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Protein

Calponin

Gene

CNN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-bindingUniRule annotation, Calmodulin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
CalponinUniRule annotation
Gene namesi
Name:CNN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:2156. CNN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064666.

PTM / Processingi

Proteomic databases

MaxQBiB4DDF4.
PeptideAtlasiB4DDF4.
PRIDEiB4DDF4.

Expressioni

Gene expression databases

BgeeiENSG00000064666.
ExpressionAtlasiB4DDF4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263097.

Structurei

3D structure databases

ProteinModelPortaliB4DDF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 117Actin-bindingInterPro annotationAdd BLAST90

Sequence similaritiesi

Belongs to the calponin family.UniRule annotation
Contains 1 CH (calponin-homology) domain.UniRule annotation
Contains 3 calponin-like repeats.UniRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOVERGENiHBG005186.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR029974. CNN2.
IPR003096. SM22_calponin.
[Graphical view]
PANTHERiPTHR18959:SF47. PTHR18959:SF47. 1 hit.
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DDF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF
60 70 80 90 100
QKGLKDGTIL CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM
110 120 130 140 150
NPVDLFEAND LFESGNMTQA KTKGLQSGVD IGVKYSEKQE RNFDDATMKA
160 170 180 190 200
GQCVIGLQMG TNKCASQSGM TAYGTRRHLY DPKNHILPPM DHSTISLQMG
210 220 230 240 250
TNKCASQVGM TAPGTRRHIY DTKLGTDKCD NSSMSLQMGY TQGANQSGQV
260 270 280 290
FGLGRQIYDP KYCPQGTVAD GAPSGTGDCP DPGEVPEYPP YYQEEAGY
Length:298
Mass (Da):32,617
Last modified:September 23, 2008 - v1
Checksum:i0EFA23584C630B2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. No translation available.
AC011558 Genomic DNA. No translation available.
AK293171 mRNA. Translation: BAG56715.1.
RefSeqiNP_001290428.1. NM_001303499.1.
UniGeneiHs.651512.

Genome annotation databases

EnsembliENST00000565096; ENSP00000457968; ENSG00000064666.
GeneIDi1265.
UCSCiuc010xgb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. No translation available.
AC011558 Genomic DNA. No translation available.
AK293171 mRNA. Translation: BAG56715.1.
RefSeqiNP_001290428.1. NM_001303499.1.
UniGeneiHs.651512.

3D structure databases

ProteinModelPortaliB4DDF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263097.

Proteomic databases

MaxQBiB4DDF4.
PeptideAtlasiB4DDF4.
PRIDEiB4DDF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000565096; ENSP00000457968; ENSG00000064666.
GeneIDi1265.
UCSCiuc010xgb.3. human.

Organism-specific databases

CTDi1265.
HGNCiHGNC:2156. CNN2.
OpenTargetsiENSG00000064666.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOVERGENiHBG005186.

Miscellaneous databases

ChiTaRSiCNN2. human.
GenomeRNAii1265.

Gene expression databases

BgeeiENSG00000064666.
ExpressionAtlasiB4DDF4. baseline and differential.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR029974. CNN2.
IPR003096. SM22_calponin.
[Graphical view]
PANTHERiPTHR18959:SF47. PTHR18959:SF47. 1 hit.
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DDF4_HUMAN
AccessioniPrimary (citable) accession number: B4DDF4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.