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Protein
Submitted name:

Mitogen-activated protein kinase kinase 1, isoform CRA_d

Gene

MAP2K1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase 1, isoform CRA_dImported
Submitted name:
cDNA FLJ58770, highly similar to Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2)Imported
Gene namesi
Name:MAP2K1Imported
ORF Names:hCG_24510Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiB4DFY5
PRIDEiB4DFY5

Structurei

3D structure databases

SMRiB4DFY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 339Protein kinaseInterPro annotationAdd BLAST294

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 28Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0581 Eukaryota
ENOG410XQ5A LUCA
HOVERGENiHBG108518

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

B4DFY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLERTNLEA LQKKLEELEL DEQQRKRLEA FLTQKQKVGE LKDDDFEKIS
60 70 80 90 100
ELGAGNGGVV FKVSHKPSGL VMARKLIHLE IKPAIRNQII RELQVLHECN
110 120 130 140 150
SPYIVGFYGA FYSDGEISIC MEHMDGGSLD QVLKKAGRIP EQILGKVSIA
160 170 180 190 200
VIKGLTYLRE KHKIMHRDVK PSNILVNSRG EIKLCDFGVS GQLIDSMANS
210 220 230 240 250
FVGTRSYMSP ERLQGTHYSV QSDIWSMGLS LVEMAVGRYP IPPPDAKELE
260 270 280 290 300
LMFGCQVEGD AAETPPRPRT PGRPLSSYGM DSRPPMAIFE LLDYIVNEPP
310 320 330 340 350
PKLPSGVFSL EFQDFVNKCL IKNPAERADL KQLMVHAFIK RSDAEEVDFA
360 370
GWLCSTIGLN QPSTPTHAAG V
Length:371
Mass (Da):41,379
Last modified:September 23, 2008 - v1
Checksum:i34BDCD7C6B3CCD6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294322 mRNA Translation: BAG57596.1
CH471082 Genomic DNA Translation: EAW77768.1
RefSeqiXP_011520085.1, XM_011521783.2
UniGeneiHs.145442
Hs.677223

Genome annotation databases

GeneIDi5604

Similar proteinsi

Entry informationi

Entry nameiB4DFY5_HUMAN
AccessioniPrimary (citable) accession number: B4DFY5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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