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Protein
Submitted name:

cDNA FLJ56618, highly similar to Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ribonucleoprotein, Ribosomal proteinImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB4DG22.

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ56618, highly similar to Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiB4DG22.
MaxQBiB4DG22.
PaxDbiB4DG22.

Expressioni

Gene expression databases

BgeeiB4DG22.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368884.

Structurei

3D structure databases

ProteinModelPortaliB4DG22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 299260Protein kinaseInterPro annotationAdd
BLAST
Domaini300 – 36970AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini393 – 650258Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
HOVERGENiHBG108317.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DG22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEPMGEEEI NPQTEEVSIK EIAITHHVKE GHEKADPSQF ELLKVLGQGS
60 70 80 90 100
FGKVFLVKKI SGSDARQLYA MKVLKKATLK VRDRVRTKME RDILVEVNHP
110 120 130 140 150
FIVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTEE DVKFYLAELA
160 170 180 190 200
LALDHLHSLG IIYRDLKPEN ILLDEEGHIK LTDFGLSKES IDHEKKAYSF
210 220 230 240 250
CGTVEYMAPE VVNRRGHTQS ADWWSFGVLM FEMLTGTLPF QGKDRKETMT
260 270 280 290 300
MILKAKLGMP QFLSPEAQSL LRMLFKRNPA NRLGAGPDGV EEIKRHSFFS
310 320 330 340 350
TIDWNKLYRR EIHPPFKPAT GRPEDTFYFD PEFTAKTPKD SPGIPPSANA
360 370 380 390 400
HQLFRGFSFV AITSDDESQA MQTVGVHSIV QLHRNSIQFT DGYEVKEDIG
410 420 430 440 450
VGSYSVCKRC IHKATNMEFA VKIIDKSKRD PTEEIEILLR YGQHPNIITL
460 470 480 490 500
KDVYDDGKYV YVVTELMKGG ELLDKILRQK FFSEREASAV LFTITKTVEY
510 520 530 540 550
LHAQGVVHRD LKPSNILYVD ESGNPESIRI CDFGFAKQLR AENGLLMTPC
560 570 580 590 600
YTANFVAPEV LKRQGYDAAC DIWSLGVLLY TMLTGYTPFA NGPDDTPEEI
610 620 630 640 650
LARIGSGKFS LSGGYWNSVS DTAKDLVSKM LHVDPHQRLT AALVLRHPWI
660 670 680 690 700
VHWDQLPQYQ LNRQDAPHLV KGAMAATYSA LNRNQSPVLE PVGRSTLAQR
710
RGIKKITSTA L
Length:711
Mass (Da):80,583
Last modified:September 23, 2008 - v1
Checksum:iD4383824A75BEB03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294373 mRNA. Translation: BAG57633.1.
RefSeqiXP_006724570.1. XM_006724507.2.
UniGeneiHs.445387.

Genome annotation databases

GeneIDi6197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294373 mRNA. Translation: BAG57633.1.
RefSeqiXP_006724570.1. XM_006724507.2.
UniGeneiHs.445387.

3D structure databases

ProteinModelPortaliB4DG22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368884.

Proteomic databases

EPDiB4DG22.
MaxQBiB4DG22.
PaxDbiB4DG22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6197.

Organism-specific databases

CTDi6197.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
HOVERGENiHBG108317.

Enzyme and pathway databases

SignaLinkiB4DG22.

Miscellaneous databases

ChiTaRSiRPS6KA3. human.
GenomeRNAii6197.

Gene expression databases

BgeeiB4DG22.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported.

Entry informationi

Entry nameiB4DG22_HUMAN
AccessioniPrimary (citable) accession number: B4DG22
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.