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Protein
Submitted name:

Polycystin-2

Gene

PKD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi181 – 192PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Polycystin-2Imported
Submitted name:
cDNA FLJ50473, highly similar to Polycystin-2Imported
Gene namesi
Name:PKD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9009. PKD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Transmembranei77 – 98HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118762.

PTM / Processingi

Proteomic databases

MaxQBiB4DFN3.
PeptideAtlasiB4DFN3.

Expressioni

Gene expression databases

BgeeiENSG00000118762.
ExpressionAtlasiB4DFN3. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiB4DFN3. 6 interactors.
STRINGi9606.ENSP00000237596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 203EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 210Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
HOGENOMiHOG000069912.
HOVERGENiHBG102333.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
PfamiView protein in Pfam
PF08016. PKD_channel. 1 hit.
PRINTSiPR01433. POLYCYSTIN2.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B4DFN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLSTTMSR CAKDLFGFAI MFFIIFLAYA QLAYLVFGTQ VDDFSTFQEC
60 70 80 90 100
IFTQFRIILG DINFAEIEEA NRVLGPIYFT TFVFFMFFIL LNMFLAIIND
110 120 130 140 150
TYSEVKSDLA QQKAEMELSD LIRKGYHKAL VKLKLKKNTV DDISESLRQG
160 170 180 190 200
GGKLNFDELR QDLKGKGHTD AEIEAIFTKY DQDGDQELTE HEHQQMRDDL
210 220 230 240 250
EKEREDLDLD HSSLPRPMSS RSFPRSLDDS EEDDDEDSGH SSRRRGSISS
260 270 280 290 300
GVSYEEFQVL VRRVDRMEHS IGSIVSKIDA VIVKLEIMER AKLKRREVLG
310 320 330 340 350
RLLDGVAEDE RLGRDSEIHR EQMERLVREE LERWESDDAA SQISHGLGTP
360 370 380
VGLNGQPRPR SSRPSSSQST EGMEGAGGNG SSNVHV
Length:386
Mass (Da):43,915
Last modified:September 23, 2008 - v1
Checksum:iAD54E503EC20D793
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084732 Genomic DNA. No translation available.
AK294173 mRNA. Translation: BAG57494.1.
UniGeneiHs.181272.

Genome annotation databases

EnsembliENST00000502363; ENSP00000425289; ENSG00000118762.
ENST00000508588; ENSP00000427131; ENSG00000118762.
UCSCiuc011cdf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084732 Genomic DNA. No translation available.
AK294173 mRNA. Translation: BAG57494.1.
UniGeneiHs.181272.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB4DFN3. 6 interactors.
STRINGi9606.ENSP00000237596.

Proteomic databases

MaxQBiB4DFN3.
PeptideAtlasiB4DFN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502363; ENSP00000425289; ENSG00000118762.
ENST00000508588; ENSP00000427131; ENSG00000118762.
UCSCiuc011cdf.3. human.

Organism-specific databases

HGNCiHGNC:9009. PKD2.
OpenTargetsiENSG00000118762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
HOGENOMiHOG000069912.
HOVERGENiHBG102333.

Miscellaneous databases

ChiTaRSiPKD2. human.

Gene expression databases

BgeeiENSG00000118762.
ExpressionAtlasiB4DFN3. baseline and differential.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
PfamiView protein in Pfam
PF08016. PKD_channel. 1 hit.
PRINTSiPR01433. POLYCYSTIN2.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4DFN3_HUMAN
AccessioniPrimary (citable) accession number: B4DFN3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 15, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.