cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31)

Functionⁱ

GO - Molecular functionⁱ

NAD+ binding Source: InterPro
transferase activity Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	TransferaseImported

Molecular function

TransferaseImported

Enzyme and pathway databases

SignaLinkⁱ	B4DDV3.

SignaLinkⁱ

B4DDV3.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31)Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B4DDV3.
PaxDbⁱ	B4DDV3.
PeptideAtlas More...PeptideAtlasⁱ	B4DDV3.
PRIDEⁱ	B4DDV3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000077463.

Bgeeⁱ

ENSG00000077463.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	B4DDV3. 12 interactors.

IntActⁱ

B4DDV3. 12 interactors.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B4DDV3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 202	Deacetylase sirtuin-typeInterPro annotationAdd BLAST		202

Phylogenomic databases

eggNOGⁱ	KOG1905. Eukaryota. COG0846. LUCA.
HOVERGENⁱ	HBG060028.

Family and domain databases

Gene3Dⁱ	3.40.50.1220. 1 hit.
InterProⁱ	View protein in InterPro IPR029035. DHS-like_NAD/FAD-binding_dom. IPR003000. Sirtuin. IPR026590. Ssirtuin_cat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02146. SIR2. 1 hit.
SUPFAMⁱ	SSF52467. SSF52467. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50305. SIRTUIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B4DDV3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEERGLAPKF DTTFESARPT QTHMALVQLE RVGLLRFLVS QNVDGLHVRS 
        60         70         80         90        100
GFPRDKLAEL HGNMFVEECA KCKTQYVRDT VVGTMGLKAT GRLCTVAKAR 
       110        120        130        140        150
GLRACRGELR DTILDWEDSL PDRDLALADE ASRNADLSIT LGTSLQIRPS 
       160        170        180        190        200
GNLPLATKRR GGRLVIVNLQ PTKHDRHADL RIHGYVDEVM TRLMKHLGLE 
       210        220        230        240        250
IPAWDGPRVL ERALPPLPRP PTPKLEPKEE SPTRINGSIP AGPKQEPCAQ 
       260        270        280 
HNGSEPASPK RERPTSPAPH RPPKRVKAKA VPS

Length:283

Mass (Da):31,319

Last modified:September 23, 2008 - v1

Checksum:ⁱ775740F80DA0ACE4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK293348 mRNA. Translation: BAG56864.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001307987.1. NM_001321058.1.
UniGeneⁱ	Hs.423756.

Genome annotation databases

GeneIDⁱ	51548.

GeneIDⁱ

51548.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK293348 mRNA. Translation: BAG56864.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001307987.1. NM_001321058.1.
UniGeneⁱ	Hs.423756.

3D structure databases

ProteinModelPortalⁱ	B4DDV3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	B4DDV3. 12 interactors.

IntActⁱ

B4DDV3. 12 interactors.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B4DDV3.
PaxDbⁱ	B4DDV3.
PeptideAtlas More...PeptideAtlasⁱ	B4DDV3.
PRIDEⁱ	B4DDV3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	51548.

GeneIDⁱ

51548.

Organism-specific databases

CTDⁱ	51548.

CTDⁱ

51548.

Phylogenomic databases

eggNOGⁱ	KOG1905. Eukaryota. COG0846. LUCA.
HOVERGENⁱ	HBG060028.

Enzyme and pathway databases

SignaLinkⁱ	B4DDV3.

SignaLinkⁱ

B4DDV3.

Miscellaneous databases

ChiTaRSⁱ	SIRT6. human.
GenomeRNAiⁱ	51548.

Gene expression databases

Bgeeⁱ	ENSG00000077463.

Bgeeⁱ

ENSG00000077463.

Family and domain databases

Gene3Dⁱ	3.40.50.1220. 1 hit.
InterProⁱ	View protein in InterPro IPR029035. DHS-like_NAD/FAD-binding_dom. IPR003000. Sirtuin. IPR026590. Ssirtuin_cat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02146. SIR2. 1 hit.
SUPFAMⁱ	SSF52467. SSF52467. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50305. SIRTUIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B4DDV3_HUMAN
Accessionⁱ	B4DDV3Primary (citable) accession number: B4DDV3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 23, 2008
	Last sequence update:	September 23, 2008
	Last modified:	July 5, 2017
	This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - B4DDV3 (B4DDV3_HUMAN)

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cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31)

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B4DDV3 (B4DDV3_HUMAN)

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cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31)

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ