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B4DFV1 (B4DFV1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length603 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. PIRNR PIRNR000551 SAAS SAAS017892

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. PIRNR PIRNR000551

Contains AGC-kinase C-terminal domain. SAAS SAAS017892

Contains protein kinase domain. SAAS SAAS017892

Ontologies

Keywords
   DomainZinc-finger SAAS SAAS017892
   LigandATP-binding PIRNR PIRNR000551 SAAS SAAS017892 RuleBase RU000304
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Serine/threonine-protein kinase PIRNR PIRNR000551 SAAS SAAS017892
Transferase
Gene Ontology (GO)
   Biological_processB cell proliferation

Inferred from electronic annotation. Source: Ensembl

defense response to bacterium

Inferred from electronic annotation. Source: Ensembl

immunoglobulin mediated immune response

Inferred from electronic annotation. Source: Ensembl

interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

negative regulation of actin filament polymerization

Inferred from electronic annotation. Source: Ensembl

negative regulation of filopodium assembly

Inferred from electronic annotation. Source: Ensembl

negative regulation of insulin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of platelet aggregation

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell-cell junction

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

nuclear matrix

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein kinase C activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B4DFV1 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: FE9640A8D32F7C77

FASTA60369,156
        10         20         30         40         50         60 
MRAAEEPVSE VTVGVSVLAE RCKKNNGKAE FWLDLQPQAK VLMSVQYFLE DVDCKQSMRS 

        70         80         90        100        110        120 
EDEAKFPTMN RRGAIKQAKI HYIKNHEFIA TFFGQPTFCS VCKDFVWGLN KQGYKCRQCN 

       130        140        150        160        170        180 
AAIHKKCIDK IIGRCTGTAA NSRDTIFQKE RFNIDMPHRF KVHNYMSPTF CDHCGSLLWG 

       190        200        210        220        230        240 
LVKQGLKCED CGMNVHHKCR EKVANLCGIN QKLLAEALNQ VTQRASRRSD SASSEPVGIY 

       250        260        270        280        290        300 
QGFEKKTGVA GEDMQDNSGT YGKIWEGSSK CNINNFIFHK VLGKGSFGKV LLGELKGRGE 

       310        320        330        340        350        360 
YFAIKALKKD VVLIDDDVEC TMVEKRVLTL AAENPFLTHL ICTFQTKDHL FFVMEFLNGG 

       370        380        390        400        410        420 
DLMYHIQDKG RFELYRATFY AAEIMCGLQF LHSKGIIYRD LKLDNVLLDR DGHIKIADFG 

       430        440        450        460        470        480 
MCKENIFGES RASTFCGTPD YIAPEILQGL KYTFSVDWWS FGVLLYEMLI GQSPFHGDDE 

       490        500        510        520        530        540 
DELFESIRVD TPHYPRWITK ESKDILEKLF EREPTKRLGV TGNIKIHPFF KTINWTLLEK 

       550        560        570        580        590        600 
RRLEPPFRPK VKSPRDYSNF DQEFLNEKAR LSYSDKNLID SMDQSAFAGF SFVNPKFEHL 


LED 

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References

[1]"NEDO human cDNA sequencing project focused on splicing variants."
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. expand/collapse author list , Sugano S., Nomura N., Isogai T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Amygdala EMBL BAG57562.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK294272 mRNA. Translation: BAG57562.1.
UniGeneHs.155342.

3D structure databases

ProteinModelPortalB4DFV1.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBB4DFV1.

Proteomic databases

PRIDEB4DFV1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG108317.

Enzyme and pathway databases

SignaLinkB4DFV1.

Gene expression databases

ArrayExpressB4DFV1.
BgeeB4DFV1.

Family and domain databases

Gene3D2.60.40.150. 1 hit.
InterProIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFPIRSF000551. PKC_delta. 1 hit.
PRINTSPR00008. DAGPEDOMAIN.
SMARTSM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio35471591.

Entry information

Entry nameB4DFV1_HUMAN
AccessionPrimary (citable) accession number: B4DFV1
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.