ABCB7

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	479 – 486	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity, coupled to transmembrane movement of substances Source: InterPro
ATP binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	ATP-bindingPROSITE-ProRule annotationImported, Nucleotide-binding

Ligand

ATP-bindingPROSITE-ProRule annotationImported, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: ATP-binding cassette sub-family B member 7, mitochondrialImported Submitted name: cDNA FLJ53391, highly similar to ATP-binding cassette sub-family B member 7, mitochondrialImported
Gene namesⁱ	Name:ABCB7Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131269.15.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:48. ABCB7.

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	114 – 139	HelicalSequence analysisAdd BLAST	26
Transmembraneⁱ	159 – 180	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	234 – 261	HelicalSequence analysisAdd BLAST	28
Transmembraneⁱ	267 – 288	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	357 – 379	HelicalSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000131269.

OpenTargetsⁱ

ENSG00000131269.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000131269.

Bgeeⁱ

ENSG00000131269.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	115 – 410	ABC transmembrane type-1InterPro annotationAdd BLAST		296
Domainⁱ	446 – 680	ABC transporterInterPro annotationAdd BLAST		235

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0057. Eukaryota. COG5265. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033373.
HOVERGENⁱ	HBG080810.

Family and domain databases

Gene3Dⁱ	1.20.1560.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003593. AAA+_ATPase. IPR011527. ABC1_TM_dom. IPR036640. ABC1_TM_sf. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit.
SMARTⁱ	View protein in SMART SM00382. AAA. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit. SSF90123. SSF90123. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

B4DGL8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALLAMHSWR WAAAAAAFEK RRHSAILIRP LVSVSGSGPQ WRPHQLGALG 
        60         70         80         90        100
TARAYQALQV WPLIEKRTCW HGHAGGGLHT DPKEGLKDVD TRKIIKAMLS 
       110        120        130        140        150
YVWPKDRPDL RARVAISLGF LGGAKAMNIV VPFMFKYAVD SLNQMSGNML 
       160        170        180        190        200
NLSDAPNTVA TMATAVLIGY GVSRAGAAFF NEVRNAVFGK VAQNSIRRIA 
       210        220        230        240        250
KNVFLHLHNL DLGFHLSRQT GALSKAIDRG TRGISFVLSA LVFNLLPIMF 
       260        270        280        290        300
EVMLVSGVLY YKCGAQFALV TLGTLGTYTA FTVAVTRWRT RFRIEMNKAD 
       310        320        330        340        350
NDAGNAAIDS LLNYETVKYF NNERYEAQRY DGFLKTYETA SLKSTSTLAM 
       360        370        380        390        400
LNFGQSAIFS VGLTAIMVLA SQGIVAGTLT VGDLVMVNGL LFQLSLPLNF 
       410        420        430        440        450
LGTVYRETRQ ALIDMNTLFT LLKVDTQIKD KVMASPLQIT PQTATVAFDN 
       460        470        480        490        500
VHFEYIEGQK VLSGISFEVP AGKKVAIVGG SGSGKSTIVR LLFRFYEPQK 
       510        520        530        540        550
GSIYLAGQNI QDVSLESLRR AVGVVPQDAV LFHNTIYYNL LYGNISASPE 
       560        570        580        590        600
EVYAVAKLAG LHDAILRMPH GYDTQVGERG LKLSGGEKQR VAIARAILKD 
       610        620        630        640        650
PPVILYDEAT SSLDSITEET ILGAMKDVVK HRTSIFIAHR LSTVVDADEI 
       660        670        680        690        700
IVLDQGKVAE RGTHHGLLAN PHSIYSEMWH TQSSRVQNHD NPKWEAKKEN 

IS

Length:702

Mass (Da):77,121

Last modified:September 23, 2008 - v1

Checksum:ⁱ165821EACE3CB9E9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	702	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL359545 Genomic DNA. No translation available. AL360179 Genomic DNA. No translation available. AL590232 Genomic DNA. No translation available. AK294657 mRNA. Translation: BAG57829.1.
UniGeneⁱ	Hs.370480.

Genome annotation databases

Ensemblⁱ	ENST00000529949; ENSP00000436586; ENSG00000131269.
UCSC genome browser More...UCSCⁱ	uc065aab.1. human.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B4DGL8	O75027 A0A2K5WVE4 A0A2K6DSA7 H9F0L7 G7NS55 G7Q326 A0A096MXT6 A0A0D9RET1 UPI00045E5476 UPI0003AB9219 +133	Homo sapiens (Human) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Macaca mulatta (Rhesus macaque) Papio anubis (Olive baboon) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Heterocephalus glaber (Naked mole rat) Trichechus manatus latirostris (Florida manatee) Microtus ochrogaster (Prairie vole) And more	752	UniRef90_O75027	Cluster: ATP-binding cassette sub-family B member 7, mitochondrial	144

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B4DGL8	O75027 A0A096MXT6 A0A0D9RET1 A0A2K5WVE4 A0A2K6DSA7 H9F0L7 G7NS55 G7Q326 UPI00045E5476 UPI0005F4CD43 +192	Homo sapiens (Human) Papio anubis (Olive baboon) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Macaca mulatta (Rhesus macaque) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Heterocephalus glaber (Naked mole rat) Trichechus manatus latirostris (Florida manatee) Microtus ochrogaster (Prairie vole) And more	752	UniRef50_O75027	Cluster: ATP-binding cassette sub-family B member 7, mitochondrial	203

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL359545 Genomic DNA. No translation available. AL360179 Genomic DNA. No translation available. AL590232 Genomic DNA. No translation available. AK294657 mRNA. Translation: BAG57829.1.
UniGeneⁱ	Hs.370480.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000529949; ENSP00000436586; ENSG00000131269.
UCSC genome browser More...UCSCⁱ	uc065aab.1. human.

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131269.15.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:48. ABCB7.
Open Targets More...OpenTargetsⁱ	ENSG00000131269.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0057. Eukaryota. COG5265. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033373.
HOVERGENⁱ	HBG080810.

Miscellaneous databases

ChiTaRSⁱ	ABCB7. human.
GenomeRNAiⁱ	22.

Gene expression databases

Bgeeⁱ	ENSG00000131269.

Bgeeⁱ

ENSG00000131269.

Family and domain databases

Gene3Dⁱ	1.20.1560.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003593. AAA+_ATPase. IPR011527. ABC1_TM_dom. IPR036640. ABC1_TM_sf. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit.
SMARTⁱ	View protein in SMART SM00382. AAA. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit. SSF90123. SSF90123. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B4DGL8_HUMAN
Accessionⁱ	B4DGL8Primary (citable) accession number: B4DGL8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 23, 2008
	Last sequence update:	September 23, 2008
	Last modified:	March 28, 2018
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B4DGL8 (B4DGL8_HUMAN)

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ATP-binding cassette sub-family B member 7, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Expressionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ