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Protein

Non-specific serine/threonine protein kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165Proton acceptorUniRule annotation1
Active sitei510Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Ribonucleoprotein, Ribosomal proteinImported, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB4DG22

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiB4DG22
PeptideAtlasiB4DG22
PRIDEiB4DG22

Structurei

3D structure databases

ProteinModelPortaliB4DG22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 299Protein kinaseInterPro annotationAdd BLAST260
Domaini300 – 369AGC-kinase C-terminalInterPro annotationAdd BLAST70
Domaini393 – 650Protein kinaseInterPro annotationAdd BLAST258

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
HOVERGENiHBG108317

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016239 Ribosomal_S6_kinase_II
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000606 Ribsml_S6_kin_2, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 2 hits
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 2 hits
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

Sequencei

Sequence statusi: Complete.

B4DG22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEPMGEEEI NPQTEEVSIK EIAITHHVKE GHEKADPSQF ELLKVLGQGS
60 70 80 90 100
FGKVFLVKKI SGSDARQLYA MKVLKKATLK VRDRVRTKME RDILVEVNHP
110 120 130 140 150
FIVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTEE DVKFYLAELA
160 170 180 190 200
LALDHLHSLG IIYRDLKPEN ILLDEEGHIK LTDFGLSKES IDHEKKAYSF
210 220 230 240 250
CGTVEYMAPE VVNRRGHTQS ADWWSFGVLM FEMLTGTLPF QGKDRKETMT
260 270 280 290 300
MILKAKLGMP QFLSPEAQSL LRMLFKRNPA NRLGAGPDGV EEIKRHSFFS
310 320 330 340 350
TIDWNKLYRR EIHPPFKPAT GRPEDTFYFD PEFTAKTPKD SPGIPPSANA
360 370 380 390 400
HQLFRGFSFV AITSDDESQA MQTVGVHSIV QLHRNSIQFT DGYEVKEDIG
410 420 430 440 450
VGSYSVCKRC IHKATNMEFA VKIIDKSKRD PTEEIEILLR YGQHPNIITL
460 470 480 490 500
KDVYDDGKYV YVVTELMKGG ELLDKILRQK FFSEREASAV LFTITKTVEY
510 520 530 540 550
LHAQGVVHRD LKPSNILYVD ESGNPESIRI CDFGFAKQLR AENGLLMTPC
560 570 580 590 600
YTANFVAPEV LKRQGYDAAC DIWSLGVLLY TMLTGYTPFA NGPDDTPEEI
610 620 630 640 650
LARIGSGKFS LSGGYWNSVS DTAKDLVSKM LHVDPHQRLT AALVLRHPWI
660 670 680 690 700
VHWDQLPQYQ LNRQDAPHLV KGAMAATYSA LNRNQSPVLE PVGRSTLAQR
710
RGIKKITSTA L
Length:711
Mass (Da):80,583
Last modified:September 23, 2008 - v1
Checksum:iD4383824A75BEB03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294373 mRNA Translation: BAG57633.1
RefSeqiXP_006724570.1, XM_006724507.3
XP_016885208.1, XM_017029719.1
UniGeneiHs.445387

Genome annotation databases

GeneIDi6197

Similar proteinsi

Entry informationi

Entry nameiB4DG22_HUMAN
AccessioniPrimary (citable) accession number: B4DG22
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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