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Protein

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts electrons from ETF and reduces ubiquinone.UniRule annotation

Catalytic activityi

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, Iron, Iron-sulfurUniRule annotation, Metal-binding, UbiquinoneUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialUniRule annotation (EC:1.5.5.1UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiB4DEQ0.
PeptideAtlasiB4DEQ0.

Expressioni

Gene expression databases

BgeeiENSG00000171503.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000426638.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini516 – 545304Fe-4S ferredoxin-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETF-QO/FixC family.UniRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
HOVERGENiHBG005615.
KOiK00311.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DEQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERFAEEADV VIVGAGPAGL SAAVRLKQLA VAHEKDIRVC LVEKAAQIGA
60 70 80 90 100
HTLSGACLDP GAFKELFPDW KEKGAPLNTP VTEDRFGILT EKYRIPVPIL
110 120 130 140 150
PGLPMNNHGN YIVRLGHLVS WMGEQAEALG VEVYPGYAAA EVLFHDDGSV
160 170 180 190 200
KGIATNDVGI QKDGAPKATF ERGLELHAKV TIFAEGCHGH LAKQLYKKFD
210 220 230 240 250
LRANCEPQTY GIGLKELWVI DEKNWKPGRV DHTVGWPLDR HTYGGSFLYH
260 270 280 290 300
LNEGEPLVAL GLVVGLDYQN PYLSPFREFQ RWKHHPSIRP TLEGGKRIAY
310 320 330 340 350
GARALNEGGF QSIPKLTFPG GLLIGCSPGF MNVPKIKGTH TAMKSGILAA
360 370 380 390 400
ESIFNQLTSE NLQSKTIGLH VTEYEDNLKN SWVWKELYSV RNIRPSCHGV
410 420 430 440 450
LGVYGGMIYT GIFYWILRGM EPWTLKHKGS DFERLKPAKD CTPIEYPKPD
460 470 480 490 500
GQISFDLLSS VALSGTNHEH DQPAHLTLRD DSIPVNRNLS IYDGPEQRFC
510 520 530 540 550
PAGVYEFVPV EQGDGFRLQI NAQNCVHCKT CDIKDPSQNI NWVVPEGGGG

PAYNGM
Length:556
Mass (Da):61,385
Last modified:September 23, 2008 - v1
Checksum:i837630BC794D78FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293737 mRNA. Translation: BAG57161.1.
RefSeqiNP_001268666.1. NM_001281737.1.
NP_001268667.1. NM_001281738.1.
NP_004444.2. NM_004453.3.
UniGeneiHs.155729.

Genome annotation databases

GeneIDi2110.
KEGGihsa:2110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293737 mRNA. Translation: BAG57161.1.
RefSeqiNP_001268666.1. NM_001281737.1.
NP_001268667.1. NM_001281738.1.
NP_004444.2. NM_004453.3.
UniGeneiHs.155729.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000426638.

Proteomic databases

PaxDbiB4DEQ0.
PeptideAtlasiB4DEQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2110.
KEGGihsa:2110.

Organism-specific databases

CTDi2110.

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
HOVERGENiHBG005615.
KOiK00311.

Miscellaneous databases

GenomeRNAii2110.

Gene expression databases

BgeeiENSG00000171503.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DEQ0_HUMAN
AccessioniPrimary (citable) accession number: B4DEQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.