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B4DG68 (B4DG68_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length1206 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produces nitric oxide (NO) By similarity. PIRNR PIRNR000333

Catalytic activity

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O. PIRNR PIRNR000333

Cofactor

Binds 1 FAD By similarity. PIRNR PIRNR000333

Binds 1 FMN By similarity. PIRNR PIRNR000333

Heme group By similarity. PIRNR PIRNR000333

Sequence similarities

Belongs to the NOS family. PIRNR PIRNR000333

Contains 1 PDZ (DHR) domain. RuleBase RU003354

Sequences

Sequence LengthMass (Da)Tools
B4DG68 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: E4DBC7937045D909

FASTA1,206134,816
        10         20         30         40         50         60 
MEDHMFGVQQ IQPNVISVRL FKRKVGGLGF LVKERVSKPP VIISDLIRGG AAEQSGLIQA 

        70         80         90        100        110        120 
GDIILAVNGR PLVDLSYDSA LEVLRGIASE THVVLILRGP EGFTTHLETT FTGDGTPKTI 

       130        140        150        160        170        180 
RVTQPLGPPT KAVDLSHQPP AGKEQPLAVD GASGPGNGPQ HAYDDGQEAG SLPHANGLAP 

       190        200        210        220        230        240 
RPPGQDPAKK ATRVSLQGRG ENNELLKEIE PVLSLLTSGS RGVKGGAPAK AEMKDMGIQV 

       250        260        270        280        290        300 
DRDLDGKSHK PLPLGVENDR VFNDLWGKGN VPVVLNNPYS EKEQPPTSGK QSPTKNGSPS 

       310        320        330        340        350        360 
KCPRFLKVKN WETEVVLTDT LHLKSTLETG CTEYICMGSI MHPSQHARRP EDVRTKGQLF 

       370        380        390        400        410        420 
PLAKEFIDQY YSSIKRFGSK AHMERLEEVN KEIDTTSTYQ LKDTELIYGA KHAWRNASRC 

       430        440        450        460        470        480 
VGRIQWSKLQ VFDARDCTTA HGMFNYICNH VKYATNKGNL RSAITIFPQR TDGKHDFRVW 

       490        500        510        520        530        540 
NSQLIRYAGY KQPDGSTLGD PANVQFTEIC IQQGWKPPRG RFDVLPLLLQ ANVNDPELFQ 

       550        560        570        580        590        600 
IPPELVLEVP IRHPKFEWFK DLGLKWYGLP AVSNMLLEIG GLEFSACPFS GWYMGTEIGV 

       610        620        630        640        650        660 
RDYCDNSRYN ILEEVAKKLN LDMRKTSSLW KDQALVEINI AVLYSFQSDK VTIVDHHSAT 

       670        680        690        700        710        720 
ESFIKHMENE YRCRGGCPAD WVWIVPPMSG SITPVFHQEM LNYRLTPSFE YQPDPWNTHV 

       730        740        750        760        770        780 
WKGTNGTPTK RRAIGFKKLA EAVKFSAKLM GQAMAKRVKA TILYATETGK SQAYAKTLCE 

       790        800        810        820        830        840 
IFKHAFDAKV MSMEEYDIVH LEHETLVLVV TSTFGNGDPP ENGEKFGCAL MEMRHPNSVQ 

       850        860        870        880        890        900 
EERKSYKVRF NSVSSYSDSQ KSSGDGPDLR DNFESAGPLA NVRFSVFGLG SRAYPHFCAF 

       910        920        930        940        950        960 
GHAVDTLLEE LGGERILKMR EGDELCGQEE AFRTWAKKVF KAACDVFCVG DDVNIEKANN 

       970        980        990       1000       1010       1020 
SLISNDRSWK RNKFRLTFVA EAPELTQGLS NVHKKRVSAA RLLSRQNLQS PKSSRSTIFV 

      1030       1040       1050       1060       1070       1080 
RLHTNGSQEL QYQPGDHLGV FPGNHEDLVN ALIERLEDAP PVNQMVKVEL LEERNTALGV 

      1090       1100       1110       1120       1130       1140 
ISNWTDELRL PPCTIFQAFK YYLDITTPPT PLQLQQFASL ATSEKEKQRL LVLSKGLQEY 

      1150       1160       1170       1180       1190       1200 
EEWKWGKNPT IVEVLEEFPS IQMPATLLLT QLSLLQPRYY SISSSPHTHT LSETRPSPLP 


LSSQCC 

« Hide

References

[1]"NEDO human cDNA sequencing project focused on splicing variants."
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. expand/collapse author list , Sugano S., Nomura N., Isogai T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Amygdala EMBL BAG57679.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK294435 mRNA. Translation: BAG57679.1.
RefSeqNP_000611.1. NM_000620.4.
NP_001191142.1. NM_001204213.1.
NP_001191143.1. NM_001204214.1.
NP_001191147.1. NM_001204218.1.
UniGeneHs.654410.
Hs.684465.
Hs.684466.
Hs.684467.
Hs.735734.

3D structure databases

ProteinModelPortalB4DG68.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEB4DG68.

Protocols and materials databases

DNASU4842.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4842.
KEGGhsa:4842.

Organism-specific databases

CTD4842.

Phylogenomic databases

HOGENOMHOG000220884.
HOVERGENHBG000159.
KOK13240.

Family and domain databases

Gene3D1.20.990.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProIPR003097. FAD-binding_1.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR004030. NO_synthase_oxygenase_dom.
IPR012144. NOS_euk.
IPR001478. PDZ.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF02898. NO_synthase. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PIRSFPIRSF000333. NOS. 1 hit.
PRINTSPR00369. FLAVODOXIN.
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
SSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEPS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi4842.
NextBio18658.

Entry information

Entry nameB4DG68_HUMAN
AccessionPrimary (citable) accession number: B4DG68
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.