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B4DFV1

- B4DFV1_HUMAN

UniProt

B4DFV1 - B4DFV1_HUMAN

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Protein

Protein kinase C

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein kinase C activity Source: UniProtKB-EC

GO - Biological processi

  1. B cell proliferation Source: Ensembl
  2. defense response to bacterium Source: Ensembl
  3. immunoglobulin mediated immune response Source: Ensembl
  4. interleukin-10 production Source: Ensembl
  5. interleukin-12 production Source: Ensembl
  6. intracellular signal transduction Source: InterPro
  7. negative regulation of actin filament polymerization Source: Ensembl
  8. negative regulation of filopodium assembly Source: Ensembl
  9. negative regulation of insulin receptor signaling pathway Source: Ensembl
  10. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  11. negative regulation of platelet aggregation Source: Ensembl
  12. positive regulation of apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

SignaLinkiB4DFV1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CUniRule annotation (EC:2.7.11.13UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nuclear matrix Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB4DFV1.

Expressioni

Gene expression databases

BgeeiB4DFV1.
ExpressionAtlasiB4DFV1. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliB4DFV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

HOVERGENiHBG108317.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000551. PKC_delta. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DFV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAAEEPVSE VTVGVSVLAE RCKKNNGKAE FWLDLQPQAK VLMSVQYFLE
60 70 80 90 100
DVDCKQSMRS EDEAKFPTMN RRGAIKQAKI HYIKNHEFIA TFFGQPTFCS
110 120 130 140 150
VCKDFVWGLN KQGYKCRQCN AAIHKKCIDK IIGRCTGTAA NSRDTIFQKE
160 170 180 190 200
RFNIDMPHRF KVHNYMSPTF CDHCGSLLWG LVKQGLKCED CGMNVHHKCR
210 220 230 240 250
EKVANLCGIN QKLLAEALNQ VTQRASRRSD SASSEPVGIY QGFEKKTGVA
260 270 280 290 300
GEDMQDNSGT YGKIWEGSSK CNINNFIFHK VLGKGSFGKV LLGELKGRGE
310 320 330 340 350
YFAIKALKKD VVLIDDDVEC TMVEKRVLTL AAENPFLTHL ICTFQTKDHL
360 370 380 390 400
FFVMEFLNGG DLMYHIQDKG RFELYRATFY AAEIMCGLQF LHSKGIIYRD
410 420 430 440 450
LKLDNVLLDR DGHIKIADFG MCKENIFGES RASTFCGTPD YIAPEILQGL
460 470 480 490 500
KYTFSVDWWS FGVLLYEMLI GQSPFHGDDE DELFESIRVD TPHYPRWITK
510 520 530 540 550
ESKDILEKLF EREPTKRLGV TGNIKIHPFF KTINWTLLEK RRLEPPFRPK
560 570 580 590 600
VKSPRDYSNF DQEFLNEKAR LSYSDKNLID SMDQSAFAGF SFVNPKFEHL

LED
Length:603
Mass (Da):69,156
Last modified:September 23, 2008 - v1
Checksum:iFE9640A8D32F7C77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK294272 mRNA. Translation: BAG57562.1.
UniGeneiHs.155342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK294272 mRNA. Translation: BAG57562.1 .
UniGenei Hs.155342.

3D structure databases

ProteinModelPortali B4DFV1.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi B4DFV1.

Proteomic databases

PRIDEi B4DFV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108317.

Enzyme and pathway databases

SignaLinki B4DFV1.

Miscellaneous databases

NextBioi 35471591.

Gene expression databases

Bgeei B4DFV1.
ExpressionAtlasi B4DFV1. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000551. PKC_delta. 1 hit.
PRINTSi PR00008. DAGPEDOMAIN.
SMARTi SM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported.

Entry informationi

Entry nameiB4DFV1_HUMAN
AccessioniPrimary (citable) accession number: B4DFV1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.