHD NPKWEAKKEN
IS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 702 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL359545 Genomic DNA. No translation available. AL360179 Genomic DNA. No translation available. AL590232 Genomic DNA. No translation available. AK294657 mRNA. Translation: BAG57829.1. |
UniGenei | Hs.370480. |
Genome annotation databases
Ensembli | ENST00000529949; ENSP00000436586; ENSG00000131269. |
UCSCi | uc065aab.1. human. |
Similar proteinsi
Entry informationi
Entry namei | B4DGL8_HUMAN | |
Accessioni | B4DGL8Primary (citable) accession number: B4DGL8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | March 28, 2018 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |