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Protein
Submitted name:

cDNA FLJ55487, highly similar to RAC-beta serine/threonine-protein kinase (EC2.7.11.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. insulin receptor signaling pathway Source: Ensembl
  2. intracellular protein transmembrane transport Source: Ensembl
  3. peripheral nervous system myelin maintenance Source: Ensembl
  4. positive regulation of glucose import in response to insulin stimulus Source: Ensembl
  5. positive regulation of protein phosphorylation Source: Ensembl
  6. positive regulation of protein targeting to membrane Source: Ensembl
  7. positive regulation of vesicle fusion Source: Ensembl
  8. protein localization to plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB4DG79.

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ55487, highly similar to RAC-beta serine/threonine-protein kinase (EC2.7.11.1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. ruffle membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB4DG79.

Expressioni

Gene expression databases

BgeeiB4DG79.
ExpressionAtlasiB4DG79. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliB4DG79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG108317.
KOiK04456.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DG79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTERPRPNT FVIRCLQWTT VIERTFHVDS PDEREEWMRA IQMVANSLKQ
60 70 80 90 100
RAPGEDPMDY KCGSPSDSST TEEMEVAVSK ARAKVTMNDF DYLKLLGKGT
110 120 130 140 150
FGKVILVREK ATGRYYAMKI LRKEVIIAKD EVAHTVTESR VLQNTRHPFL
160 170 180 190 200
TALKYAFQTH DRLCFVMEYA NGGELFFHLS RERVFTEERA RFYGAEIVSA
210 220 230 240 250
LEYLHSRDVV YRDIKLENLM LDKDGHIKIT DFGLCKEGIS DGATMKTFCG
260 270 280 290 300
TPEYLAPEVL EDNDYGRAVD WWGLGVVMYE MMCGRLPFYN QDHERLFELI
310 320 330 340 350
LMEEIRFPRT LSPEAKSLLA GLLKKDPKQR LGGGPSDAKE VMEHRFFLSI
360 370 380 390 400
NWQDVVQKKL LPPFKPQVTS EVDTRYFDDE FTAQSITITP PDRYDSLGLL
410
ELDQRTHFPQ FSYSASIRE
Length:419
Mass (Da):48,502
Last modified:September 23, 2008 - v1
Checksum:i67AEDEBB2CDC2D53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294453 mRNA. Translation: BAG57690.1.
RefSeqiNP_001229956.1. NM_001243027.2.
NP_001229957.1. NM_001243028.2.
UniGeneiHs.631535.

Genome annotation databases

GeneIDi208.
KEGGihsa:208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294453 mRNA. Translation: BAG57690.1.
RefSeqiNP_001229956.1. NM_001243027.2.
NP_001229957.1. NM_001243028.2.
UniGeneiHs.631535.

3D structure databases

ProteinModelPortaliB4DG79.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiB4DG79.

Proteomic databases

PRIDEiB4DG79.

Protocols and materials databases

DNASUi208.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi208.
KEGGihsa:208.

Organism-specific databases

CTDi208.

Phylogenomic databases

HOVERGENiHBG108317.
KOiK04456.

Enzyme and pathway databases

SignaLinkiB4DG79.

Miscellaneous databases

GenomeRNAii208.
NextBioi836.

Gene expression databases

BgeeiB4DG79.
ExpressionAtlasiB4DG79. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported.

Entry informationi

Entry nameiB4DG79_HUMAN
AccessioniPrimary (citable) accession number: B4DG79
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 29, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.