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B4DFV1

- B4DFV1_HUMAN

UniProt

B4DFV1 - B4DFV1_HUMAN

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Protein

Protein kinase C

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein kinase C activity Source: UniProtKB-EC

GO - Biological processi

  1. B cell proliferation Source: Ensembl
  2. defense response to bacterium Source: Ensembl
  3. immunoglobulin mediated immune response Source: Ensembl
  4. interleukin-10 production Source: Ensembl
  5. interleukin-12 production Source: Ensembl
  6. intracellular signal transduction Source: InterPro
  7. negative regulation of actin filament polymerization Source: Ensembl
  8. negative regulation of filopodium assembly Source: Ensembl
  9. negative regulation of insulin receptor signaling pathway Source: Ensembl
  10. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  11. negative regulation of platelet aggregation Source: Ensembl
  12. positive regulation of apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

SignaLinkiB4DFV1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CUniRule annotation (EC:2.7.11.13UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nuclear matrix Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB4DFV1.

Expressioni

Gene expression databases

ArrayExpressiB4DFV1.
BgeeiB4DFV1.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliB4DFV1.

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotations
Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

HOVERGENiHBG108317.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000551. PKC_delta. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DFV1-1 [UniParc]FASTAAdd to Basket

« Hide

MRAAEEPVSE VTVGVSVLAE RCKKNNGKAE FWLDLQPQAK VLMSVQYFLE    50
DVDCKQSMRS EDEAKFPTMN RRGAIKQAKI HYIKNHEFIA TFFGQPTFCS 100
VCKDFVWGLN KQGYKCRQCN AAIHKKCIDK IIGRCTGTAA NSRDTIFQKE 150
RFNIDMPHRF KVHNYMSPTF CDHCGSLLWG LVKQGLKCED CGMNVHHKCR 200
EKVANLCGIN QKLLAEALNQ VTQRASRRSD SASSEPVGIY QGFEKKTGVA 250
GEDMQDNSGT YGKIWEGSSK CNINNFIFHK VLGKGSFGKV LLGELKGRGE 300
YFAIKALKKD VVLIDDDVEC TMVEKRVLTL AAENPFLTHL ICTFQTKDHL 350
FFVMEFLNGG DLMYHIQDKG RFELYRATFY AAEIMCGLQF LHSKGIIYRD 400
LKLDNVLLDR DGHIKIADFG MCKENIFGES RASTFCGTPD YIAPEILQGL 450
KYTFSVDWWS FGVLLYEMLI GQSPFHGDDE DELFESIRVD TPHYPRWITK 500
ESKDILEKLF EREPTKRLGV TGNIKIHPFF KTINWTLLEK RRLEPPFRPK 550
VKSPRDYSNF DQEFLNEKAR LSYSDKNLID SMDQSAFAGF SFVNPKFEHL 600
LED 603
Length:603
Mass (Da):69,156
Last modified:September 23, 2008 - v1
Checksum:iFE9640A8D32F7C77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK294272 mRNA. Translation: BAG57562.1.
UniGeneiHs.155342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK294272 mRNA. Translation: BAG57562.1 .
UniGenei Hs.155342.

3D structure databases

ProteinModelPortali B4DFV1.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi B4DFV1.

Proteomic databases

PRIDEi B4DFV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108317.

Enzyme and pathway databases

SignaLinki B4DFV1.

Miscellaneous databases

NextBioi 35471591.

Gene expression databases

ArrayExpressi B4DFV1.
Bgeei B4DFV1.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000551. PKC_delta. 1 hit.
PRINTSi PR00008. DAGPEDOMAIN.
SMARTi SM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported.

Entry informationi

Entry nameiB4DFV1_HUMAN
AccessioniPrimary (citable) accession number: B4DFV1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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