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Protein

Proteasome subunit alpha type

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha typeUniRule annotation (EC:3.4.25.1UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation
  • Nucleus SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei105 – 123HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, Membrane, NucleusUniRule annotationSAAS annotation, ProteasomeUniRule annotationImported

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256206.

PTM / Processingi

Proteomic databases

MaxQBiB4DEV8.
PeptideAtlasiB4DEV8.
PRIDEiB4DEV8.

Expressioni

Gene expression databases

BgeeiENSG00000129084.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000457299.

Structurei

3D structure databases

ProteinModelPortaliB4DEV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 28PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0863. Eukaryota.
COG0638. LUCA.
GeneTreeiENSGT00550000074855.
HOGENOMiHOG000069895.
HOVERGENiHBG104008.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DEV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK
60 70 80 90 100
RAQSELAAHQ KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD
110 120 130 140 150
RPLPVSRLVS LIGSSILFMI WALTFSKPVH LLTILTAEPC PLEPVPNQLV
160
LTWRDICLNL WSVI
Length:164
Mass (Da):18,458
Last modified:September 23, 2008 - v1
Checksum:i5AE4D0B5BD4E575D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018523 Genomic DNA. No translation available.
AK293813 mRNA. Translation: BAG57219.1.

Genome annotation databases

EnsembliENST00000555531; ENSP00000457299; ENSG00000256206.
UCSCiuc057zie.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018523 Genomic DNA. No translation available.
AK293813 mRNA. Translation: BAG57219.1.

3D structure databases

ProteinModelPortaliB4DEV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000457299.

Proteomic databases

MaxQBiB4DEV8.
PeptideAtlasiB4DEV8.
PRIDEiB4DEV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555531; ENSP00000457299; ENSG00000256206.
UCSCiuc057zie.1. human.

Organism-specific databases

OpenTargetsiENSG00000256206.

Phylogenomic databases

eggNOGiKOG0863. Eukaryota.
COG0638. LUCA.
GeneTreeiENSGT00550000074855.
HOGENOMiHOG000069895.
HOVERGENiHBG104008.

Miscellaneous databases

ChiTaRSiPSMA1. human.

Gene expression databases

BgeeiENSG00000129084.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DEV8_HUMAN
AccessioniPrimary (citable) accession number: B4DEV8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.