ID   B4DER6_HUMAN            Unreviewed;      1075 AA.
AC   B4DER6;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=cDNA FLJ51800, highly similar to Peroxisome biogenesis factor 1 {ECO:0000313|EMBL:BAG57177.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG57177.1};
RN   [1] {ECO:0000313|EMBL:BAG57177.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAG57177.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family.
CC       {ECO:0000256|ARBA:ARBA00006914}.
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DR   EMBL; AK293757; BAG57177.1; -; mRNA.
DR   RefSeq; NP_001269607.1; NM_001282678.1.
DR   AlphaFoldDB; B4DER6; -.
DR   SMR; B4DER6; -.
DR   PeptideAtlas; B4DER6; -.
DR   DNASU; 5189; -.
DR   GeneID; 5189; -.
DR   CTD; 5189; -.
DR   OrthoDB; 544017at2759; -.
DR   BioGRID-ORCS; 5189; 104 hits in 1162 CRISPR screens.
DR   GenomeRNAi; 5189; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:UniProt.
DR   CDD; cd19526; RecA-like_PEX1_r2; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR   PANTHER; PTHR23077:SF12; PEROXISOME BIOGENESIS FACTOR 1; 1.
DR   Pfam; PF00004; AAA; 2.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          383..533
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          665..801
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1052..1075
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..159
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1075 AA;  119603 MW;  552FDAF55C371506 CRC64;
     MMKELQTKQL QSNTVGITES NENESEIPVD SSSVASLWTM IGSIFSFQSE KKQETSWGLT
     EINAFKNMQS KVVPLDNIFR VCKSQPPSIY NASATSVFHK HCAIHVFPWD QEYFDVEPSF
     TVTYGKLVKL LSPKQQQSKT KQNVLSPEKE KQMSEPLDQK KIRSDHNEED EKACVLQVVW
     NGLEELNNAI KYTKNVEVLH LGKVWIPDDL RKRLNIEMHA VVRITPVEVT PKIPRSLKLQ
     PRENLPKDIS EEDIKTVFYS WLQQSTTTML PLVISEEEFI KLETKDGLKE FSLSIVHSWE
     KEKDKNIFLL SPNLLQKTTI QVLLDPMVKE ENSEEIDFIL PFLKLSSLGG VNSLGVSSLE
     HITHSLLGRP LSRQLMSLVA GLRNGALLLT GGKGSGKSTL AKAICKEAFD KLDAHVERVD
     CKALRGKRLE NIQKTLEVAF SEAVWMQPSV VLLDDLDLIA GLPAVPEHEH SPDAVQSQRL
     AHALNDMIKE FISMGSLVAL IATSQSQQSL HPLLVSAQGV HIFQCVQHIQ PPNQEQRCEI
     LCNVIKNKLD CDINKFTDLD LQHVAKETGG FVARDFTVLV DRAIHSRLSR QSISTREKLV
     LTTLDFQKAL RGFLPASLRS VNLHKPRDLG WDKIGGLHEV RQILMDTIQL PAKYPELFAN
     LPIRQRTGIL LYGPPGTGKT LLAGVIARES RMNFISVKGP ELLSKYIGAS EQAVRDIFIR
     AQAAKPCILF FDEFESIAPR RGHDNTGVTD RVVNQLLTQL DGVEGLQGVY VLAATSRPDL
     IDPALLRPGR LDKCVYCPPP DQVSRLEILN VLSDSLPLAD DVDLQHVASV TDSFTGADLK
     ALLYNAQLEA LHGMLLSSGL QDGSSSSDSD LSLSSMVFLN HSSGSDDSAG DGECGLDQSL
     VSLEMSEILP DESKFNMYRL YFGSSYESEL GNGTSSDLSS QCLSAPSSMT QDLPGVPGKD
     QLFSQPPVLR TASQEGCQEL TQEQRDQLRA DISIIKGRYR SQSGEDESMN QPGPIKTRLA
     ISQSHLMTAL GHTRPSISED DWKNFAELYE SFQNPKRRKN QSGTMFRPGQ KVTLA
//