ID   B4DDN2_HUMAN            Unreviewed;       461 AA.
AC   B4DDN2;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG56793.1};
RN   [1] {ECO:0000313|EMBL:BAG56793.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC       protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
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DR   EMBL; AK293261; BAG56793.1; -; mRNA.
DR   RefSeq; NP_001308153.1; NM_001321224.1.
DR   RefSeq; XP_016862720.1; XM_017007231.1.
DR   AlphaFoldDB; B4DDN2; -.
DR   PeptideAtlas; B4DDN2; -.
DR   ProteomicsDB; 3874; -.
DR   DNASU; 79858; -.
DR   GeneID; 79858; -.
DR   CTD; 79858; -.
DR   OrthoDB; 198307at2759; -.
DR   BioGRID-ORCS; 79858; 11 hits in 1182 CRISPR screens.
DR   GenomeRNAi; 79858; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR44899; CAMK FAMILY PROTEIN KINASE; 1.
DR   PANTHER; PTHR44899:SF3; SERINE_THREONINE PROTEIN KINASE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAG56793.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1..139
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          307..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          199..233
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   461 AA;  53164 MW;  BBC73A23BCA8FE78 CRC64;
     MHERRILHRD LKSKNVFLKN NLLKIGDFGV SRLLMGSCDL ATTLTGTPHY MSPEALKHQG
     YDTKSDIWSL ACILYEMCCM NHAFAGSNFL SIVLKIVEGD TPSLPERYPK ELNAIMESML
     NKNPSLRPSA IEILKIPYLD EQLQNLMCRY SEMTLEDKNL DCQKEAAHII NAMQKRIHLQ
     TLRALSEVQK MTPRERMRLR KLQAADEKAR KLKKIVEEKY EENSKRMQEL RSRNFQQLSV
     DVLHESDEPT LENLPESQPI PSMDLHELES IVEDATSDLG YHEIPEDPLV AEEYYADAFD
     SYCEESDEEE EEIALERPEK EIRNEGSQPA YRTNQQDSDI EALARCLENV LGCTSLDTKT
     ITTMAEDMSP GPPIFNSVMA RTKMKRMRES AMQKLGTEVF EEVYNYLKRA RHQNASEAEI
     RECLEKVVPQ ASDCFEVDQL LYFEEQLLIT MGKEPTLQNH L
//