B4DG79 (B4DG79_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ55487, highly similar to RAC-beta serine/threonine-protein kinase (EC2.7.11.1) EMBL BAG57690.1
Organism	Homo sapiens (Human) EMBL BAG57690.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. SAAS SAAS017892
Sequence similarities	Contains 1 AGC-kinase C-terminal domain. SAAS SAAS017892

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS017892 RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS017892 Transferase
Gene Ontology (GO)
Biological_process	activation of Ral GTPase activity Inferred from electronic annotation. Source: Compara insulin receptor signaling pathway Inferred from electronic annotation. Source: Compara peripheral nervous system myelin maintenance Inferred from electronic annotation. Source: Compara positive regulation of glucose import in response to insulin stimulus Inferred from electronic annotation. Source: Compara protein localization to plasma membrane Inferred from electronic annotation. Source: Compara regulation of JNK cascade Inferred from electronic annotation. Source: Compara
Cellular_component	lamellipodium Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4DG79 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 67AEDEBB2CDC2D53	FASTA	419	48,502
	10 20 30 40 50 60 MKTERPRPNT FVIRCLQWTT VIERTFHVDS PDEREEWMRA IQMVANSLKQ RAPGEDPMDY 70 80 90 100 110 120 KCGSPSDSST TEEMEVAVSK ARAKVTMNDF DYLKLLGKGT FGKVILVREK ATGRYYAMKI 130 140 150 160 170 180 LRKEVIIAKD EVAHTVTESR VLQNTRHPFL TALKYAFQTH DRLCFVMEYA NGGELFFHLS 190 200 210 220 230 240 RERVFTEERA RFYGAEIVSA LEYLHSRDVV YRDIKLENLM LDKDGHIKIT DFGLCKEGIS 250 260 270 280 290 300 DGATMKTFCG TPEYLAPEVL EDNDYGRAVD WWGLGVVMYE MMCGRLPFYN QDHERLFELI 310 320 330 340 350 360 LMEEIRFPRT LSPEAKSLLA GLLKKDPKQR LGGGPSDAKE VMEHRFFLSI NWQDVVQKKL 370 380 390 400 410 LPPFKPQVTS EVDTRYFDDE FTAQSITITP PDRYDSLGLL ELDQRTHFPQ FSYSASIRE

References

[1]

"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Amygdala EMBL BAG57690.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK294453 mRNA. Translation: BAG57690.1.
IPI	IPI00012870.
RefSeq	NP_001229956.1. NM_001243027.1. NP_001229957.1. NM_001243028.1.
UniGene	Hs.631535.
3D structure databases
ProteinModelPortal	B4DG79.
ModBase	Search...
Protein-protein interaction databases
STRING	B4DG79.
Protocols and materials databases
DNASU	208.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	208.
KEGG	hsa:208.
Organism-specific databases
CTD	208.
Phylogenomic databases
HOVERGEN	HBG108317.
KO	K04456.
Gene expression databases
ArrayExpress	B4DG79.
Bgee	B4DG79.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR011993. PH_like_dom. IPR017892. Pkinase_C. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	B4DG79.
GenomeRNAi	208.
NextBio	836.

Entry information

Entry name

B4DG79_HUMAN

Accession

Primary (citable) accession number: B4DG79

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.